Vitamin D receptor regulates TNF-mediated arthritis

Objective Reduced vitamin D intake has been linked to increased susceptibility to develop rheumatoid arthritis (RA) and vitamin D deficiency is associated with increased disease activity in RA patients. The pathophysiological role of vitamin D in joint inflammation is, however, unclear. Methods To d...

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Veröffentlicht in:	Annals of the rheumatic diseases 2011-06, Vol.70 (6), p.1122-1129
Hauptverfasser:	Zwerina, Karin, Baum, Wolfgang, Axmann, Roland, Heiland, Gisela Ruiz, Distler, Jörg H, Smolen, Josef, Hayer, Silvia, Zwerina, Jochen, Schett, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoimmune diseases Biological and medical sciences Bone Density - physiology Bone marrow Bone Resorption - metabolism Bone Resorption - physiopathology Cartilage, Articular - metabolism Cells, Cultured Cytokines Cytokines - biosynthesis Disease Diseases of the osteoarticular system Genotype & phenotype Granulocytes Immune system Inflammation Macrophages - pathology Macrophages - physiology Medical sciences Mice Mice, Knockout Mice, Transgenic Miscellaneous. Osteoarticular involvement in other diseases Mortality Neutrophils Osteoclasts - physiology Pathogenesis Proteoglycans - metabolism Receptors, Calcitriol - deficiency Receptors, Calcitriol - physiology Signal Transduction - physiology Studies Synovitis - metabolism Synovitis - pathology Transgenic animals Tumor Necrosis Factor-alpha - physiology Tumor necrosis factor-TNF Vitamin D Vitamin deficiency
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