Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy

Vasectomy is a well accepted global contraceptive approach frequently associated with epididymal granuloma and sperm autoantibody formation. To understand the long-term sequelae of vasectomy, we investigated the early immune response in vasectomized mice. Vasectomy leads to rapid epithelial cell apo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-05, Vol.108 (18), p.7511-7516
Hauptverfasser:	Wheeler, Karen, Tardif, Steve, Rival, Claudia, Luu, Brian, Bui, Elise, del Rio, Roxana, Teuscher, Cory, Sparwasser, Tim, Hardy, Daniel, Tung, Kenneth S.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Apoptosis Autoantibodies Autoantibodies - immunology Autoimmunity Autoimmunity - immunology Biological Sciences Blotting, Western CD25 antigen CD4 antigen CD4-positive T-lymphocytes Cell Proliferation Complications complications (disease) Contraceptives Electrophoresis, Polyacrylamide Gel encephalitis Epididymis Epithelial cells Experimental allergic encephalomyelitis Foxp3 protein Genetics Granuloma Immune response Immune tolerance Immune Tolerance - immunology Immunological tolerance Immunoregulation Inflammation Lymphocytes T Male Membrane Proteins - immunology Mice Mice, Mutant Strains Necrosis Orchitis Rodents Sperm Spermatozoa Spermatozoa - immunology Statistics, Nonparametric T cell receptors T lymphocytes T-Lymphocytes, Regulatory - immunology Testes variance Vasectomy
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