Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages
Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory...
Gespeichert in:
| Veröffentlicht in: | Journal of agricultural and food chemistry 2011-05, Vol.59 (9), p.4544-4552 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4552 |
|---|---|
| container_issue | 9 |
| container_start_page | 4544 |
| container_title | Journal of agricultural and food chemistry |
| container_volume | 59 |
| creator | Fujiwara, Yukio Hayashida, Akinori Tsurushima, Keiichiro Nagai, Ryoji Yoshitomi, Makiko Daiguji, Norika Sakashita, Naomi Takeya, Motohiro Tsukamoto, Sachiko Ikeda, Tsuyoshi |
| description | Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba, the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis. |
| doi_str_mv | 10.1021/jf200193r |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_864965170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>864965170</sourcerecordid><originalsourceid>FETCH-LOGICAL-a368t-e835db2fcd9d3e4788b7474ff3dc3dd486d5bf0e6374c47f233a63861463be683</originalsourceid><addsrcrecordid>eNpt0T9P3DAYBnCrKirH0aFfALwg1CGtHf-9EZ2gPekQQ4GhS_QmtjlHSZzayQCfHld3haWTLfmnx6-eF6EvlHyjpKTfW1cSQlcsfkALKkpSCEr1R7Qg-bHQQtJjdJJSSwjRQpFP6LiknEsl9AI93kc_2TjaIXiT8CaFDiZrsIuhx7_9y_O4mxNu53auAW-Gna_9hG8C9Hhtuy7fYg-TDwP2A76FJoZxB082naIjB12ynw_nEj3cXN-vfxbbux-b9dW2ACb1VFjNhKlL15iVYZYrrWvFFXeOmYYZw7U0onbESqZ4w5UrGQPJtKRcstpKzZbocp87xvBntmmqep-aPBkMNsyp0pKvpKCKZPl1L_OMKUXrqjH6HuJzRUn1t8XqrcVszw6pc91b8yb_1ZbBxQFAaqBzEYbGp3fHKVP53-zO985BqOApZvPwqySU51WsRE57T4ImVW2Y45Dr-s9Ir1cdjuk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>864965170</pqid></control><display><type>article</type><title>Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages</title><source>MEDLINE</source><source>ACS Publications</source><creator>Fujiwara, Yukio ; Hayashida, Akinori ; Tsurushima, Keiichiro ; Nagai, Ryoji ; Yoshitomi, Makiko ; Daiguji, Norika ; Sakashita, Naomi ; Takeya, Motohiro ; Tsukamoto, Sachiko ; Ikeda, Tsuyoshi</creator><creatorcontrib>Fujiwara, Yukio ; Hayashida, Akinori ; Tsurushima, Keiichiro ; Nagai, Ryoji ; Yoshitomi, Makiko ; Daiguji, Norika ; Sakashita, Naomi ; Takeya, Motohiro ; Tsukamoto, Sachiko ; Ikeda, Tsuyoshi</creatorcontrib><description>Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba, the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf200193r</identifier><identifier>PMID: 21446758</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>atherosclerosis ; Atherosclerosis - drug therapy ; Atherosclerosis - prevention & control ; Bioactive Constituents ; Biological and medical sciences ; Cells, Cultured ; Down-Regulation - drug effects ; Foam Cells - cytology ; Foam Cells - drug effects ; foams ; Food industries ; Fruit - chemistry ; Fundamental and applied biological sciences. Psychology ; Humans ; low density lipoprotein ; macrophages ; Macrophages - cytology ; Macrophages - drug effects ; plant extracts ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; triterpenoids ; Ziziphus - chemistry ; Ziziphus jujuba</subject><ispartof>Journal of agricultural and food chemistry, 2011-05, Vol.59 (9), p.4544-4552</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a368t-e835db2fcd9d3e4788b7474ff3dc3dd486d5bf0e6374c47f233a63861463be683</citedby><cites>FETCH-LOGICAL-a368t-e835db2fcd9d3e4788b7474ff3dc3dd486d5bf0e6374c47f233a63861463be683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf200193r$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf200193r$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24137965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21446758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujiwara, Yukio</creatorcontrib><creatorcontrib>Hayashida, Akinori</creatorcontrib><creatorcontrib>Tsurushima, Keiichiro</creatorcontrib><creatorcontrib>Nagai, Ryoji</creatorcontrib><creatorcontrib>Yoshitomi, Makiko</creatorcontrib><creatorcontrib>Daiguji, Norika</creatorcontrib><creatorcontrib>Sakashita, Naomi</creatorcontrib><creatorcontrib>Takeya, Motohiro</creatorcontrib><creatorcontrib>Tsukamoto, Sachiko</creatorcontrib><creatorcontrib>Ikeda, Tsuyoshi</creatorcontrib><title>Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba, the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis.</description><subject>atherosclerosis</subject><subject>Atherosclerosis - drug therapy</subject><subject>Atherosclerosis - prevention & control</subject><subject>Bioactive Constituents</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Down-Regulation - drug effects</subject><subject>Foam Cells - cytology</subject><subject>Foam Cells - drug effects</subject><subject>foams</subject><subject>Food industries</subject><subject>Fruit - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>low density lipoprotein</subject><subject>macrophages</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>plant extracts</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>triterpenoids</subject><subject>Ziziphus - chemistry</subject><subject>Ziziphus jujuba</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0T9P3DAYBnCrKirH0aFfALwg1CGtHf-9EZ2gPekQQ4GhS_QmtjlHSZzayQCfHld3haWTLfmnx6-eF6EvlHyjpKTfW1cSQlcsfkALKkpSCEr1R7Qg-bHQQtJjdJJSSwjRQpFP6LiknEsl9AI93kc_2TjaIXiT8CaFDiZrsIuhx7_9y_O4mxNu53auAW-Gna_9hG8C9Hhtuy7fYg-TDwP2A76FJoZxB082naIjB12ynw_nEj3cXN-vfxbbux-b9dW2ACb1VFjNhKlL15iVYZYrrWvFFXeOmYYZw7U0onbESqZ4w5UrGQPJtKRcstpKzZbocp87xvBntmmqep-aPBkMNsyp0pKvpKCKZPl1L_OMKUXrqjH6HuJzRUn1t8XqrcVszw6pc91b8yb_1ZbBxQFAaqBzEYbGp3fHKVP53-zO985BqOApZvPwqySU51WsRE57T4ImVW2Y45Dr-s9Ir1cdjuk</recordid><startdate>20110511</startdate><enddate>20110511</enddate><creator>Fujiwara, Yukio</creator><creator>Hayashida, Akinori</creator><creator>Tsurushima, Keiichiro</creator><creator>Nagai, Ryoji</creator><creator>Yoshitomi, Makiko</creator><creator>Daiguji, Norika</creator><creator>Sakashita, Naomi</creator><creator>Takeya, Motohiro</creator><creator>Tsukamoto, Sachiko</creator><creator>Ikeda, Tsuyoshi</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110511</creationdate><title>Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages</title><author>Fujiwara, Yukio ; Hayashida, Akinori ; Tsurushima, Keiichiro ; Nagai, Ryoji ; Yoshitomi, Makiko ; Daiguji, Norika ; Sakashita, Naomi ; Takeya, Motohiro ; Tsukamoto, Sachiko ; Ikeda, Tsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a368t-e835db2fcd9d3e4788b7474ff3dc3dd486d5bf0e6374c47f233a63861463be683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>atherosclerosis</topic><topic>Atherosclerosis - drug therapy</topic><topic>Atherosclerosis - prevention & control</topic><topic>Bioactive Constituents</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Down-Regulation - drug effects</topic><topic>Foam Cells - cytology</topic><topic>Foam Cells - drug effects</topic><topic>foams</topic><topic>Food industries</topic><topic>Fruit - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>low density lipoprotein</topic><topic>macrophages</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>plant extracts</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>triterpenoids</topic><topic>Ziziphus - chemistry</topic><topic>Ziziphus jujuba</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujiwara, Yukio</creatorcontrib><creatorcontrib>Hayashida, Akinori</creatorcontrib><creatorcontrib>Tsurushima, Keiichiro</creatorcontrib><creatorcontrib>Nagai, Ryoji</creatorcontrib><creatorcontrib>Yoshitomi, Makiko</creatorcontrib><creatorcontrib>Daiguji, Norika</creatorcontrib><creatorcontrib>Sakashita, Naomi</creatorcontrib><creatorcontrib>Takeya, Motohiro</creatorcontrib><creatorcontrib>Tsukamoto, Sachiko</creatorcontrib><creatorcontrib>Ikeda, Tsuyoshi</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujiwara, Yukio</au><au>Hayashida, Akinori</au><au>Tsurushima, Keiichiro</au><au>Nagai, Ryoji</au><au>Yoshitomi, Makiko</au><au>Daiguji, Norika</au><au>Sakashita, Naomi</au><au>Takeya, Motohiro</au><au>Tsukamoto, Sachiko</au><au>Ikeda, Tsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2011-05-11</date><risdate>2011</risdate><volume>59</volume><issue>9</issue><spage>4544</spage><epage>4552</epage><pages>4544-4552</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba, the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>21446758</pmid><doi>10.1021/jf200193r</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8561 |
| ispartof | Journal of agricultural and food chemistry, 2011-05, Vol.59 (9), p.4544-4552 |
| issn | 0021-8561 1520-5118 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_864965170 |
| source | MEDLINE; ACS Publications |
| subjects | atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - prevention & control Bioactive Constituents Biological and medical sciences Cells, Cultured Down-Regulation - drug effects Foam Cells - cytology Foam Cells - drug effects foams Food industries Fruit - chemistry Fundamental and applied biological sciences. Psychology Humans low density lipoprotein macrophages Macrophages - cytology Macrophages - drug effects plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoids Ziziphus - chemistry Ziziphus jujuba |
| title | Triterpenoids Isolated from Zizyphus jujuba Inhibit Foam Cell Formation in Macrophages |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T10%3A23%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Triterpenoids%20Isolated%20from%20Zizyphus%20jujuba%20Inhibit%20Foam%20Cell%20Formation%20in%20Macrophages&rft.jtitle=Journal%20of%20agricultural%20and%20food%20chemistry&rft.au=Fujiwara,%20Yukio&rft.date=2011-05-11&rft.volume=59&rft.issue=9&rft.spage=4544&rft.epage=4552&rft.pages=4544-4552&rft.issn=0021-8561&rft.eissn=1520-5118&rft.coden=JAFCAU&rft_id=info:doi/10.1021/jf200193r&rft_dat=%3Cproquest_cross%3E864965170%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=864965170&rft_id=info:pmid/21446758&rfr_iscdi=true |