Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency
ObjectiveThe objective was to study the associations between serum selenium concentration and thyroid volume, as well as the association between serum selenium concentration and risk for an enlarged thyroid gland in an area with mild iodine deficiency before and after iodine fortification was introd...
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| Veröffentlicht in: | European journal of endocrinology 2011-04, Vol.164 (4), p.585-590 |
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| container_title | European journal of endocrinology |
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| creator | Rasmussen, Lone Banke Schomburg, Lutz Köhrle, Josef Pedersen, Inge Bülow Hollenbach, Birgit Hög, Antonia Ovesen, Lars Perrild, Hans Laurberg, Peter |
| description | ObjectiveThe objective was to study the associations between serum selenium concentration and thyroid volume, as well as the association between serum selenium concentration and risk for an enlarged thyroid gland in an area with mild iodine deficiency before and after iodine fortification was introduced. Another objective was to examine the association between serum selenium concentration and prevalence of thyroid nodules.DesignCross-sectional study.MethodsWe studied participants of two similar cross-sectional studies carried out before (1997–1998, n=405) and after (2004–2005, n=400) introduction of iodine fortification. Serum selenium concentration and urinary iodine were measured, and the thyroid gland was examined by ultrasonography in the same subjects. Associations between serum selenium concentration and thyroid parameters were examined in multiple linear regression models or logistic regression models.ResultsSerum selenium concentration was found to be significantly, negatively associated with thyroid volume (P=0.006), and a low selenium status significantly increased the risk for thyroid enlargement (P=0.007). Furthermore, low serum selenium status had a tendency to increase the risk for development of multiple nodules (P=0.087).ConclusionsLow serum selenium concentration was associated with a larger thyroid volume and a higher prevalence of thyroid enlargement. |
| doi_str_mv | 10.1530/EJE-10-1026 |
| format | Article |
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Another objective was to examine the association between serum selenium concentration and prevalence of thyroid nodules.DesignCross-sectional study.MethodsWe studied participants of two similar cross-sectional studies carried out before (1997–1998, n=405) and after (2004–2005, n=400) introduction of iodine fortification. Serum selenium concentration and urinary iodine were measured, and the thyroid gland was examined by ultrasonography in the same subjects. Associations between serum selenium concentration and thyroid parameters were examined in multiple linear regression models or logistic regression models.ResultsSerum selenium concentration was found to be significantly, negatively associated with thyroid volume (P=0.006), and a low selenium status significantly increased the risk for thyroid enlargement (P=0.007). Furthermore, low serum selenium status had a tendency to increase the risk for development of multiple nodules (P=0.087).ConclusionsLow serum selenium concentration was associated with a larger thyroid volume and a higher prevalence of thyroid enlargement.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-10-1026</identifier><identifier>PMID: 21242171</identifier><language>eng</language><publisher>Bristol: BioScientifica</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Clinical Study ; Cross-Sectional Studies ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Iodine - deficiency ; Iodine - urine ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Selenium - blood ; Thyroid Diseases - blood ; Thyroid Diseases - diagnostic imaging ; Thyroid Gland - diagnostic imaging ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroid. Thyroid axis (diseases) ; Ultrasonography ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>European journal of endocrinology, 2011-04, Vol.164 (4), p.585-590</ispartof><rights>2011 European Society of Endocrinology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b482t-626a675c07dcc83964dba7db8c0c46c89e12a19ce8a6d9aaef260ff885f7d1be3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24070642$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21242171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasmussen, Lone Banke</creatorcontrib><creatorcontrib>Schomburg, Lutz</creatorcontrib><creatorcontrib>Köhrle, Josef</creatorcontrib><creatorcontrib>Pedersen, Inge Bülow</creatorcontrib><creatorcontrib>Hollenbach, Birgit</creatorcontrib><creatorcontrib>Hög, Antonia</creatorcontrib><creatorcontrib>Ovesen, Lars</creatorcontrib><creatorcontrib>Perrild, Hans</creatorcontrib><creatorcontrib>Laurberg, Peter</creatorcontrib><title>Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>ObjectiveThe objective was to study the associations between serum selenium concentration and thyroid volume, as well as the association between serum selenium concentration and risk for an enlarged thyroid gland in an area with mild iodine deficiency before and after iodine fortification was introduced. Another objective was to examine the association between serum selenium concentration and prevalence of thyroid nodules.DesignCross-sectional study.MethodsWe studied participants of two similar cross-sectional studies carried out before (1997–1998, n=405) and after (2004–2005, n=400) introduction of iodine fortification. Serum selenium concentration and urinary iodine were measured, and the thyroid gland was examined by ultrasonography in the same subjects. Associations between serum selenium concentration and thyroid parameters were examined in multiple linear regression models or logistic regression models.ResultsSerum selenium concentration was found to be significantly, negatively associated with thyroid volume (P=0.006), and a low selenium status significantly increased the risk for thyroid enlargement (P=0.007). Furthermore, low serum selenium status had a tendency to increase the risk for development of multiple nodules (P=0.087).ConclusionsLow serum selenium concentration was associated with a larger thyroid volume and a higher prevalence of thyroid enlargement.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Clinical Study</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Iodine - deficiency</subject><subject>Iodine - urine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Selenium - blood</subject><subject>Thyroid Diseases - blood</subject><subject>Thyroid Diseases - diagnostic imaging</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Ultrasonography</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rh68i65iAe3NUmn0-mjLOMXCx5U8NZUJxUn0p2MSdpl_r1ZZ1bFg1BQdXjqrfCEkMecveBdy15u328bzmoJdYdsuOyHRun2y12yYZrJRirZnpEHOX9jjNeZ3SdnggspeM83BD_ijMGvC80FypovaNkdUvSW_ojzuuAFhWDpss7F72ekIdq1NhfTAsXHQH2oAIWEQK992dHFz5b6aH1AatF54zGYw0Nyz8Gc8dGpn5PPr7efLt82Vx_evLt8ddVMUovSKKFA9Z1hvTVGt4OSdoLeTtowI5XRA3IBfDCoQdkBAJ1QzDmtO9dbPmF7Tp4dc_cpfl8xl3Hx2eA8Q8C45lErWUO7rq3k8yNpUsw5oRv3yS-QDiNn443WsWr9NVetlX5yyl2nBe1v9tZjBZ6eAMgGZpcgGJ__cJL1TElROXHkdv7r7tonHCcf842k4qss-Pv67afWJX5c-of934t_ArDzoSU</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Rasmussen, Lone Banke</creator><creator>Schomburg, Lutz</creator><creator>Köhrle, Josef</creator><creator>Pedersen, Inge Bülow</creator><creator>Hollenbach, Birgit</creator><creator>Hög, Antonia</creator><creator>Ovesen, Lars</creator><creator>Perrild, Hans</creator><creator>Laurberg, Peter</creator><general>BioScientifica</general><general>European Society of Endocrinology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency</title><author>Rasmussen, Lone Banke ; Schomburg, Lutz ; Köhrle, Josef ; Pedersen, Inge Bülow ; Hollenbach, Birgit ; Hög, Antonia ; Ovesen, Lars ; Perrild, Hans ; Laurberg, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b482t-626a675c07dcc83964dba7db8c0c46c89e12a19ce8a6d9aaef260ff885f7d1be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Clinical Study</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Iodine - deficiency</topic><topic>Iodine - urine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Selenium - blood</topic><topic>Thyroid Diseases - blood</topic><topic>Thyroid Diseases - diagnostic imaging</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Ultrasonography</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasmussen, Lone Banke</creatorcontrib><creatorcontrib>Schomburg, Lutz</creatorcontrib><creatorcontrib>Köhrle, Josef</creatorcontrib><creatorcontrib>Pedersen, Inge Bülow</creatorcontrib><creatorcontrib>Hollenbach, Birgit</creatorcontrib><creatorcontrib>Hög, Antonia</creatorcontrib><creatorcontrib>Ovesen, Lars</creatorcontrib><creatorcontrib>Perrild, Hans</creatorcontrib><creatorcontrib>Laurberg, Peter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasmussen, Lone Banke</au><au>Schomburg, Lutz</au><au>Köhrle, Josef</au><au>Pedersen, Inge Bülow</au><au>Hollenbach, Birgit</au><au>Hög, Antonia</au><au>Ovesen, Lars</au><au>Perrild, Hans</au><au>Laurberg, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>164</volume><issue>4</issue><spage>585</spage><epage>590</epage><pages>585-590</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>ObjectiveThe objective was to study the associations between serum selenium concentration and thyroid volume, as well as the association between serum selenium concentration and risk for an enlarged thyroid gland in an area with mild iodine deficiency before and after iodine fortification was introduced. Another objective was to examine the association between serum selenium concentration and prevalence of thyroid nodules.DesignCross-sectional study.MethodsWe studied participants of two similar cross-sectional studies carried out before (1997–1998, n=405) and after (2004–2005, n=400) introduction of iodine fortification. Serum selenium concentration and urinary iodine were measured, and the thyroid gland was examined by ultrasonography in the same subjects. Associations between serum selenium concentration and thyroid parameters were examined in multiple linear regression models or logistic regression models.ResultsSerum selenium concentration was found to be significantly, negatively associated with thyroid volume (P=0.006), and a low selenium status significantly increased the risk for thyroid enlargement (P=0.007). Furthermore, low serum selenium status had a tendency to increase the risk for development of multiple nodules (P=0.087).ConclusionsLow serum selenium concentration was associated with a larger thyroid volume and a higher prevalence of thyroid enlargement.</abstract><cop>Bristol</cop><pub>BioScientifica</pub><pmid>21242171</pmid><doi>10.1530/EJE-10-1026</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of endocrinology, 2011-04, Vol.164 (4), p.585-590 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adolescent Adult Aged Biological and medical sciences Clinical Study Cross-Sectional Studies Endocrinopathies Female Fundamental and applied biological sciences. Psychology Humans Iodine - deficiency Iodine - urine Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Selenium - blood Thyroid Diseases - blood Thyroid Diseases - diagnostic imaging Thyroid Gland - diagnostic imaging Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid. Thyroid axis (diseases) Ultrasonography Vertebrates: endocrinology Young Adult |
| title | Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency |
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