Non-toxic derivatives of LT as potent adjuvants

The heat-labile enterotoxin of Escherichia coli (LT) consists of an enzymatically active A subunit (LTA) and a pentameric B subunit (LTB). LT has been extensively studied as a potent modulator of immune responses but wild-type LT is toxic and therefore unsuitable for clinical use. Approaches pursued...

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Veröffentlicht in:	Vaccine 2011-02, Vol.29 (8), p.1538-1544
Hauptverfasser:	da Hora, Vanusa P, Conceição, Fabricio R, Dellagostin, Odir A, Doolan, Denise L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants Adjuvants, Immunologic - pharmacology Allergy and Immunology Animals Antibodies Applied microbiology Bacterial Toxins - pharmacology Biological and medical sciences E coli enterotoxins Enterotoxins - pharmacology Escherichia coli Escherichia coli - immunology Escherichia coli Proteins - pharmacology FDA approval Fundamental and applied biological sciences. Psychology heat-labile enterotoxin Human papillomavirus Humans Immune response Immunomodulation immunomodulators Influenza Licenses LTB LTK63 Lymphocytes Microbiology Mucosa mutants Mutation Proteins Recombinant Proteins - pharmacology Reviews Streptococcus infections Toxicity Toxins vaccine adjuvants Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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