Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients
Cite this as: K. Reginald, K. Westritschnig, T. Werfel, A. Heratizadeh, N. Novak, M. Focke‐Tejkl, A. M. Hirschl, D. Y. M. Leung, O. Elisyutina, E. Fedenko and R. Valenta, Clinical & Experimental Allergy, 2011 (41) 357–369. Summary Background Atopic dermatitis (AD) is a chronic inflammatory skin...
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| creator | Reginald, K. Westritschnig, K. Werfel, T. Heratizadeh, A. Novak, N. Focke-Tejkl, M. Hirschl, A. M. Leung, D. Y. M. Elisyutina, O. Fedenko, E. Valenta, R. |
| description | Cite this as: K. Reginald, K. Westritschnig, T. Werfel, A. Heratizadeh, N. Novak, M. Focke‐Tejkl, A. M. Hirschl, D. Y. M. Leung, O. Elisyutina, E. Fedenko and R. Valenta, Clinical & Experimental Allergy, 2011 (41) 357–369.
Summary
Background
Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% children and 9% adults world‐wide. AD patients are often sensitized against a broad variety of allergens and more than 90% of them suffer from skin superinfections with Staphylococcus aureus.
Objective
In this study, we searched for the presence of specific IgE antibodies against S. aureus and Escherichia coli antigens in AD patients.
Methods
Sera from AD patients (n=79), patients suffering only from allergic rhinoconjunctivitis (n=41) or allergic asthma (n=37) were tested for IgE reactivity to nitrocellulose‐blotted S. aureus, E. coli and gut bacterial antigens. IgE‐reactive bacterial antigens were affinity purified and identified by mass spectrometry.
Results
More than 30% of AD patients but not patients suffering only from allergic rhinoconjunctivitis and asthma or non‐allergic persons exhibited IgE binding to several protein antigens among them DNA‐binding and ribosomal proteins and flagellin. Patients with severe skin manifestations showed more frequently IgE reactivity to S. aureus compared with AD patients with mild symptoms. Positive immediate and late skin test reactions could be induced in sensitized AD patients with S. aureus extract.
Conclusion and Clinical Relevance
Specific IgE reactivities against a variety of bacterial antigens were observed in a subgroup comprising a third of AD patients and may contribute to allergic inflammation. |
| doi_str_mv | 10.1111/j.1365-2222.2010.03655.x |
| format | Article |
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Summary
Background
Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% children and 9% adults world‐wide. AD patients are often sensitized against a broad variety of allergens and more than 90% of them suffer from skin superinfections with Staphylococcus aureus.
Objective
In this study, we searched for the presence of specific IgE antibodies against S. aureus and Escherichia coli antigens in AD patients.
Methods
Sera from AD patients (n=79), patients suffering only from allergic rhinoconjunctivitis (n=41) or allergic asthma (n=37) were tested for IgE reactivity to nitrocellulose‐blotted S. aureus, E. coli and gut bacterial antigens. IgE‐reactive bacterial antigens were affinity purified and identified by mass spectrometry.
Results
More than 30% of AD patients but not patients suffering only from allergic rhinoconjunctivitis and asthma or non‐allergic persons exhibited IgE binding to several protein antigens among them DNA‐binding and ribosomal proteins and flagellin. Patients with severe skin manifestations showed more frequently IgE reactivity to S. aureus compared with AD patients with mild symptoms. Positive immediate and late skin test reactions could be induced in sensitized AD patients with S. aureus extract.
Conclusion and Clinical Relevance
Specific IgE reactivities against a variety of bacterial antigens were observed in a subgroup comprising a third of AD patients and may contribute to allergic inflammation.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2010.03655.x</identifier><identifier>PMID: 21155910</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Allergens ; Allergies ; Alzheimer's disease ; Antibodies, Bacterial - blood ; Antibodies, Bacterial - immunology ; Antigens, Bacterial - immunology ; Asthma ; Atopic dermatitis ; bacterial allergen ; bacterial antigens ; Children ; Dermatitis ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - immunology ; Digestive tract ; Escherichia coli ; Escherichia coli - immunology ; Female ; Flagellin ; Humans ; Hypersensitivity ; Immunoblotting ; Immunoglobulin E ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Inflammation ; Inflammatory diseases ; Male ; Mass Spectrometry ; Mass spectroscopy ; Middle Aged ; rhinoconjunctivitis ; Ribosomal proteins ; Skin diseases ; Skin Tests ; Staphylococcus aureus ; Staphylococcus aureus - immunology ; Superinfection ; Young Adult</subject><ispartof>Clinical and experimental allergy, 2011-03, Vol.41 (3), p.357-369</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2010 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5335-32caf1e027fdbb1ff3bb51501c849484c3e01d23f018bb842e6c7d9adfd948613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.2010.03655.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.2010.03655.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21155910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reginald, K.</creatorcontrib><creatorcontrib>Westritschnig, K.</creatorcontrib><creatorcontrib>Werfel, T.</creatorcontrib><creatorcontrib>Heratizadeh, A.</creatorcontrib><creatorcontrib>Novak, N.</creatorcontrib><creatorcontrib>Focke-Tejkl, M.</creatorcontrib><creatorcontrib>Hirschl, A. M.</creatorcontrib><creatorcontrib>Leung, D. Y. M.</creatorcontrib><creatorcontrib>Elisyutina, O.</creatorcontrib><creatorcontrib>Fedenko, E.</creatorcontrib><creatorcontrib>Valenta, R.</creatorcontrib><title>Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Cite this as: K. Reginald, K. Westritschnig, T. Werfel, A. Heratizadeh, N. Novak, M. Focke‐Tejkl, A. M. Hirschl, D. Y. M. Leung, O. Elisyutina, E. Fedenko and R. Valenta, Clinical & Experimental Allergy, 2011 (41) 357–369.
Summary
Background
Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% children and 9% adults world‐wide. AD patients are often sensitized against a broad variety of allergens and more than 90% of them suffer from skin superinfections with Staphylococcus aureus.
Objective
In this study, we searched for the presence of specific IgE antibodies against S. aureus and Escherichia coli antigens in AD patients.
Methods
Sera from AD patients (n=79), patients suffering only from allergic rhinoconjunctivitis (n=41) or allergic asthma (n=37) were tested for IgE reactivity to nitrocellulose‐blotted S. aureus, E. coli and gut bacterial antigens. IgE‐reactive bacterial antigens were affinity purified and identified by mass spectrometry.
Results
More than 30% of AD patients but not patients suffering only from allergic rhinoconjunctivitis and asthma or non‐allergic persons exhibited IgE binding to several protein antigens among them DNA‐binding and ribosomal proteins and flagellin. Patients with severe skin manifestations showed more frequently IgE reactivity to S. aureus compared with AD patients with mild symptoms. Positive immediate and late skin test reactions could be induced in sensitized AD patients with S. aureus extract.
Conclusion and Clinical Relevance
Specific IgE reactivities against a variety of bacterial antigens were observed in a subgroup comprising a third of AD patients and may contribute to allergic inflammation.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allergens</subject><subject>Allergies</subject><subject>Alzheimer's disease</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antigens, Bacterial - immunology</subject><subject>Asthma</subject><subject>Atopic dermatitis</subject><subject>bacterial allergen</subject><subject>bacterial antigens</subject><subject>Children</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Digestive tract</subject><subject>Escherichia coli</subject><subject>Escherichia coli - immunology</subject><subject>Female</subject><subject>Flagellin</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Immunoblotting</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Mass spectroscopy</subject><subject>Middle Aged</subject><subject>rhinoconjunctivitis</subject><subject>Ribosomal proteins</subject><subject>Skin diseases</subject><subject>Skin Tests</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - immunology</subject><subject>Superinfection</subject><subject>Young Adult</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu2zAQRYmiQewm-YWCQBddyeGQoh6LLgLDSVPkgQAJkh1BSpRBVw9XpFr77zuyHS-66WyGwzl3QM4lhAKbAcblagYikRHHmHGGtwxLOdt8INNj4yOZslzGUZrl8YR88n7FGBMyz07JhANImQObkrfbphnabll3ZqhdSxdUt8GZrtzS3uoiuN8ubGnoqMHC9k7XO2BpW08R16Fbu4KWtm90cMF5usZs2-DPyUmla28vDvmMvFwvnuffo7vHm9v51V1USCFkJHihK7CMp1VpDFSVMEaCZFBkcR5ncSEsg5KLikFmTBZzmxRpmeuyKrGdgDgjX_dz1333a7A-qMb5wta1bm03eJUlcZ4ACP5_ElfCkkQyJL_8Q666oW_xGwokz_F1IhVIfT5Qg2lsqda9a3S_Ve_LReDbHvjjars99oGp0US1UqNXavRKjSaqnYlqo-aLq_GE-mivdz7YzVGv-58qSUUq1evDjfqBy7rPngDVfwH1l54a</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Reginald, K.</creator><creator>Westritschnig, K.</creator><creator>Werfel, T.</creator><creator>Heratizadeh, A.</creator><creator>Novak, N.</creator><creator>Focke-Tejkl, M.</creator><creator>Hirschl, A. M.</creator><creator>Leung, D. Y. M.</creator><creator>Elisyutina, O.</creator><creator>Fedenko, E.</creator><creator>Valenta, R.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201103</creationdate><title>Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients</title><author>Reginald, K. ; Westritschnig, K. ; Werfel, T. ; Heratizadeh, A. ; Novak, N. ; Focke-Tejkl, M. ; Hirschl, A. M. ; Leung, D. Y. M. ; Elisyutina, O. ; Fedenko, E. ; Valenta, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5335-32caf1e027fdbb1ff3bb51501c849484c3e01d23f018bb842e6c7d9adfd948613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allergens</topic><topic>Allergies</topic><topic>Alzheimer's disease</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Antigens, Bacterial - immunology</topic><topic>Asthma</topic><topic>Atopic dermatitis</topic><topic>bacterial allergen</topic><topic>bacterial antigens</topic><topic>Children</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - blood</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Digestive tract</topic><topic>Escherichia coli</topic><topic>Escherichia coli - immunology</topic><topic>Female</topic><topic>Flagellin</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Immunoblotting</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Mass spectroscopy</topic><topic>Middle Aged</topic><topic>rhinoconjunctivitis</topic><topic>Ribosomal proteins</topic><topic>Skin diseases</topic><topic>Skin Tests</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - immunology</topic><topic>Superinfection</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reginald, K.</creatorcontrib><creatorcontrib>Westritschnig, K.</creatorcontrib><creatorcontrib>Werfel, T.</creatorcontrib><creatorcontrib>Heratizadeh, A.</creatorcontrib><creatorcontrib>Novak, N.</creatorcontrib><creatorcontrib>Focke-Tejkl, M.</creatorcontrib><creatorcontrib>Hirschl, A. M.</creatorcontrib><creatorcontrib>Leung, D. Y. M.</creatorcontrib><creatorcontrib>Elisyutina, O.</creatorcontrib><creatorcontrib>Fedenko, E.</creatorcontrib><creatorcontrib>Valenta, R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reginald, K.</au><au>Westritschnig, K.</au><au>Werfel, T.</au><au>Heratizadeh, A.</au><au>Novak, N.</au><au>Focke-Tejkl, M.</au><au>Hirschl, A. M.</au><au>Leung, D. Y. M.</au><au>Elisyutina, O.</au><au>Fedenko, E.</au><au>Valenta, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2011-03</date><risdate>2011</risdate><volume>41</volume><issue>3</issue><spage>357</spage><epage>369</epage><pages>357-369</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Cite this as: K. Reginald, K. Westritschnig, T. Werfel, A. Heratizadeh, N. Novak, M. Focke‐Tejkl, A. M. Hirschl, D. Y. M. Leung, O. Elisyutina, E. Fedenko and R. Valenta, Clinical & Experimental Allergy, 2011 (41) 357–369.
Summary
Background
Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting up to 20% children and 9% adults world‐wide. AD patients are often sensitized against a broad variety of allergens and more than 90% of them suffer from skin superinfections with Staphylococcus aureus.
Objective
In this study, we searched for the presence of specific IgE antibodies against S. aureus and Escherichia coli antigens in AD patients.
Methods
Sera from AD patients (n=79), patients suffering only from allergic rhinoconjunctivitis (n=41) or allergic asthma (n=37) were tested for IgE reactivity to nitrocellulose‐blotted S. aureus, E. coli and gut bacterial antigens. IgE‐reactive bacterial antigens were affinity purified and identified by mass spectrometry.
Results
More than 30% of AD patients but not patients suffering only from allergic rhinoconjunctivitis and asthma or non‐allergic persons exhibited IgE binding to several protein antigens among them DNA‐binding and ribosomal proteins and flagellin. Patients with severe skin manifestations showed more frequently IgE reactivity to S. aureus compared with AD patients with mild symptoms. Positive immediate and late skin test reactions could be induced in sensitized AD patients with S. aureus extract.
Conclusion and Clinical Relevance
Specific IgE reactivities against a variety of bacterial antigens were observed in a subgroup comprising a third of AD patients and may contribute to allergic inflammation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21155910</pmid><doi>10.1111/j.1365-2222.2010.03655.x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Allergens Allergies Alzheimer's disease Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antigens, Bacterial - immunology Asthma Atopic dermatitis bacterial allergen bacterial antigens Children Dermatitis Dermatitis, Atopic - blood Dermatitis, Atopic - immunology Digestive tract Escherichia coli Escherichia coli - immunology Female Flagellin Humans Hypersensitivity Immunoblotting Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Inflammation Inflammatory diseases Male Mass Spectrometry Mass spectroscopy Middle Aged rhinoconjunctivitis Ribosomal proteins Skin diseases Skin Tests Staphylococcus aureus Staphylococcus aureus - immunology Superinfection Young Adult |
| title | Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients |
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