Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C

Gastric cancer is the fourth most common cancer and the second leading cause of cancer mortality worldwide but the underlying molecular mechanism is not entirely clear. The objective of this study was to explore the role of let-7a microRNA (miRNA) in gastric tumorigenesis and the possible correlatio...

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Veröffentlicht in:	Carcinogenesis (New York) 2011-05, Vol.32 (5), p.713-722
Hauptverfasser:	QIAOYUAN YANG, ZHIGANG JIE, HONG CAO, GREENLEE, Anne R, CHENGFENG YANG, FEI ZOU, YIGUO JIANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Blotting, Western Carcinogenesis, carcinogens and anticarcinogens Cell Differentiation Cell Proliferation Cell Transformation, Neoplastic - pathology Chemical agents Female G1 Phase Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Luciferases - metabolism Lymphatic Metastasis Male Medical sciences Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Neoplasm Invasiveness rab GTP-Binding Proteins - antagonists & inhibitors rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Xenograft Model Antitumor Assays
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