Intravenous immunoglobulins exposed to heme (heme IVIG) are more efficient than IVIG in attenuating autoimmune diabetes

Abstract Intravenous immunoglobulins (IVIG) are known to have a therapeutic effect in some autoimmune diseases. We examined the effect of IVIG and heme-exposed IVIG on the development of immune mediated diabetes induced in C57BL/6 mice by multiple low doses of streptozotocin. IVIG were used in a dos...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2011-02, Vol.138 (2), p.162-171
Hauptverfasser:	Pavlovic, Sladjana, Zdravkovic, Nemanja, Dimitrov, Jordan D, Djukic, Aleksandar, Arsenijevic, Nebojsa, Vassilev, Tchavdar L, Lukic, Miodrag L
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Autoimmunity Biological and medical sciences Cyclophosphamide - immunology Cytokines - blood Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - prevention & control Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - prevention & control Diabetes. Impaired glucose tolerance Down-Regulation Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Fundamental immunology Glycated Hemoglobin A Glycosuria - immunology Glycosuria - prevention & control Heme - immunology Humans Hyperglycemia - immunology Hyperglycemia - prevention & control Immunoglobulins, Intravenous - immunology Immunoglobulins, Intravenous - therapeutic use IVIG Lymph Nodes - immunology Male Medical sciences Mice Mice, Inbred C57BL T-Lymphocytes, Regulatory - immunology T1D Treg cells
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