Reduced hippocampal glutamate in Alzheimer disease

Abstract Altered neurometabolic profiles have been detected in Alzheimer disease (AD) using1 H magnetic resonance spectroscopy (MRS), but no definitive biomarker of mild cognitive impairment (MCI) or AD has been established. This study used MRS to compare hippocampal metabolite levels between normal...

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Veröffentlicht in:	Neurobiology of aging 2011-05, Vol.32 (5), p.802-810
Hauptverfasser:	Rupsingh, R, Borrie, M, Smith, M, Wells, J.L, Bartha, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer disease Alzheimer Disease - diagnosis Alzheimer Disease - metabolism Biological and medical sciences Biomarkers - analysis Choline - metabolism Creatine - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Development. Senescence. Regeneration. Transplantation Female Fundamental and applied biological sciences. Psychology Glutamate Glutamic Acid - analysis Glutamic Acid - deficiency Hippocampus Hippocampus - chemistry Hippocampus - metabolism Humans Inositol - metabolism Internal Medicine Magnetic Resonance Spectroscopy - methods Male MCI (mild cognitive impairment) Medical sciences MRS Neurology Spectroscopy Vertebrates: nervous system and sense organs
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