Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells

Ursodeoxycholic acid (UDCA) is known as a suppressor of cholestatic liver diseases and colorectal cancer development. Here, we demonstrate that UDCA induces apoptosis without necrotic features in SNU601, SNU638, SNU1 and SNU216 human gastric cancer cells, implying its possible use as an effective ch...

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Veröffentlicht in:	Carcinogenesis (New York) 2011-05, Vol.32 (5), p.723-731
Hauptverfasser:	LIM, Sung-Chul, DUONG, Hong-Quan, JEONG EUN CHOI, LEE, Tae-Bum, KANG, Ju-Hee, SEUNG HYUN OH, SONG IY HAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Blotting, Western Carcinogenesis, carcinogens and anticarcinogens Cell Proliferation Cholagogues and Choleretics - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Membrane Microdomains Mice Mice, Inbred BALB C Necrosis Protein Kinase C-delta - genetics Protein Kinase C-delta - metabolism Reactive Oxygen Species - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - antagonists & inhibitors Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Cells, Cultured Tumors Ursodeoxycholic Acid - pharmacology
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