Matrix stiffness regulation of integrin‐mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells

Mesenchymal stem cells (MSCs) cultured on extracellular matrices with different stiffness have been shown to possess diverse lineage commitment owing to the extracellular mechanical stimuli sensed by the cells. The aim of this study was to further delineate how matrix stiffness affects intracellular...

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Veröffentlicht in:	Journal of bone and mineral research 2011-04, Vol.26 (4), p.730-738
Hauptverfasser:	Shih, Yu‐Ru V, Tseng, Kuo‐Fung, Lai, Hsiu‐Yu, Lin, Chi‐Hung, Lee, Oscar K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemical synthesis Acrylic Resins - chemistry beta Catenin - metabolism Biological and medical sciences Biomechanical Phenomena Calcification, Physiologic - drug effects Calcification, Physiologic - physiology Cell Differentiation - drug effects Cell Differentiation - physiology Collagen Type I - chemistry Collagen Type I - genetics Core Binding Factor Alpha 1 Subunit - genetics Elasticity - physiology Extracellular Matrix - physiology Focal Adhesion Kinase 1 - antagonists & inhibitors Focal Adhesion Kinase 1 - metabolism Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Gene Expression - genetics Humans integrin Integrin alpha2 - genetics Integrin alpha2 - metabolism matrix stiffness mechanotransduction Mechanotransduction, Cellular - physiology mesenchymal stem cell Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism Myosin-Light-Chain Phosphatase - metabolism Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteocalcin - genetics Osteogenesis - physiology osteogenic differentiation Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism RNA, Small Interfering - genetics Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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