AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus

Abstract The cell wall integrity (CWI) pathway, best characterized in S. cerevisiae , is strikingly conserved in Aspergillus species. We analyzed the importance of AfMkk2, a CWI signaling kinase, for virulence and antifungal therapy in the human pathogen A. fumigatus . A mutant lacking AfMkk2 is les...

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Veröffentlicht in:	International journal of medical microbiology 2010-11, Vol.300 (7), p.496-502
Hauptverfasser:	Dirr, Franziska, Echtenacher, Bernd, Heesemann, Jürgen, Hoffmann, Petra, Ebel, Frank, Wagener, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antifungal Agents - pharmacology Aspergillosis - microbiology Aspergillosis - mortality Aspergillus fumigatus Aspergillus fumigatus - drug effects Aspergillus fumigatus - enzymology Aspergillus fumigatus - growth & development Aspergillus fumigatus - pathogenicity Cell Adhesion Cell Wall - physiology Cell wall integrity CWI Disease Models, Animal Glass Humans Hydrogen-Ion Concentration Infectious Disease Medical Education Mice Mitogen-Activated Protein Kinase Kinases - deficiency Mitogen-Activated Protein Kinase Kinases - metabolism Mkk1 Mkk2 MpkA Plastics Pyrimidines - pharmacology Signal Transduction Survival Analysis Temperature Triazoles - pharmacology Virulence Virulence Factors - deficiency Virulence Factors - metabolism Voriconazole
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