The dual role of the extracellular matrix in synaptic plasticity and homeostasis

Key Points Several extracellular matrix (ECM) components, such as Reelin, integrin ligands, tenascin C and hyaluronic acid, regulate induction of synaptic plasticity through their modulatory effects on NMDA ( N -methyl- D -aspartate) receptors and L-type voltage-dependent Ca 2+ channels, which are t...

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Veröffentlicht in:	Nature reviews. Neuroscience 2010-11, Vol.11 (11), p.735-746
Hauptverfasser:	Dityatev, Alexander, Schachner, Melitta, Sonderegger, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1595 631/378/2591 631/443/319/1557 631/80/84/750 Animal Genetics and Genomics Animals Apolipoproteins Behavioral Sciences Biological and medical sciences Biological Techniques Biomedical and Life Sciences Biomedicine Calcium Channels - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Epidermal growth factor Extracellular matrix Extracellular Matrix - physiology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Homeostasis Homeostasis - physiology Humans Hyaluronic acid Kinases Lipoproteins Low density lipoprotein receptors Models, Biological Neurobiology Neuronal Plasticity - physiology Neuroplasticity Neurosciences Physiological aspects Proteins Receptors, N-Methyl-D-Aspartate - physiology review-article Signal Transduction - physiology Synapses - metabolism Vertebrates: nervous system and sense organs
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