Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells

Human bone marrow stromal cells (hMSCs) were stably transduced by a retroviral vector containing the gene for the catalytic subunit of human telomerase (hTERT). Transduced cells (hMSC-TERTs) had telomerase activity, and the mean telomere length was increased as compared with that of control cells. T...

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Veröffentlicht in:	Nature biotechnology 2002-06, Vol.20 (6), p.592-596
Hauptverfasser:	Simonsen, Janne L., Rosada, Cecilia, Serakinci, Nedime, Justesen, Jeannette, Stenderup, Karin, Rattan, Suresh I.S., Jensen, Thomas G., Kassem, Moustapha
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Bone marrow Bone Remodeling - genetics Bone Remodeling - physiology Cell Cycle - genetics Cell Cycle - physiology Cell Differentiation - genetics DNA-Binding Proteins Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Regulation, Developmental - physiology Gene therapy Health. Pharmaceutical industry Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Humans Industrial applications and implications. Economical aspects Karyotypes Life Sciences Medical sciences Mice Osteogenesis - genetics Osteogenesis - physiology Reference Values Sequence Analysis, DNA Stromal Cells - physiology Stromal Cells - transplantation Telomerase - genetics Telomere - genetics Tissue Engineering - methods Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Heterologous
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