Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion

Toll-like receptors (TLRs) are critical mediators of the immune response to pathogens. The influence of human TLR6 polymorphisms on susceptibility to infection is only partially understood. Most microbes contain lipopeptides recognized by TLR2/1 or TLR2/6 heterodimers. Our aim was to determine wheth...

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Veröffentlicht in:	Genes and immunity 2010-10, Vol.11 (7), p.561-572
Hauptverfasser:	Shey, M S, Randhawa, A K, Bowmaker, M, Smith, E, Scriba, T J, de Kock, M, Mahomed, H, Hussey, G, Hawn, T R, Hanekom, W A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/457/649 631/250/127/1213 631/250/255/1856 631/250/262/2106/2108 Adult Alleles Bacillus Calmette-Guerin vaccine BCG Biomedical and Life Sciences Biomedicine Blood Cancer Research Cytokines Cytokines - genetics Gene Expression Gene polymorphism Genetic aspects Genetic diversity Health aspects HEK293 Cells Human Genetics Humans Immune response Immunologic Factors - genetics Immunology Infection Innate immunity Interleukin 6 Interleukin-6 - metabolism Lipopeptides Lipopeptides - metabolism Mycobacterium Mycobacterium bovis - genetics Mycobacterium bovis - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - metabolism NF- Kappa B protein NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein original-article Pathogens Physiological aspects Polymorphism, Single Nucleotide Signal Transduction - genetics Signal Transduction - immunology Single nucleotide polymorphisms Single-nucleotide polymorphism TLR2 protein Toll-Like Receptor 6 - genetics Toll-like receptors Toll-Like Receptors - metabolism Transcription factors Tuberculosis
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