Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX

Crossover between the human sex chromosomes during male meiosis is restricted to the terminal pseudoautosomal pairing regions. An obligatory exchange occurs in PAR1, an Xp/Yp pseudoautosomal region of 2.6 Mb, which creates a male-specific recombination 'hot domain' with a recombination rat...

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Veröffentlicht in:	Nature genetics 2002-07, Vol.31 (3), p.272-275
Hauptverfasser:	May, Celia A, Shone, Angela C, Kalaydjieva, Luba, Sajantila, Antti, Jeffreys, Alec J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chromosomes Crossing over (Genetics) Crossing Over, Genetic Deoxyribonucleic acid Diploidy DNA Fundamental and applied biological sciences. Psychology Gene Function Genes. Genome Genetic Variation Genotype Haplotypes Heterozygote Homeodomain Proteins - genetics Human Genetics Humans Identification and classification Islands letter Linkage (Genetics) Linkage Disequilibrium - genetics Male Meiosis Molecular and cellular biology Molecular genetics Mutation Physiological aspects Polymorphism, Single Nucleotide Pseudogenes Recombinant Proteins - metabolism Recombination, Genetic Short Stature Homeobox Protein Spermatozoa - metabolism Transcription, Genetic X Chromosome - genetics Y Chromosome - genetics
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