catalytic carbohydrate contributes to bacterial antibiotic resistance
Penicillins are widespread in nature and lethal to growing bacteria. Because of the severe threat posed by these antibiotics, bacteria have evolved a wide variety of strategies for combating them. Here, we describe one unusual strategy that involves the activity of a catalytic carbohydrate. We show...
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| Veröffentlicht in: | Extremophiles : life under extreme conditions 2007, Vol.11 (1), p.133-143 |
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| container_title | Extremophiles : life under extreme conditions |
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| creator | de Figueiredo, Paul Terra, Becky Anand, Jasbir Kaur Hikita, Toshiyuki Sadilek, Martin Monks, Dave E Lenskiy, Anastasiya Hakomori, Senitiroh Nester, Eugene W |
| description | Penicillins are widespread in nature and lethal to growing bacteria. Because of the severe threat posed by these antibiotics, bacteria have evolved a wide variety of strategies for combating them. Here, we describe one unusual strategy that involves the activity of a catalytic carbohydrate. We show that the cyclic oligosaccharide, β-cyclodextrin (βCD), can hydrolyze, and thereby inactivate, penicillin in vivo. Moreover, we demonstrate that this catalytic activity contributes to the antibiotic resistance of a bacterium that synthesizes this oligosaccharide in the laboratory. Taken together, these data not only expand our understanding of the biochemistry of penicillin resistance, but also provide the first demonstration of natural carbohydrate-mediated catalysis in a living system. |
| doi_str_mv | 10.1007/s00792-006-0024-3 |
| format | Article |
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Because of the severe threat posed by these antibiotics, bacteria have evolved a wide variety of strategies for combating them. Here, we describe one unusual strategy that involves the activity of a catalytic carbohydrate. We show that the cyclic oligosaccharide, β-cyclodextrin (βCD), can hydrolyze, and thereby inactivate, penicillin in vivo. Moreover, we demonstrate that this catalytic activity contributes to the antibiotic resistance of a bacterium that synthesizes this oligosaccharide in the laboratory. Taken together, these data not only expand our understanding of the biochemistry of penicillin resistance, but also provide the first demonstration of natural carbohydrate-mediated catalysis in a living system.</description><identifier>ISSN: 1431-0651</identifier><identifier>EISSN: 1433-4909</identifier><identifier>DOI: 10.1007/s00792-006-0024-3</identifier><identifier>PMID: 17048043</identifier><language>eng</language><publisher>Heidelberg: Tokyo : Springer-Verlag</publisher><subject>Alkaliphile ; Ampicillin - metabolism ; Ampicillin - pharmacology ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Bacillus subtilis - drug effects ; Bacillus subtilis - growth & development ; Bacillus subtilis - metabolism ; Bacteria ; Bacteriology ; beta-Cyclodextrins - metabolism ; beta-Lactamases - metabolism ; Biological and medical sciences ; Carbohydrates ; Catalysis ; catalytic activity ; Cyclodextrin ; Escherichia coli - drug effects ; Escherichia coli - growth & development ; Escherichia coli - metabolism ; Fundamental and applied biological sciences. Psychology ; Hydrolysis ; Microbial Sensitivity Tests ; Microbiology ; Miscellaneous ; Penicillin ; Penicillin Resistance ; Resistance ; Space life sciences ; Starch - metabolism ; β-lactamase</subject><ispartof>Extremophiles : life under extreme conditions, 2007, Vol.11 (1), p.133-143</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-eddf8acb80a91adde3911eabdb0700e3aa10bdc5a90592e5c88d4fde14ecfa63</citedby><cites>FETCH-LOGICAL-c443t-eddf8acb80a91adde3911eabdb0700e3aa10bdc5a90592e5c88d4fde14ecfa63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18599366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17048043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Figueiredo, Paul</creatorcontrib><creatorcontrib>Terra, Becky</creatorcontrib><creatorcontrib>Anand, Jasbir Kaur</creatorcontrib><creatorcontrib>Hikita, Toshiyuki</creatorcontrib><creatorcontrib>Sadilek, Martin</creatorcontrib><creatorcontrib>Monks, Dave E</creatorcontrib><creatorcontrib>Lenskiy, Anastasiya</creatorcontrib><creatorcontrib>Hakomori, Senitiroh</creatorcontrib><creatorcontrib>Nester, Eugene W</creatorcontrib><title>catalytic carbohydrate contributes to bacterial antibiotic resistance</title><title>Extremophiles : life under extreme conditions</title><addtitle>Extremophiles</addtitle><description>Penicillins are widespread in nature and lethal to growing bacteria. Because of the severe threat posed by these antibiotics, bacteria have evolved a wide variety of strategies for combating them. Here, we describe one unusual strategy that involves the activity of a catalytic carbohydrate. We show that the cyclic oligosaccharide, β-cyclodextrin (βCD), can hydrolyze, and thereby inactivate, penicillin in vivo. Moreover, we demonstrate that this catalytic activity contributes to the antibiotic resistance of a bacterium that synthesizes this oligosaccharide in the laboratory. Taken together, these data not only expand our understanding of the biochemistry of penicillin resistance, but also provide the first demonstration of natural carbohydrate-mediated catalysis in a living system.</description><subject>Alkaliphile</subject><subject>Ampicillin - metabolism</subject><subject>Ampicillin - pharmacology</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Bacillus subtilis - drug effects</subject><subject>Bacillus subtilis - growth & development</subject><subject>Bacillus subtilis - metabolism</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>beta-Cyclodextrins - metabolism</subject><subject>beta-Lactamases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates</subject><subject>Catalysis</subject><subject>catalytic activity</subject><subject>Cyclodextrin</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - growth & development</subject><subject>Escherichia coli - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrolysis</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Penicillin</subject><subject>Penicillin Resistance</subject><subject>Resistance</subject><subject>Space life sciences</subject><subject>Starch - metabolism</subject><subject>β-lactamase</subject><issn>1431-0651</issn><issn>1433-4909</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0UuLFDEQB_AgiruufgAv2gjqqbWq8-jkKMv6gAUPrudQebRm6elek_Rhvr0ZZ2DBgx7ygPyqIPVn7DnCOwQY35e2maEHUG0NoucP2DkKznthwDz8c8celMQz9qSUWwCU7eExO8MRhAbBz9mVp0rzvibfecpu_bkPmWrs_LrUnNxWY-nq2jnyNeZEc0dLTS6th4IcSyqVFh-fskcTzSU-O50X7Obj1c3l5_7666cvlx-uey8Er30MYdLknQYySCFEbhAjueBgBIicCMEFL8mANEOUXusgphBRRD-R4hfs7bHtXV5_bbFUu0vFx3mmJa5bsVoJIxFxaPLNP6XSAg0H-V-IRqECDg2--gverlte2m_tKA2XUqBuCI_I57WUHCd7l9OO8t4i2ENk9hiZbZHZQ2SWt5oXp8ab28VwX3HKqIHXJ0DF0zzlNvFU7p2WxnB1mM7Lo5totfQjN_P92wDIATSOgiv-G0UtqFg</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>de Figueiredo, Paul</creator><creator>Terra, Becky</creator><creator>Anand, Jasbir Kaur</creator><creator>Hikita, Toshiyuki</creator><creator>Sadilek, Martin</creator><creator>Monks, Dave E</creator><creator>Lenskiy, Anastasiya</creator><creator>Hakomori, Senitiroh</creator><creator>Nester, Eugene W</creator><general>Tokyo : Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H95</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>catalytic carbohydrate contributes to bacterial antibiotic resistance</title><author>de Figueiredo, Paul ; Terra, Becky ; Anand, Jasbir Kaur ; Hikita, Toshiyuki ; Sadilek, Martin ; Monks, Dave E ; Lenskiy, Anastasiya ; Hakomori, Senitiroh ; Nester, Eugene W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-eddf8acb80a91adde3911eabdb0700e3aa10bdc5a90592e5c88d4fde14ecfa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alkaliphile</topic><topic>Ampicillin - metabolism</topic><topic>Ampicillin - pharmacology</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Bacillus subtilis - drug effects</topic><topic>Bacillus subtilis - growth & development</topic><topic>Bacillus subtilis - metabolism</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>beta-Cyclodextrins - metabolism</topic><topic>beta-Lactamases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates</topic><topic>Catalysis</topic><topic>catalytic activity</topic><topic>Cyclodextrin</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - growth & development</topic><topic>Escherichia coli - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydrolysis</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Penicillin</topic><topic>Penicillin Resistance</topic><topic>Resistance</topic><topic>Space life sciences</topic><topic>Starch - metabolism</topic><topic>β-lactamase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Figueiredo, Paul</creatorcontrib><creatorcontrib>Terra, Becky</creatorcontrib><creatorcontrib>Anand, Jasbir Kaur</creatorcontrib><creatorcontrib>Hikita, Toshiyuki</creatorcontrib><creatorcontrib>Sadilek, Martin</creatorcontrib><creatorcontrib>Monks, Dave E</creatorcontrib><creatorcontrib>Lenskiy, Anastasiya</creatorcontrib><creatorcontrib>Hakomori, Senitiroh</creatorcontrib><creatorcontrib>Nester, Eugene W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Extremophiles : life under extreme conditions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Figueiredo, Paul</au><au>Terra, Becky</au><au>Anand, Jasbir Kaur</au><au>Hikita, Toshiyuki</au><au>Sadilek, Martin</au><au>Monks, Dave E</au><au>Lenskiy, Anastasiya</au><au>Hakomori, Senitiroh</au><au>Nester, Eugene W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>catalytic carbohydrate contributes to bacterial antibiotic resistance</atitle><jtitle>Extremophiles : life under extreme conditions</jtitle><addtitle>Extremophiles</addtitle><date>2007</date><risdate>2007</risdate><volume>11</volume><issue>1</issue><spage>133</spage><epage>143</epage><pages>133-143</pages><issn>1431-0651</issn><eissn>1433-4909</eissn><abstract>Penicillins are widespread in nature and lethal to growing bacteria. Because of the severe threat posed by these antibiotics, bacteria have evolved a wide variety of strategies for combating them. Here, we describe one unusual strategy that involves the activity of a catalytic carbohydrate. We show that the cyclic oligosaccharide, β-cyclodextrin (βCD), can hydrolyze, and thereby inactivate, penicillin in vivo. Moreover, we demonstrate that this catalytic activity contributes to the antibiotic resistance of a bacterium that synthesizes this oligosaccharide in the laboratory. Taken together, these data not only expand our understanding of the biochemistry of penicillin resistance, but also provide the first demonstration of natural carbohydrate-mediated catalysis in a living system.</abstract><cop>Heidelberg</cop><cop>Tokyo</cop><pub>Tokyo : Springer-Verlag</pub><pmid>17048043</pmid><doi>10.1007/s00792-006-0024-3</doi><tpages>11</tpages></addata></record> |
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| subjects | Alkaliphile Ampicillin - metabolism Ampicillin - pharmacology Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Bacillus subtilis - drug effects Bacillus subtilis - growth & development Bacillus subtilis - metabolism Bacteria Bacteriology beta-Cyclodextrins - metabolism beta-Lactamases - metabolism Biological and medical sciences Carbohydrates Catalysis catalytic activity Cyclodextrin Escherichia coli - drug effects Escherichia coli - growth & development Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Hydrolysis Microbial Sensitivity Tests Microbiology Miscellaneous Penicillin Penicillin Resistance Resistance Space life sciences Starch - metabolism β-lactamase |
| title | catalytic carbohydrate contributes to bacterial antibiotic resistance |
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