microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells

► miR-195 is downregulated in human CRC tissues and cell lines. ► miR-195 reduces cell viability, promotes apoptosis and suppresses tumorigenicity. ► Antiapoptotic Bcl-2 is a direct target of miR-195. ► Proapoptotic effect of miR-195 is mainly through targeting Bcl-2. Deregulated microRNAs and their...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2010-09, Vol.400 (2), p.236-240
Hauptverfasser:	Liu, Lin, Chen, Lin, Xu, Yingxin, Li, Rong, Du, Xiaohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apoptosis Apoptosis - genetics Bcl-2 Cell Transformation, Neoplastic - genetics Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Down-Regulation Female Gene Expression Regulation, Neoplastic Genes, bcl-2 - genetics Genes, Tumor Suppressor Humans Male microRNA MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-195
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!