Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q 1 . We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription f...
Gespeichert in:
| Veröffentlicht in: | Nature genetics 2006-03, Vol.38 (3), p.320-323 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 323 |
|---|---|
| container_issue | 3 |
| container_start_page | 320 |
| container_title | Nature genetics |
| container_volume | 38 |
| creator | Grant, Struan F A Thorleifsson, Gudmar Reynisdottir, Inga Benediktsson, Rafn Manolescu, Andrei Sainz, Jesus Helgason, Agnar Stefansson, Hreinn Emilsson, Valur Helgadottir, Anna Styrkarsdottir, Unnur Magnusson, Kristinn P Walters, G Bragi Palsdottir, Ebba Jonsdottir, Thorbjorg Gudmundsdottir, Thorunn Gylfason, Arnaldur Saemundsdottir, Jona Wilensky, Robert L Reilly, Muredach P Rader, Daniel J Bagger, Yu Christiansen, Claus Gudnason, Vilmundur Sigurdsson, Gunnar Thorsteinsdottir, Unnur Gulcher, Jeffrey R Kong, Augustine Stefansson, Kari |
| description | We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q
1
. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7–like 2 gene (
TCF7L2
; formerly
TCF4
) was associated with type 2 diabetes (
P
= 2.1 × 10
−9
). This was replicated in a Danish cohort (
P
= 4.8 × 10
−3
) and in a US cohort (
P
= 3.3 × 10
−9
). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The
TCF7L2
gene product is a high mobility group box–containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway
2
. |
| doi_str_mv | 10.1038/ng1732 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_864950300</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A183393848</galeid><sourcerecordid>A183393848</sourcerecordid><originalsourceid>FETCH-LOGICAL-c630t-868dd616929052430cf26f3a7ca68282f9ee387da6ed0067dda109b8f5e141d93</originalsourceid><addsrcrecordid>eNqN0t2L1DAQAPAiiveh_glSFD_uoWcmSfPxeCyeHiwc6LmvJZtOSu667Zq04P33l7qFZQ9RyUND-ptJZzpZ9grIORCmPnUNSEafZMdQclGABPU07YmAghMmjrKTGG8JAc6Jep4dgeBQKsWPs9XKBG-6Ie9dPgTTRRv8dvB9lztjhz7ksmj9HeY0_3izuJRLepY32GFu-85hiHnw8e537P12QrU3axwwvsieOdNGfDk_T7Mfl59vFl-L5fWXq8XFsrCCkaFQQtW1AKGpJiXljFhHhWNGWiMUVdRpRKZkbQTWhAhZ1waIXitXInCoNTvNPuzybkP_c8Q4VBsfLbat6bAfY6UE1yVhhCT5_q9SyPQVHOg_IWhdagbT3W8ewdt-DF0qt6KUCkGEVgm93aHGtFj5zvWpy3bKWF2AYkwzxSd1_geVVo0bn1qNzqfzg4Czg4BkBvw1NGaMsbr6_u3_7fXq0M7F29DHGNBV2-A3JtxXQKpp0KrdoCX4ei5-XG-w3rN5shJ4NwMTrWldmi3r495JCRQk3__BmF51DYZ9Fx9d-QCreN_A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222660698</pqid></control><display><type>article</type><title>Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><creator>Grant, Struan F A ; Thorleifsson, Gudmar ; Reynisdottir, Inga ; Benediktsson, Rafn ; Manolescu, Andrei ; Sainz, Jesus ; Helgason, Agnar ; Stefansson, Hreinn ; Emilsson, Valur ; Helgadottir, Anna ; Styrkarsdottir, Unnur ; Magnusson, Kristinn P ; Walters, G Bragi ; Palsdottir, Ebba ; Jonsdottir, Thorbjorg ; Gudmundsdottir, Thorunn ; Gylfason, Arnaldur ; Saemundsdottir, Jona ; Wilensky, Robert L ; Reilly, Muredach P ; Rader, Daniel J ; Bagger, Yu ; Christiansen, Claus ; Gudnason, Vilmundur ; Sigurdsson, Gunnar ; Thorsteinsdottir, Unnur ; Gulcher, Jeffrey R ; Kong, Augustine ; Stefansson, Kari</creator><creatorcontrib>Grant, Struan F A ; Thorleifsson, Gudmar ; Reynisdottir, Inga ; Benediktsson, Rafn ; Manolescu, Andrei ; Sainz, Jesus ; Helgason, Agnar ; Stefansson, Hreinn ; Emilsson, Valur ; Helgadottir, Anna ; Styrkarsdottir, Unnur ; Magnusson, Kristinn P ; Walters, G Bragi ; Palsdottir, Ebba ; Jonsdottir, Thorbjorg ; Gudmundsdottir, Thorunn ; Gylfason, Arnaldur ; Saemundsdottir, Jona ; Wilensky, Robert L ; Reilly, Muredach P ; Rader, Daniel J ; Bagger, Yu ; Christiansen, Claus ; Gudnason, Vilmundur ; Sigurdsson, Gunnar ; Thorsteinsdottir, Unnur ; Gulcher, Jeffrey R ; Kong, Augustine ; Stefansson, Kari</creatorcontrib><description>We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q
1
. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7–like 2 gene (
TCF7L2
; formerly
TCF4
) was associated with type 2 diabetes (
P
= 2.1 × 10
−9
). This was replicated in a Danish cohort (
P
= 4.8 × 10
−3
) and in a US cohort (
P
= 3.3 × 10
−9
). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The
TCF7L2
gene product is a high mobility group box–containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway
2
.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng1732</identifier><identifier>PMID: 16415884</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Agriculture ; Animal Genetics and Genomics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Cancer Research ; Causes of ; Chromosome Mapping ; Chromosomes, Human, Pair 10 ; Cohort Studies ; Denmark ; Diabetes ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; DNA binding proteins ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Gene Function ; Genetic aspects ; Genetic Carrier Screening ; Genetic Predisposition to Disease ; Genetic variation ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype & phenotype ; Health aspects ; Human Genetics ; Humans ; Introns ; letter ; Medical sciences ; Microsatellite Repeats ; Molecular Sequence Data ; Physiological aspects ; Population ; Reference Values ; TCF Transcription Factors - genetics ; Transcription Factor 7-Like 2 Protein ; Type 2 diabetes</subject><ispartof>Nature genetics, 2006-03, Vol.38 (3), p.320-323</ispartof><rights>Springer Nature America, Inc. 2006</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c630t-868dd616929052430cf26f3a7ca68282f9ee387da6ed0067dda109b8f5e141d93</citedby><cites>FETCH-LOGICAL-c630t-868dd616929052430cf26f3a7ca68282f9ee387da6ed0067dda109b8f5e141d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng1732$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng1732$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17712174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16415884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grant, Struan F A</creatorcontrib><creatorcontrib>Thorleifsson, Gudmar</creatorcontrib><creatorcontrib>Reynisdottir, Inga</creatorcontrib><creatorcontrib>Benediktsson, Rafn</creatorcontrib><creatorcontrib>Manolescu, Andrei</creatorcontrib><creatorcontrib>Sainz, Jesus</creatorcontrib><creatorcontrib>Helgason, Agnar</creatorcontrib><creatorcontrib>Stefansson, Hreinn</creatorcontrib><creatorcontrib>Emilsson, Valur</creatorcontrib><creatorcontrib>Helgadottir, Anna</creatorcontrib><creatorcontrib>Styrkarsdottir, Unnur</creatorcontrib><creatorcontrib>Magnusson, Kristinn P</creatorcontrib><creatorcontrib>Walters, G Bragi</creatorcontrib><creatorcontrib>Palsdottir, Ebba</creatorcontrib><creatorcontrib>Jonsdottir, Thorbjorg</creatorcontrib><creatorcontrib>Gudmundsdottir, Thorunn</creatorcontrib><creatorcontrib>Gylfason, Arnaldur</creatorcontrib><creatorcontrib>Saemundsdottir, Jona</creatorcontrib><creatorcontrib>Wilensky, Robert L</creatorcontrib><creatorcontrib>Reilly, Muredach P</creatorcontrib><creatorcontrib>Rader, Daniel J</creatorcontrib><creatorcontrib>Bagger, Yu</creatorcontrib><creatorcontrib>Christiansen, Claus</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Sigurdsson, Gunnar</creatorcontrib><creatorcontrib>Thorsteinsdottir, Unnur</creatorcontrib><creatorcontrib>Gulcher, Jeffrey R</creatorcontrib><creatorcontrib>Kong, Augustine</creatorcontrib><creatorcontrib>Stefansson, Kari</creatorcontrib><title>Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q
1
. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7–like 2 gene (
TCF7L2
; formerly
TCF4
) was associated with type 2 diabetes (
P
= 2.1 × 10
−9
). This was replicated in a Danish cohort (
P
= 4.8 × 10
−3
) and in a US cohort (
P
= 3.3 × 10
−9
). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The
TCF7L2
gene product is a high mobility group box–containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway
2
.</description><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Cancer Research</subject><subject>Causes of</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 10</subject><subject>Cohort Studies</subject><subject>Denmark</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA binding proteins</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic Carrier Screening</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic variation</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Introns</subject><subject>letter</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>Molecular Sequence Data</subject><subject>Physiological aspects</subject><subject>Population</subject><subject>Reference Values</subject><subject>TCF Transcription Factors - genetics</subject><subject>Transcription Factor 7-Like 2 Protein</subject><subject>Type 2 diabetes</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0t2L1DAQAPAiiveh_glSFD_uoWcmSfPxeCyeHiwc6LmvJZtOSu667Zq04P33l7qFZQ9RyUND-ptJZzpZ9grIORCmPnUNSEafZMdQclGABPU07YmAghMmjrKTGG8JAc6Jep4dgeBQKsWPs9XKBG-6Ie9dPgTTRRv8dvB9lztjhz7ksmj9HeY0_3izuJRLepY32GFu-85hiHnw8e537P12QrU3axwwvsieOdNGfDk_T7Mfl59vFl-L5fWXq8XFsrCCkaFQQtW1AKGpJiXljFhHhWNGWiMUVdRpRKZkbQTWhAhZ1waIXitXInCoNTvNPuzybkP_c8Q4VBsfLbat6bAfY6UE1yVhhCT5_q9SyPQVHOg_IWhdagbT3W8ewdt-DF0qt6KUCkGEVgm93aHGtFj5zvWpy3bKWF2AYkwzxSd1_geVVo0bn1qNzqfzg4Czg4BkBvw1NGaMsbr6_u3_7fXq0M7F29DHGNBV2-A3JtxXQKpp0KrdoCX4ei5-XG-w3rN5shJ4NwMTrWldmi3r495JCRQk3__BmF51DYZ9Fx9d-QCreN_A</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Grant, Struan F A</creator><creator>Thorleifsson, Gudmar</creator><creator>Reynisdottir, Inga</creator><creator>Benediktsson, Rafn</creator><creator>Manolescu, Andrei</creator><creator>Sainz, Jesus</creator><creator>Helgason, Agnar</creator><creator>Stefansson, Hreinn</creator><creator>Emilsson, Valur</creator><creator>Helgadottir, Anna</creator><creator>Styrkarsdottir, Unnur</creator><creator>Magnusson, Kristinn P</creator><creator>Walters, G Bragi</creator><creator>Palsdottir, Ebba</creator><creator>Jonsdottir, Thorbjorg</creator><creator>Gudmundsdottir, Thorunn</creator><creator>Gylfason, Arnaldur</creator><creator>Saemundsdottir, Jona</creator><creator>Wilensky, Robert L</creator><creator>Reilly, Muredach P</creator><creator>Rader, Daniel J</creator><creator>Bagger, Yu</creator><creator>Christiansen, Claus</creator><creator>Gudnason, Vilmundur</creator><creator>Sigurdsson, Gunnar</creator><creator>Thorsteinsdottir, Unnur</creator><creator>Gulcher, Jeffrey R</creator><creator>Kong, Augustine</creator><creator>Stefansson, Kari</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060301</creationdate><title>Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes</title><author>Grant, Struan F A ; Thorleifsson, Gudmar ; Reynisdottir, Inga ; Benediktsson, Rafn ; Manolescu, Andrei ; Sainz, Jesus ; Helgason, Agnar ; Stefansson, Hreinn ; Emilsson, Valur ; Helgadottir, Anna ; Styrkarsdottir, Unnur ; Magnusson, Kristinn P ; Walters, G Bragi ; Palsdottir, Ebba ; Jonsdottir, Thorbjorg ; Gudmundsdottir, Thorunn ; Gylfason, Arnaldur ; Saemundsdottir, Jona ; Wilensky, Robert L ; Reilly, Muredach P ; Rader, Daniel J ; Bagger, Yu ; Christiansen, Claus ; Gudnason, Vilmundur ; Sigurdsson, Gunnar ; Thorsteinsdottir, Unnur ; Gulcher, Jeffrey R ; Kong, Augustine ; Stefansson, Kari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-868dd616929052430cf26f3a7ca68282f9ee387da6ed0067dda109b8f5e141d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood</topic><topic>Cancer Research</topic><topic>Causes of</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 10</topic><topic>Cohort Studies</topic><topic>Denmark</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA binding proteins</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic Carrier Screening</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic variation</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype & phenotype</topic><topic>Health aspects</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Introns</topic><topic>letter</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>Molecular Sequence Data</topic><topic>Physiological aspects</topic><topic>Population</topic><topic>Reference Values</topic><topic>TCF Transcription Factors - genetics</topic><topic>Transcription Factor 7-Like 2 Protein</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grant, Struan F A</creatorcontrib><creatorcontrib>Thorleifsson, Gudmar</creatorcontrib><creatorcontrib>Reynisdottir, Inga</creatorcontrib><creatorcontrib>Benediktsson, Rafn</creatorcontrib><creatorcontrib>Manolescu, Andrei</creatorcontrib><creatorcontrib>Sainz, Jesus</creatorcontrib><creatorcontrib>Helgason, Agnar</creatorcontrib><creatorcontrib>Stefansson, Hreinn</creatorcontrib><creatorcontrib>Emilsson, Valur</creatorcontrib><creatorcontrib>Helgadottir, Anna</creatorcontrib><creatorcontrib>Styrkarsdottir, Unnur</creatorcontrib><creatorcontrib>Magnusson, Kristinn P</creatorcontrib><creatorcontrib>Walters, G Bragi</creatorcontrib><creatorcontrib>Palsdottir, Ebba</creatorcontrib><creatorcontrib>Jonsdottir, Thorbjorg</creatorcontrib><creatorcontrib>Gudmundsdottir, Thorunn</creatorcontrib><creatorcontrib>Gylfason, Arnaldur</creatorcontrib><creatorcontrib>Saemundsdottir, Jona</creatorcontrib><creatorcontrib>Wilensky, Robert L</creatorcontrib><creatorcontrib>Reilly, Muredach P</creatorcontrib><creatorcontrib>Rader, Daniel J</creatorcontrib><creatorcontrib>Bagger, Yu</creatorcontrib><creatorcontrib>Christiansen, Claus</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Sigurdsson, Gunnar</creatorcontrib><creatorcontrib>Thorsteinsdottir, Unnur</creatorcontrib><creatorcontrib>Gulcher, Jeffrey R</creatorcontrib><creatorcontrib>Kong, Augustine</creatorcontrib><creatorcontrib>Stefansson, Kari</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grant, Struan F A</au><au>Thorleifsson, Gudmar</au><au>Reynisdottir, Inga</au><au>Benediktsson, Rafn</au><au>Manolescu, Andrei</au><au>Sainz, Jesus</au><au>Helgason, Agnar</au><au>Stefansson, Hreinn</au><au>Emilsson, Valur</au><au>Helgadottir, Anna</au><au>Styrkarsdottir, Unnur</au><au>Magnusson, Kristinn P</au><au>Walters, G Bragi</au><au>Palsdottir, Ebba</au><au>Jonsdottir, Thorbjorg</au><au>Gudmundsdottir, Thorunn</au><au>Gylfason, Arnaldur</au><au>Saemundsdottir, Jona</au><au>Wilensky, Robert L</au><au>Reilly, Muredach P</au><au>Rader, Daniel J</au><au>Bagger, Yu</au><au>Christiansen, Claus</au><au>Gudnason, Vilmundur</au><au>Sigurdsson, Gunnar</au><au>Thorsteinsdottir, Unnur</au><au>Gulcher, Jeffrey R</au><au>Kong, Augustine</au><au>Stefansson, Kari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>38</volume><issue>3</issue><spage>320</spage><epage>323</epage><pages>320-323</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q
1
. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controls throughout a 10.5-Mb interval on 10q. A microsatellite, DG10S478, within intron 3 of the transcription factor 7–like 2 gene (
TCF7L2
; formerly
TCF4
) was associated with type 2 diabetes (
P
= 2.1 × 10
−9
). This was replicated in a Danish cohort (
P
= 4.8 × 10
−3
) and in a US cohort (
P
= 3.3 × 10
−9
). Compared with non-carriers, heterozygous and homozygous carriers of the at-risk alleles (38% and 7% of the population, respectively) have relative risks of 1.45 and 2.41. This corresponds to a population attributable risk of 21%. The
TCF7L2
gene product is a high mobility group box–containing transcription factor previously implicated in blood glucose homeostasis. It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway
2
.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16415884</pmid><doi>10.1038/ng1732</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 2006-03, Vol.38 (3), p.320-323 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_864950300 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood Cancer Research Causes of Chromosome Mapping Chromosomes, Human, Pair 10 Cohort Studies Denmark Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance DNA binding proteins Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Genetic aspects Genetic Carrier Screening Genetic Predisposition to Disease Genetic variation Genetics of eukaryotes. Biological and molecular evolution Genotype & phenotype Health aspects Human Genetics Humans Introns letter Medical sciences Microsatellite Repeats Molecular Sequence Data Physiological aspects Population Reference Values TCF Transcription Factors - genetics Transcription Factor 7-Like 2 Protein Type 2 diabetes |
| title | Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T10%3A35%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Variant%20of%20transcription%20factor%207-like%202%20(TCF7L2)%20gene%20confers%20risk%20of%20type%202%20diabetes&rft.jtitle=Nature%20genetics&rft.au=Grant,%20Struan%20F%20A&rft.date=2006-03-01&rft.volume=38&rft.issue=3&rft.spage=320&rft.epage=323&rft.pages=320-323&rft.issn=1061-4036&rft.eissn=1546-1718&rft.coden=NGENEC&rft_id=info:doi/10.1038/ng1732&rft_dat=%3Cgale_proqu%3EA183393848%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222660698&rft_id=info:pmid/16415884&rft_galeid=A183393848&rfr_iscdi=true |