Recombinant protein production in yeasts
Recombinant DNA (rDNA) technologies (genetic, protein, and metabolic engineering) allow the production of a wide range of peptides, proteins, and biochemicals from naturally nonproducing cells. These technologies, now approx 25 yr old, have become one of the most important technologies developed in...
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| Veröffentlicht in: | Molecular biotechnology 2005-11, Vol.31 (3), p.245-259 |
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| creator | PORRO, Danilo SAUER, Michael BRANDUARDI, Paola MATTANOVICH, Diethard |
| description | Recombinant DNA (rDNA) technologies (genetic, protein, and metabolic engineering) allow the production of a wide range of peptides, proteins, and biochemicals from naturally nonproducing cells. These technologies, now approx 25 yr old, have become one of the most important technologies developed in the twentieth century. Pharmaceutical products and industrial enzymes were the first biotech products on the world market made by means of rDNA. Despite important advances in rDNA applications in mammalian cells, yeasts still represent attractive hosts for the production of heterologous proteins. In this review we summarize advantages and limitations of the main and most promising yeast hosts. |
| doi_str_mv | 10.1385/MB:31:3:245 |
| format | Article |
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| language | eng |
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| subjects | Biological and medical sciences Biotechnology Fermentation Fundamental and applied biological sciences. Psychology Peptides Promoter Regions, Genetic Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - economics Recombinant Proteins - genetics Recombinant Proteins - secretion Transformation, Genetic Yeasts Yeasts - genetics |
| title | Recombinant protein production in yeasts |
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