Antimicrobial susceptibility and resistance determinants of Clostridium butyricum isolates from preterm infants
Abstract This study reports the antibiotic susceptibility and genetic resistance determinants of 39 Clostridium butyricum strains isolated from the faeces of preterm infants as well as one reference strain. Results showed that all the strains were susceptible to cefoxitin, imipenem, vancomycin, tige...
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| Veröffentlicht in: | International journal of antimicrobial agents 2010-11, Vol.36 (5), p.420-423 |
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| creator | Ferraris, Laurent Butel, Marie-José Aires, Julio |
| description | Abstract This study reports the antibiotic susceptibility and genetic resistance determinants of 39 Clostridium butyricum strains isolated from the faeces of preterm infants as well as one reference strain. Results showed that all the strains were susceptible to cefoxitin, imipenem, vancomycin, tigecycline, metronidazole, chloramphenicol and linezolid. Resistance was observed to clindamycin (100%), penicillin G, amoxicillin and piperacillin (15%), tetracycline (7.5%) and erythromycin (5%). Investigation of the genetic basis of the observed resistance phenotypes showed that resistance to penicillin was due to β-lactamase activity and that resistance to tetracycline involved tet (O) or tet (O/32/O) homologue genes. Clindamycin and erythromycin resistance may involve another genetic determinant, different from those commonly described for clostridia. |
| doi_str_mv | 10.1016/j.ijantimicag.2010.07.005 |
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Results showed that all the strains were susceptible to cefoxitin, imipenem, vancomycin, tigecycline, metronidazole, chloramphenicol and linezolid. Resistance was observed to clindamycin (100%), penicillin G, amoxicillin and piperacillin (15%), tetracycline (7.5%) and erythromycin (5%). Investigation of the genetic basis of the observed resistance phenotypes showed that resistance to penicillin was due to β-lactamase activity and that resistance to tetracycline involved tet (O) or tet (O/32/O) homologue genes. Clindamycin and erythromycin resistance may involve another genetic determinant, different from those commonly described for clostridia.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2010.07.005</identifier><identifier>PMID: 20822886</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amoxicillin ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Clostridium butyricum ; Clostridium butyricum - drug effects ; Clostridium butyricum - isolation & purification ; Clostridium Infections - microbiology ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; Drug Resistance, Bacterial ; Feces - microbiology ; Genes, Bacterial ; Humans ; Infant ; Infectious Disease ; Medical sciences ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Premature Birth ; Preterm infants ; Sequence Analysis, DNA</subject><ispartof>International journal of antimicrobial agents, 2010-11, Vol.36 (5), p.420-423</ispartof><rights>Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2010 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-cf4766904683adb16f1afc9da0cc800b9bdfea2fb95b1b68c085fb50cb45b7d13</citedby><cites>FETCH-LOGICAL-c610t-cf4766904683adb16f1afc9da0cc800b9bdfea2fb95b1b68c085fb50cb45b7d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijantimicag.2010.07.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23356054$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20822886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferraris, Laurent</creatorcontrib><creatorcontrib>Butel, Marie-José</creatorcontrib><creatorcontrib>Aires, Julio</creatorcontrib><title>Antimicrobial susceptibility and resistance determinants of Clostridium butyricum isolates from preterm infants</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>Abstract This study reports the antibiotic susceptibility and genetic resistance determinants of 39 Clostridium butyricum strains isolated from the faeces of preterm infants as well as one reference strain. Results showed that all the strains were susceptible to cefoxitin, imipenem, vancomycin, tigecycline, metronidazole, chloramphenicol and linezolid. Resistance was observed to clindamycin (100%), penicillin G, amoxicillin and piperacillin (15%), tetracycline (7.5%) and erythromycin (5%). Investigation of the genetic basis of the observed resistance phenotypes showed that resistance to penicillin was due to β-lactamase activity and that resistance to tetracycline involved tet (O) or tet (O/32/O) homologue genes. Clindamycin and erythromycin resistance may involve another genetic determinant, different from those commonly described for clostridia.</description><subject>Amoxicillin</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Clostridium butyricum</subject><subject>Clostridium butyricum - drug effects</subject><subject>Clostridium butyricum - isolation & purification</subject><subject>Clostridium Infections - microbiology</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>Drug Resistance, Bacterial</subject><subject>Feces - microbiology</subject><subject>Genes, Bacterial</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious Disease</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Sequence Data</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Premature Birth</subject><subject>Preterm infants</subject><subject>Sequence Analysis, DNA</subject><issn>0924-8579</issn><issn>1872-7913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2v1CAUhonReMerf8HUhXHV8dAWChuTm4lfyU1cqGsCFMyptB2B3mT-vdQZP-JGVxDyvAc4zyHkGYU9Bcpfjnsc9ZxxQqu_7Bso59DvAdg9sqOib-pe0vY-2YFsulqwXl6RRymNAJS1HXtIrhoQTSME35Hl5lwnLgZ1qNKarDtmNBgwnyo9D1V0CVPWs3XV4LKLE87l7lQtvjqEJeWIA65TZdZ8imjLDtMSdHap8nGZqmP8Eapw9lvsMXngdUjuyWW9Jp_fvP50eFfffnj7_nBzW1tOIdfWdz3nEjouWj0Yyj3V3spBg7UCwEgzeKcbbyQz1HBhQTBvGFjTMdMPtL0mL851j3H5trqU1YTlayHo2S1rUoJ3spMl9U-yZ33HWyr7QsozWbqVUnReHSNOOp4UBbWJUaP6Q4zaxCjoVRFTsk8vt6xmcsOv5E8TBXh-AXSyOvhYOo7pN9e2jAPrCnc4c6507w5dVMmiK3YGjM5mNSz4X8959VcVG3AuWPjqTi6NyxrnokdRlRoF6uM2SdsgUQBo20a03wGR3sqw</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Ferraris, Laurent</creator><creator>Butel, Marie-José</creator><creator>Aires, Julio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20101101</creationdate><title>Antimicrobial susceptibility and resistance determinants of Clostridium butyricum isolates from preterm infants</title><author>Ferraris, Laurent ; Butel, Marie-José ; Aires, Julio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-cf4766904683adb16f1afc9da0cc800b9bdfea2fb95b1b68c085fb50cb45b7d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amoxicillin</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Clostridium butyricum</topic><topic>Clostridium butyricum - drug effects</topic><topic>Clostridium butyricum - isolation & purification</topic><topic>Clostridium Infections - microbiology</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>Drug Resistance, Bacterial</topic><topic>Feces - microbiology</topic><topic>Genes, Bacterial</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious Disease</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Sequence Data</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Premature Birth</topic><topic>Preterm infants</topic><topic>Sequence Analysis, DNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferraris, Laurent</creatorcontrib><creatorcontrib>Butel, Marie-José</creatorcontrib><creatorcontrib>Aires, Julio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of antimicrobial agents</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferraris, Laurent</au><au>Butel, Marie-José</au><au>Aires, Julio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial susceptibility and resistance determinants of Clostridium butyricum isolates from preterm infants</atitle><jtitle>International journal of antimicrobial agents</jtitle><addtitle>Int J Antimicrob Agents</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>36</volume><issue>5</issue><spage>420</spage><epage>423</epage><pages>420-423</pages><issn>0924-8579</issn><eissn>1872-7913</eissn><abstract>Abstract This study reports the antibiotic susceptibility and genetic resistance determinants of 39 Clostridium butyricum strains isolated from the faeces of preterm infants as well as one reference strain. 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| subjects | Amoxicillin Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clostridium butyricum Clostridium butyricum - drug effects Clostridium butyricum - isolation & purification Clostridium Infections - microbiology DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug Resistance, Bacterial Feces - microbiology Genes, Bacterial Humans Infant Infectious Disease Medical sciences Microbial Sensitivity Tests Molecular Sequence Data Pharmacology. Drug treatments Polymerase Chain Reaction Premature Birth Preterm infants Sequence Analysis, DNA |
| title | Antimicrobial susceptibility and resistance determinants of Clostridium butyricum isolates from preterm infants |
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