Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties
The purpose of this study was to develop spherical mesocellular foam (MCF) loaded with a poorly water-soluble drug, intended to be orally administered, able to improve the dissolution rate and enhance the drug loading capacity. Spherical MCF with a continuous 3-D pore system was synthesized using Pl...
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| Veröffentlicht in: | International journal of pharmaceutics 2011-05, Vol.410 (1), p.118-124 |
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| creator | Zhang, Yanzhuo Zhang, Jinghai Jiang, Tongying Wang, Siling |
| description | The purpose of this study was to develop spherical mesocellular foam (MCF) loaded with a poorly water-soluble drug, intended to be orally administered, able to improve the dissolution rate and enhance the drug loading capacity. Spherical MCF with a continuous 3-D pore system was synthesized using Pluronic 123 triblock polymer (P123) as a surfactant coupled with cetyltrimethyl ammonium bromide (CTAB) as a co-surfactant. A model drug, simvastatin (SV), was loaded onto spherical MCF via a procedure involving a combination of adsorption equilibrium and solvent evaporation. The drug release rate and the drug loading efficiency of spherical MCF were compared with those of fibrous SBA-15. Investigations using nitrogen adsorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and HPLC demonstrated the successful incorporation of SV into the MCF host. It was found that spherical MCF has a high drug loading efficiency up to 37.5%, and higher than that of fibrous SBA-15 with a pore diameter of 6.5
nm. It is worth noting that fast release rate of SV was obtained from spherical MCF compared with SBA-15 and pure crystalline SV using enzyme-free simulated intestinal fluid (SIF, pH 6.8). |
| doi_str_mv | 10.1016/j.ijpharm.2010.07.040 |
| format | Article |
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nm. It is worth noting that fast release rate of SV was obtained from spherical MCF compared with SBA-15 and pure crystalline SV using enzyme-free simulated intestinal fluid (SIF, pH 6.8).</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2010.07.040</identifier><identifier>PMID: 20674729</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Oral ; adsorption ; Biological and medical sciences ; Cetrimonium ; Cetrimonium Compounds - chemistry ; Crystallization ; differential scanning calorimetry ; Drug delivery ; Drug loading ; drugs ; Enhanced dissolution ; evaporation ; foams ; General pharmacology ; high performance liquid chromatography ; Medical sciences ; Mesocellular foam ; Nanoparticles ; nitrogen ; oral administration ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Poloxalene - chemistry ; polymers ; Poorly water-soluble drugs ; scanning electron microscopy ; Simvastatin ; Simvastatin - administration & dosage ; Simvastatin - chemistry ; Solubility ; solvents ; Solvents - chemistry ; Surface-Active Agents - chemistry ; surfactants ; thermogravimetry ; transmission electron microscopy ; X-ray diffraction</subject><ispartof>International journal of pharmaceutics, 2011-05, Vol.410 (1), p.118-124</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-54707574912e363eb50601f52248b3201e6cbdd5cd93d02e7a0f1f70f932b4143</citedby><cites>FETCH-LOGICAL-c418t-54707574912e363eb50601f52248b3201e6cbdd5cd93d02e7a0f1f70f932b4143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2010.07.040$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24195791$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20674729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yanzhuo</creatorcontrib><creatorcontrib>Zhang, Jinghai</creatorcontrib><creatorcontrib>Jiang, Tongying</creatorcontrib><creatorcontrib>Wang, Siling</creatorcontrib><title>Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The purpose of this study was to develop spherical mesocellular foam (MCF) loaded with a poorly water-soluble drug, intended to be orally administered, able to improve the dissolution rate and enhance the drug loading capacity. Spherical MCF with a continuous 3-D pore system was synthesized using Pluronic 123 triblock polymer (P123) as a surfactant coupled with cetyltrimethyl ammonium bromide (CTAB) as a co-surfactant. A model drug, simvastatin (SV), was loaded onto spherical MCF via a procedure involving a combination of adsorption equilibrium and solvent evaporation. The drug release rate and the drug loading efficiency of spherical MCF were compared with those of fibrous SBA-15. Investigations using nitrogen adsorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and HPLC demonstrated the successful incorporation of SV into the MCF host. It was found that spherical MCF has a high drug loading efficiency up to 37.5%, and higher than that of fibrous SBA-15 with a pore diameter of 6.5
nm. It is worth noting that fast release rate of SV was obtained from spherical MCF compared with SBA-15 and pure crystalline SV using enzyme-free simulated intestinal fluid (SIF, pH 6.8).</description><subject>Administration, Oral</subject><subject>adsorption</subject><subject>Biological and medical sciences</subject><subject>Cetrimonium</subject><subject>Cetrimonium Compounds - chemistry</subject><subject>Crystallization</subject><subject>differential scanning calorimetry</subject><subject>Drug delivery</subject><subject>Drug loading</subject><subject>drugs</subject><subject>Enhanced dissolution</subject><subject>evaporation</subject><subject>foams</subject><subject>General pharmacology</subject><subject>high performance liquid chromatography</subject><subject>Medical sciences</subject><subject>Mesocellular foam</subject><subject>Nanoparticles</subject><subject>nitrogen</subject><subject>oral administration</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Poloxalene - chemistry</subject><subject>polymers</subject><subject>Poorly water-soluble drugs</subject><subject>scanning electron microscopy</subject><subject>Simvastatin</subject><subject>Simvastatin - administration & dosage</subject><subject>Simvastatin - chemistry</subject><subject>Solubility</subject><subject>solvents</subject><subject>Solvents - chemistry</subject><subject>Surface-Active Agents - chemistry</subject><subject>surfactants</subject><subject>thermogravimetry</subject><subject>transmission electron microscopy</subject><subject>X-ray diffraction</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM-L1DAYhoso7uzqn6DmIp46fvnRpvUisq66sOBB9xzS5OtshjSpSbuyF_92M8yoRyEQCM-b9-WpqhcUthRo-3a_dfv5Tqdpy6C8gdyCgEfVhnaS11zI9nG1AS67uqGSn1XnOe8BoGWUP63OGLRSSNZvql_Xwfg1uxhIHMlyh2SOMfkH8lMvmOoc_Tp4JDatO5LddK_zohcXSDkT5mjQ-9XrRMaoJxJ0iLNOizMe8zvy8RDyUVsXdkQHSxJ61LlUpDhjwTA_q56M2md8frovqttPV98vv9Q3Xz9fX364qY2g3VI3QoJspOgpQ95yHBpogY4NY6IbeBGArRmsbYztuQWGUsNIRwljz9kgqOAX1Zvjv6X6x4p5UZPLh_E6YFyz6lohu0b2XSGbI2lSzDnhqObkJp0eFAV1MK_26mReHcwrkKqYL7mXp4Z1mND-Tf1RXYDXJ0Bno_2YdDAu_-ME7csAWrhXR27UUeldKsztt9LUAFAmGG0K8f5IYDF27zCpbBwGg9YlNIuy0f1n7G9CwK84</recordid><startdate>20110530</startdate><enddate>20110530</enddate><creator>Zhang, Yanzhuo</creator><creator>Zhang, Jinghai</creator><creator>Jiang, Tongying</creator><creator>Wang, Siling</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110530</creationdate><title>Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties</title><author>Zhang, Yanzhuo ; Zhang, Jinghai ; Jiang, Tongying ; Wang, Siling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-54707574912e363eb50601f52248b3201e6cbdd5cd93d02e7a0f1f70f932b4143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Oral</topic><topic>adsorption</topic><topic>Biological and medical sciences</topic><topic>Cetrimonium</topic><topic>Cetrimonium Compounds - chemistry</topic><topic>Crystallization</topic><topic>differential scanning calorimetry</topic><topic>Drug delivery</topic><topic>Drug loading</topic><topic>drugs</topic><topic>Enhanced dissolution</topic><topic>evaporation</topic><topic>foams</topic><topic>General pharmacology</topic><topic>high performance liquid chromatography</topic><topic>Medical sciences</topic><topic>Mesocellular foam</topic><topic>Nanoparticles</topic><topic>nitrogen</topic><topic>oral administration</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Poloxalene - chemistry</topic><topic>polymers</topic><topic>Poorly water-soluble drugs</topic><topic>scanning electron microscopy</topic><topic>Simvastatin</topic><topic>Simvastatin - administration & dosage</topic><topic>Simvastatin - chemistry</topic><topic>Solubility</topic><topic>solvents</topic><topic>Solvents - chemistry</topic><topic>Surface-Active Agents - chemistry</topic><topic>surfactants</topic><topic>thermogravimetry</topic><topic>transmission electron microscopy</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yanzhuo</creatorcontrib><creatorcontrib>Zhang, Jinghai</creatorcontrib><creatorcontrib>Jiang, Tongying</creatorcontrib><creatorcontrib>Wang, Siling</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yanzhuo</au><au>Zhang, Jinghai</au><au>Jiang, Tongying</au><au>Wang, Siling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2011-05-30</date><risdate>2011</risdate><volume>410</volume><issue>1</issue><spage>118</spage><epage>124</epage><pages>118-124</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>The purpose of this study was to develop spherical mesocellular foam (MCF) loaded with a poorly water-soluble drug, intended to be orally administered, able to improve the dissolution rate and enhance the drug loading capacity. Spherical MCF with a continuous 3-D pore system was synthesized using Pluronic 123 triblock polymer (P123) as a surfactant coupled with cetyltrimethyl ammonium bromide (CTAB) as a co-surfactant. A model drug, simvastatin (SV), was loaded onto spherical MCF via a procedure involving a combination of adsorption equilibrium and solvent evaporation. The drug release rate and the drug loading efficiency of spherical MCF were compared with those of fibrous SBA-15. Investigations using nitrogen adsorption, scanning electron microscopy (SEM), transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and HPLC demonstrated the successful incorporation of SV into the MCF host. It was found that spherical MCF has a high drug loading efficiency up to 37.5%, and higher than that of fibrous SBA-15 with a pore diameter of 6.5
nm. It is worth noting that fast release rate of SV was obtained from spherical MCF compared with SBA-15 and pure crystalline SV using enzyme-free simulated intestinal fluid (SIF, pH 6.8).</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20674729</pmid><doi>10.1016/j.ijpharm.2010.07.040</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Oral adsorption Biological and medical sciences Cetrimonium Cetrimonium Compounds - chemistry Crystallization differential scanning calorimetry Drug delivery Drug loading drugs Enhanced dissolution evaporation foams General pharmacology high performance liquid chromatography Medical sciences Mesocellular foam Nanoparticles nitrogen oral administration Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poloxalene - chemistry polymers Poorly water-soluble drugs scanning electron microscopy Simvastatin Simvastatin - administration & dosage Simvastatin - chemistry Solubility solvents Solvents - chemistry Surface-Active Agents - chemistry surfactants thermogravimetry transmission electron microscopy X-ray diffraction |
| title | Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties |
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