Differential and Synergistic Effects of Epidermal Growth Factor Receptor Antibodies on Unliganded ErbB Dimers and Oligomers

Antibodies directed against the epidermal growth factor receptor (EGFR) offer a potentially powerful therapeutic approach against cancers driven by the EGFR pathway. EGFR antibodies are believed to halt cell surface activation by blocking ligand-induced receptor tyrosine kinase activation, i.e., lig...

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Veröffentlicht in:	Biochemistry (Easton) 2011-05, Vol.50 (18), p.3581-3590
Hauptverfasser:	Kozer, Noga, Kelly, Marcus P, Orchard, Suzanne, Burgess, Antony W, Scott, Andrew M, Clayton, Andrew H. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisotropy Antibodies, Monoclonal - chemistry Cell Membrane - metabolism Cross-Linking Reagents - chemistry Dimerization Fluorescence Resonance Energy Transfer Green Fluorescent Proteins - chemistry Humans Ligands Mice Mutation Oncogene Proteins v-erbB - chemistry Protein Binding Protein Conformation Protein Structure, Quaternary Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - immunology
Online-Zugang:	Volltext
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