Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration
To evaluate the clinical relevance of the presence of lymphocytes in transbronchial needle aspiration (TBNA) samples from pathological mediastinal lymph nodes in patients with suspected lung cancer. Retrospective observational study evaluating the negative predictive value (NPV) of TBNA samples cont...
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| Veröffentlicht in: | Archivos de bronconeumología (English ed.) 2011-03, Vol.47 (3), p.122-127 |
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| container_title | Archivos de bronconeumología (English ed.) |
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| creator | Lucena, Carmen M Agustí, Carles Martínez-Olondris, Pilar Cano-Jiménez, Esteban Marrades, Ramón M Ramírez, Josep Sánchez, Marcelo Arguis, Pedro Xaubet, Antoni |
| description | To evaluate the clinical relevance of the presence of lymphocytes in transbronchial needle aspiration (TBNA) samples from pathological mediastinal lymph nodes in patients with suspected lung cancer.
Retrospective observational study evaluating the negative predictive value (NPV) of TBNA samples containing lymphocytes but not malignant cells.
A total of 266 TBNA were performed in 252 patients with pathological lymph nodes. One hundred and fifteen TBNA samples had evidence of malignant cells (43%), and 94 (35%) samples were considered as inadequate (absence of adequate cytological material or exclusive presence of bronchial epithelial cells). Out of the 57 TBNA samples remaining (21%), 15 could not be confirmed; in 32, TBNA samples were confirmed with alternative diagnostic techniques and in 10, they were confirmed after clinical and radiological follow-up. The NPV of the 32 samples that were confirmed with alternative diagnostic techniques was 84% decreasing down to 76% when the 10 TBNA samples confirmed after clinical and radiological follow-up were included.
The presence of lymphocytes in the TBNA sample does not exclude the neoplasic invasion of the specific lymph node analyzed. |
| doi_str_mv | 10.1016/j.arbres.2010.10.005 |
| format | Article |
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Retrospective observational study evaluating the negative predictive value (NPV) of TBNA samples containing lymphocytes but not malignant cells.
A total of 266 TBNA were performed in 252 patients with pathological lymph nodes. One hundred and fifteen TBNA samples had evidence of malignant cells (43%), and 94 (35%) samples were considered as inadequate (absence of adequate cytological material or exclusive presence of bronchial epithelial cells). Out of the 57 TBNA samples remaining (21%), 15 could not be confirmed; in 32, TBNA samples were confirmed with alternative diagnostic techniques and in 10, they were confirmed after clinical and radiological follow-up. The NPV of the 32 samples that were confirmed with alternative diagnostic techniques was 84% decreasing down to 76% when the 10 TBNA samples confirmed after clinical and radiological follow-up were included.
The presence of lymphocytes in the TBNA sample does not exclude the neoplasic invasion of the specific lymph node analyzed.</description><identifier>EISSN: 1579-2129</identifier><identifier>DOI: 10.1016/j.arbres.2010.10.005</identifier><identifier>PMID: 21277665</identifier><language>eng ; spa</language><publisher>Spain</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - secondary ; Aged ; Aged, 80 and over ; Biopsy, Needle - methods ; Bronchi ; Bronchoscopy ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - secondary ; Carcinoma, Small Cell - diagnostic imaging ; Carcinoma, Small Cell - secondary ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - secondary ; Colonic Neoplasms - pathology ; Female ; Humans ; Lung Neoplasms - diagnosis ; Lung Neoplasms - pathology ; Lymph Nodes - pathology ; Lymphatic Metastasis - diagnostic imaging ; Lymphatic Metastasis - pathology ; Lymphocyte Count ; Lymphocytes - pathology ; Male ; Mediastinum ; Melanoma - diagnostic imaging ; Melanoma - secondary ; Middle Aged ; Positron-Emission Tomography ; Predictive Value of Tests ; Retrospective Studies ; Single-Blind Method ; Skin Neoplasms - pathology</subject><ispartof>Archivos de bronconeumología (English ed.), 2011-03, Vol.47 (3), p.122-127</ispartof><rights>Copyright © 2010 SEPAR. Published by Elsevier Espana. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21277665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucena, Carmen M</creatorcontrib><creatorcontrib>Agustí, Carles</creatorcontrib><creatorcontrib>Martínez-Olondris, Pilar</creatorcontrib><creatorcontrib>Cano-Jiménez, Esteban</creatorcontrib><creatorcontrib>Marrades, Ramón M</creatorcontrib><creatorcontrib>Ramírez, Josep</creatorcontrib><creatorcontrib>Sánchez, Marcelo</creatorcontrib><creatorcontrib>Arguis, Pedro</creatorcontrib><creatorcontrib>Xaubet, Antoni</creatorcontrib><title>Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration</title><title>Archivos de bronconeumología (English ed.)</title><addtitle>Arch Bronconeumol</addtitle><description>To evaluate the clinical relevance of the presence of lymphocytes in transbronchial needle aspiration (TBNA) samples from pathological mediastinal lymph nodes in patients with suspected lung cancer.
Retrospective observational study evaluating the negative predictive value (NPV) of TBNA samples containing lymphocytes but not malignant cells.
A total of 266 TBNA were performed in 252 patients with pathological lymph nodes. One hundred and fifteen TBNA samples had evidence of malignant cells (43%), and 94 (35%) samples were considered as inadequate (absence of adequate cytological material or exclusive presence of bronchial epithelial cells). Out of the 57 TBNA samples remaining (21%), 15 could not be confirmed; in 32, TBNA samples were confirmed with alternative diagnostic techniques and in 10, they were confirmed after clinical and radiological follow-up. The NPV of the 32 samples that were confirmed with alternative diagnostic techniques was 84% decreasing down to 76% when the 10 TBNA samples confirmed after clinical and radiological follow-up were included.
The presence of lymphocytes in the TBNA sample does not exclude the neoplasic invasion of the specific lymph node analyzed.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - secondary</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy, Needle - methods</subject><subject>Bronchi</subject><subject>Bronchoscopy</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Carcinoma, Non-Small-Cell Lung - secondary</subject><subject>Carcinoma, Small Cell - diagnostic imaging</subject><subject>Carcinoma, Small Cell - secondary</subject><subject>Carcinoma, Squamous Cell - diagnostic imaging</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Colonic Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Mediastinum</subject><subject>Melanoma - diagnostic imaging</subject><subject>Melanoma - secondary</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Single-Blind Method</subject><subject>Skin Neoplasms - pathology</subject><issn>1579-2129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kLtOwzAUhi0kRMvlDRDKxpRgx46djqjiJlViAOboxDluXRw72OmQtycqZTr6b99wCLlltGCUyYd9AbGNmIqSHq2C0uqMLFmlVnnJytWCXKa0p1RKxtgFWcyeUlJWS_L9YbfeGqvBa8yCycYdZsOMwpN2Uz_sgp5GTJn1x3gWwYXtvHEZeHBTsuk4jeBTG4PXOztHHrFzmEEabITRBn9Nzg24hDene0W-np8-16_55v3lbf24yQcm6Jib2nRCStNqQZFrXQrQ2DHgnFZGCoUArRJtVwolaiaQco4KoNYMNYBR_Irc_3GHGH4OmMamt0mjc-AxHFJTz5CaKyrn5t2peWh77Joh2h7i1Pz_h_8CLhFq6g</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Lucena, Carmen M</creator><creator>Agustí, Carles</creator><creator>Martínez-Olondris, Pilar</creator><creator>Cano-Jiménez, Esteban</creator><creator>Marrades, Ramón M</creator><creator>Ramírez, Josep</creator><creator>Sánchez, Marcelo</creator><creator>Arguis, Pedro</creator><creator>Xaubet, Antoni</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration</title><author>Lucena, Carmen M ; Agustí, Carles ; Martínez-Olondris, Pilar ; Cano-Jiménez, Esteban ; Marrades, Ramón M ; Ramírez, Josep ; Sánchez, Marcelo ; Arguis, Pedro ; Xaubet, Antoni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-f8fd466fbc40e3cc24aced1a3305f647eaab74bd2474814e033e7aa8c1ecaaf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; spa</language><creationdate>2011</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - secondary</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy, Needle - methods</topic><topic>Bronchi</topic><topic>Bronchoscopy</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Carcinoma, Non-Small-Cell Lung - secondary</topic><topic>Carcinoma, Small Cell - diagnostic imaging</topic><topic>Carcinoma, Small Cell - secondary</topic><topic>Carcinoma, Squamous Cell - diagnostic imaging</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Colonic Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Mediastinum</topic><topic>Melanoma - diagnostic imaging</topic><topic>Melanoma - secondary</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Single-Blind Method</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucena, Carmen M</creatorcontrib><creatorcontrib>Agustí, Carles</creatorcontrib><creatorcontrib>Martínez-Olondris, Pilar</creatorcontrib><creatorcontrib>Cano-Jiménez, Esteban</creatorcontrib><creatorcontrib>Marrades, Ramón M</creatorcontrib><creatorcontrib>Ramírez, Josep</creatorcontrib><creatorcontrib>Sánchez, Marcelo</creatorcontrib><creatorcontrib>Arguis, Pedro</creatorcontrib><creatorcontrib>Xaubet, Antoni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Archivos de bronconeumología (English ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucena, Carmen M</au><au>Agustí, Carles</au><au>Martínez-Olondris, Pilar</au><au>Cano-Jiménez, Esteban</au><au>Marrades, Ramón M</au><au>Ramírez, Josep</au><au>Sánchez, Marcelo</au><au>Arguis, Pedro</au><au>Xaubet, Antoni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration</atitle><jtitle>Archivos de bronconeumología (English ed.)</jtitle><addtitle>Arch Bronconeumol</addtitle><date>2011-03</date><risdate>2011</risdate><volume>47</volume><issue>3</issue><spage>122</spage><epage>127</epage><pages>122-127</pages><eissn>1579-2129</eissn><abstract>To evaluate the clinical relevance of the presence of lymphocytes in transbronchial needle aspiration (TBNA) samples from pathological mediastinal lymph nodes in patients with suspected lung cancer.
Retrospective observational study evaluating the negative predictive value (NPV) of TBNA samples containing lymphocytes but not malignant cells.
A total of 266 TBNA were performed in 252 patients with pathological lymph nodes. One hundred and fifteen TBNA samples had evidence of malignant cells (43%), and 94 (35%) samples were considered as inadequate (absence of adequate cytological material or exclusive presence of bronchial epithelial cells). Out of the 57 TBNA samples remaining (21%), 15 could not be confirmed; in 32, TBNA samples were confirmed with alternative diagnostic techniques and in 10, they were confirmed after clinical and radiological follow-up. The NPV of the 32 samples that were confirmed with alternative diagnostic techniques was 84% decreasing down to 76% when the 10 TBNA samples confirmed after clinical and radiological follow-up were included.
The presence of lymphocytes in the TBNA sample does not exclude the neoplasic invasion of the specific lymph node analyzed.</abstract><cop>Spain</cop><pmid>21277665</pmid><doi>10.1016/j.arbres.2010.10.005</doi><tpages>6</tpages></addata></record> |
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| identifier | EISSN: 1579-2129 |
| ispartof | Archivos de bronconeumología (English ed.), 2011-03, Vol.47 (3), p.122-127 |
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| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - secondary Aged Aged, 80 and over Biopsy, Needle - methods Bronchi Bronchoscopy Carcinoma, Non-Small-Cell Lung - diagnostic imaging Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Small Cell - diagnostic imaging Carcinoma, Small Cell - secondary Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - secondary Colonic Neoplasms - pathology Female Humans Lung Neoplasms - diagnosis Lung Neoplasms - pathology Lymph Nodes - pathology Lymphatic Metastasis - diagnostic imaging Lymphatic Metastasis - pathology Lymphocyte Count Lymphocytes - pathology Male Mediastinum Melanoma - diagnostic imaging Melanoma - secondary Middle Aged Positron-Emission Tomography Predictive Value of Tests Retrospective Studies Single-Blind Method Skin Neoplasms - pathology |
| title | Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration |
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