Experimental Therapeutic Effects of Hybrid Liposomes on the Alzheimer's Disease in Vitro

Accumulation of β amyloid (Aβ) peptides to nerve cells should be associated with the onset of Alzheimer's disease (AD). We prepared hybrid liposomes (HL) composed of 90 mol% phospholipids having various charged head groups (cationic L-α-dimyristoyltrimethyl ammonium propane (DMTAP), anionic L-α...

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Veröffentlicht in:	YAKUGAKU ZASSHI 2011, Vol.131(5), pp.775-782
Hauptverfasser:	ZAKO, Keiko, SAKAGUCHI, Maki, KOMIZU, Yuji, ICHIHARA, Hideaki, GOTO, Koichi, MATSUMOTO, Yoko, UEOKA, Ryuichi
Format:	Artikel
Sprache:	jpn
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism amyloid β Anions Depression, Chemical Humans hybrid liposome Liposomes - pharmacology Liposomes - therapeutic use Neuroblastoma - metabolism Neuroblastoma - pathology Peptide Fragments - metabolism Tumor Cells, Cultured Unithiol - pharmacology Unithiol - therapeutic use
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