Influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs
The influence of two topical dexamethasone applications (dermal and ototopical) on plasma insulin, glucose, thyroid hormone and cortisol levels was investigated in beagle dogs. Both treatments significantly decreased basal cortisol values, associated with exaggerated rise in insulin (∼50%), together...
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| Veröffentlicht in: | Research in veterinary science 2011-06, Vol.90 (3), p.491-497 |
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| creator | Gottschalk, J. Einspanier, A. Ungemach, F.R. Abraham, G. |
| description | The influence of two topical dexamethasone applications (dermal and ototopical) on plasma insulin, glucose, thyroid hormone and cortisol levels was investigated in beagle dogs. Both treatments significantly decreased basal cortisol values, associated with exaggerated rise in insulin (∼50%), together with unchanged serum glucose levels. Dermal dexamethasone quickly decreased plasma thyroxin (T
4) levels; whereas dexamethasone in ear drops gradually inhibited time-dependently T
4 release (18–50%). Both formulations blunted plasma triiodothyronine (T
3) levels but the response induced by dermal dexamethasone was stronger than by dexamethasone ear drops. Upon drug withdrawal, insulin secretion returned to baseline a week after treatment cessation, while cortisol, T
4 and T
3 levels did not reach baseline values. These results suggest that topical glucocorticoids unexpectedly trigger secondary hypothyroidism with concomitant suppression of hypothalamic–pituitary–adrenal axis but sensitize the endocrine pancreas, thus, their application needs careful evaluation for surprisingly different effects on endocrine stress axis activity. |
| doi_str_mv | 10.1016/j.rvsc.2010.06.026 |
| format | Article |
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4) levels; whereas dexamethasone in ear drops gradually inhibited time-dependently T
4 release (18–50%). Both formulations blunted plasma triiodothyronine (T
3) levels but the response induced by dermal dexamethasone was stronger than by dexamethasone ear drops. Upon drug withdrawal, insulin secretion returned to baseline a week after treatment cessation, while cortisol, T
4 and T
3 levels did not reach baseline values. These results suggest that topical glucocorticoids unexpectedly trigger secondary hypothyroidism with concomitant suppression of hypothalamic–pituitary–adrenal axis but sensitize the endocrine pancreas, thus, their application needs careful evaluation for surprisingly different effects on endocrine stress axis activity.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2010.06.026</identifier><identifier>PMID: 20667567</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Administration, Topical ; Animals ; Beagle ; blood glucose ; Blood Glucose - analysis ; Blood Glucose - drug effects ; Cortisol ; dexamethasone ; Dexamethasone - administration & dosage ; Dexamethasone - pharmacology ; Dogs ; Dogs - blood ; ears ; Glucocorticoids - administration & dosage ; Glucocorticoids - pharmacology ; Glucose ; Hormones ; Hydrocortisone - blood ; Hypothalamic–pituitary–adrenal (HPA) axis ; Hypothalamic–pituitary–thyroid (HPT) axis ; hypothyroidism ; Insulin ; Insulin - blood ; insulin secretion ; Male ; normal values ; pancreas ; Rodents ; Thyroid gland ; Thyroid hormones ; Thyroid Hormones - blood ; topical application ; Topical glucocorticoids ; triiodothyronine ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2011-06, Vol.90 (3), p.491-497</ispartof><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-1e291750d81e924809dd5cfc0e30de2311130c8344d749ea3b70d19d7d110cac3</citedby><cites>FETCH-LOGICAL-c407t-1e291750d81e924809dd5cfc0e30de2311130c8344d749ea3b70d19d7d110cac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S003452881000233X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20667567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gottschalk, J.</creatorcontrib><creatorcontrib>Einspanier, A.</creatorcontrib><creatorcontrib>Ungemach, F.R.</creatorcontrib><creatorcontrib>Abraham, G.</creatorcontrib><title>Influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The influence of two topical dexamethasone applications (dermal and ototopical) on plasma insulin, glucose, thyroid hormone and cortisol levels was investigated in beagle dogs. Both treatments significantly decreased basal cortisol values, associated with exaggerated rise in insulin (∼50%), together with unchanged serum glucose levels. Dermal dexamethasone quickly decreased plasma thyroxin (T
4) levels; whereas dexamethasone in ear drops gradually inhibited time-dependently T
4 release (18–50%). Both formulations blunted plasma triiodothyronine (T
3) levels but the response induced by dermal dexamethasone was stronger than by dexamethasone ear drops. Upon drug withdrawal, insulin secretion returned to baseline a week after treatment cessation, while cortisol, T
4 and T
3 levels did not reach baseline values. These results suggest that topical glucocorticoids unexpectedly trigger secondary hypothyroidism with concomitant suppression of hypothalamic–pituitary–adrenal axis but sensitize the endocrine pancreas, thus, their application needs careful evaluation for surprisingly different effects on endocrine stress axis activity.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Beagle</subject><subject>blood glucose</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - drug effects</subject><subject>Cortisol</subject><subject>dexamethasone</subject><subject>Dexamethasone - administration & dosage</subject><subject>Dexamethasone - pharmacology</subject><subject>Dogs</subject><subject>Dogs - blood</subject><subject>ears</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - pharmacology</subject><subject>Glucose</subject><subject>Hormones</subject><subject>Hydrocortisone - blood</subject><subject>Hypothalamic–pituitary–adrenal (HPA) axis</subject><subject>Hypothalamic–pituitary–thyroid (HPT) axis</subject><subject>hypothyroidism</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>insulin secretion</subject><subject>Male</subject><subject>normal values</subject><subject>pancreas</subject><subject>Rodents</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid Hormones - blood</subject><subject>topical application</subject><subject>Topical glucocorticoids</subject><subject>triiodothyronine</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7jj6BzxowIOXnbHy0Uk3eJHFj4UFD7rnkE2qZzKkO23SPbj_3oyzevDgKVA875uiHkJeMtgyYOrdYZuPxW051AGoLXD1iKxYI_iGK8UekxWAkJuGt-0FeVbKAQAkY_opueCglG6UXpHpeuzjgqNDmno6pyk4G6nHn3bAeW9LGpHaaYp1PIc0FppGGsayxDBe0l1cXCp4Sef9fU7B033Kw-_E6KlLeQ4lRRrxiLHUFPVpV56TJ72NBV88vGty--nj96svm5uvn6-vPtxsnAQ9bxjyjukGfMuw47KFzvvG9Q5QgEcuGGMCXCuk9Fp2aMWdBs86rz1j4KwTa_L23Dvl9GPBMpshFIcx2hHTUkyrpG4FE7qSb_4hD2nJY13OMBANSBCKVYqfKZdTKRl7M-Uw2HxfIXPSYQ7mpMOcdBhQpuqooVcP1cvdgP5v5M_9K_D6DPQ2GbvLoZjbb7VBArCmk_X_NXl_JuoN8Rgwm-LCyZcPGd1sfAr_2-AXy8ClWQ</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Gottschalk, J.</creator><creator>Einspanier, A.</creator><creator>Ungemach, F.R.</creator><creator>Abraham, G.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs</title><author>Gottschalk, J. ; Einspanier, A. ; Ungemach, F.R. ; Abraham, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-1e291750d81e924809dd5cfc0e30de2311130c8344d749ea3b70d19d7d110cac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Beagle</topic><topic>blood glucose</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose - drug effects</topic><topic>Cortisol</topic><topic>dexamethasone</topic><topic>Dexamethasone - administration & dosage</topic><topic>Dexamethasone - pharmacology</topic><topic>Dogs</topic><topic>Dogs - blood</topic><topic>ears</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - pharmacology</topic><topic>Glucose</topic><topic>Hormones</topic><topic>Hydrocortisone - blood</topic><topic>Hypothalamic–pituitary–adrenal (HPA) axis</topic><topic>Hypothalamic–pituitary–thyroid (HPT) axis</topic><topic>hypothyroidism</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>insulin secretion</topic><topic>Male</topic><topic>normal values</topic><topic>pancreas</topic><topic>Rodents</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid Hormones - blood</topic><topic>topical application</topic><topic>Topical glucocorticoids</topic><topic>triiodothyronine</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gottschalk, J.</creatorcontrib><creatorcontrib>Einspanier, A.</creatorcontrib><creatorcontrib>Ungemach, F.R.</creatorcontrib><creatorcontrib>Abraham, G.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gottschalk, J.</au><au>Einspanier, A.</au><au>Ungemach, F.R.</au><au>Abraham, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>90</volume><issue>3</issue><spage>491</spage><epage>497</epage><pages>491-497</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The influence of two topical dexamethasone applications (dermal and ototopical) on plasma insulin, glucose, thyroid hormone and cortisol levels was investigated in beagle dogs. Both treatments significantly decreased basal cortisol values, associated with exaggerated rise in insulin (∼50%), together with unchanged serum glucose levels. Dermal dexamethasone quickly decreased plasma thyroxin (T
4) levels; whereas dexamethasone in ear drops gradually inhibited time-dependently T
4 release (18–50%). Both formulations blunted plasma triiodothyronine (T
3) levels but the response induced by dermal dexamethasone was stronger than by dexamethasone ear drops. Upon drug withdrawal, insulin secretion returned to baseline a week after treatment cessation, while cortisol, T
4 and T
3 levels did not reach baseline values. These results suggest that topical glucocorticoids unexpectedly trigger secondary hypothyroidism with concomitant suppression of hypothalamic–pituitary–adrenal axis but sensitize the endocrine pancreas, thus, their application needs careful evaluation for surprisingly different effects on endocrine stress axis activity.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>20667567</pmid><doi>10.1016/j.rvsc.2010.06.026</doi><tpages>7</tpages></addata></record> |
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| subjects | Administration, Topical Animals Beagle blood glucose Blood Glucose - analysis Blood Glucose - drug effects Cortisol dexamethasone Dexamethasone - administration & dosage Dexamethasone - pharmacology Dogs Dogs - blood ears Glucocorticoids - administration & dosage Glucocorticoids - pharmacology Glucose Hormones Hydrocortisone - blood Hypothalamic–pituitary–adrenal (HPA) axis Hypothalamic–pituitary–thyroid (HPT) axis hypothyroidism Insulin Insulin - blood insulin secretion Male normal values pancreas Rodents Thyroid gland Thyroid hormones Thyroid Hormones - blood topical application Topical glucocorticoids triiodothyronine Veterinary medicine |
| title | Influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs |
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