The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury
The incidence and prevalence of diabetes have recently increased. Hyperglycemia, which is commonly seen in intensive care medicine, is associated with increased morbidity and mortality. For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB...
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| Veröffentlicht in: | The Journal of surgical research 2011-06, Vol.168 (1), p.111-118 |
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| container_title | The Journal of surgical research |
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| creator | Hagiwara, Satoshi, M.D., Ph.D Iwasaka, Hideo, M.D., Ph.D Shingu, Chihiro, M.D Matumoto, Shigekiyo, M.D Hasegawa, Akira, M.D Noguchi, Takayuki, M.D., Ph.D |
| description | The incidence and prevalence of diabetes have recently increased. Hyperglycemia, which is commonly seen in intensive care medicine, is associated with increased morbidity and mortality. For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases. This study investigated the increase in lung damage due to diabetes and the rise in HMGB1 levels in a lipopolysaccharide (LPS)-induced systemic inflammation rat model. Diabetes was induced by streptozotocin infusion 4 wk prior to LPS administration, followed by measurements of blood glucose and serum cytokine levels. Separate cohorts were sacrificed 12h post-LPS administration and analyzed for lung damage. Diabetic animals had significantly higher blood glucose and enhanced lung damage. In addition, levels of serum HMGB1, tumor necrosis factor-α, and interleukin-6 were increased in diabetic rats. Diabetes may exacerbate systemic inflammation as evidenced by higher serum HMGB1 and cytokine levels and enhanced lung damage in the rat systemic inflammation model. |
| doi_str_mv | 10.1016/j.jss.2009.07.039 |
| format | Article |
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Hyperglycemia, which is commonly seen in intensive care medicine, is associated with increased morbidity and mortality. For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases. This study investigated the increase in lung damage due to diabetes and the rise in HMGB1 levels in a lipopolysaccharide (LPS)-induced systemic inflammation rat model. Diabetes was induced by streptozotocin infusion 4 wk prior to LPS administration, followed by measurements of blood glucose and serum cytokine levels. Separate cohorts were sacrificed 12h post-LPS administration and analyzed for lung damage. Diabetic animals had significantly higher blood glucose and enhanced lung damage. In addition, levels of serum HMGB1, tumor necrosis factor-α, and interleukin-6 were increased in diabetic rats. Diabetes may exacerbate systemic inflammation as evidenced by higher serum HMGB1 and cytokine levels and enhanced lung damage in the rat systemic inflammation model.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2009.07.039</identifier><identifier>PMID: 19959191</identifier><identifier>CODEN: JSGRA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Lung Injury - blood ; Acute Lung Injury - chemically induced ; Acute Lung Injury - epidemiology ; Animals ; Biological and medical sciences ; Comorbidity ; cytokine ; diabetes ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - epidemiology ; Diabetes. Impaired glucose tolerance ; Disease Models, Animal ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endotoxins - adverse effects ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; General aspects ; high mobility group box 1 (HMGB1) protein ; HMGB1 Protein - blood ; inflammation ; Insulin - blood ; Interleukin-6 - blood ; lipopolysaccharide ; lung injury ; Male ; Medical sciences ; Rats ; Rats, Wistar ; Streptozocin - adverse effects ; Surgery ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>The Journal of surgical research, 2011-06, Vol.168 (1), p.111-118</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. 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Hyperglycemia, which is commonly seen in intensive care medicine, is associated with increased morbidity and mortality. For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases. This study investigated the increase in lung damage due to diabetes and the rise in HMGB1 levels in a lipopolysaccharide (LPS)-induced systemic inflammation rat model. Diabetes was induced by streptozotocin infusion 4 wk prior to LPS administration, followed by measurements of blood glucose and serum cytokine levels. Separate cohorts were sacrificed 12h post-LPS administration and analyzed for lung damage. Diabetic animals had significantly higher blood glucose and enhanced lung damage. In addition, levels of serum HMGB1, tumor necrosis factor-α, and interleukin-6 were increased in diabetic rats. Diabetes may exacerbate systemic inflammation as evidenced by higher serum HMGB1 and cytokine levels and enhanced lung damage in the rat systemic inflammation model.</description><subject>Acute Lung Injury - blood</subject><subject>Acute Lung Injury - chemically induced</subject><subject>Acute Lung Injury - epidemiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Comorbidity</subject><subject>cytokine</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - epidemiology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Disease Models, Animal</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endotoxins - adverse effects</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>General aspects</subject><subject>high mobility group box 1 (HMGB1) protein</subject><subject>HMGB1 Protein - blood</subject><subject>inflammation</subject><subject>Insulin - blood</subject><subject>Interleukin-6 - blood</subject><subject>lipopolysaccharide</subject><subject>lung injury</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptozocin - adverse effects</subject><subject>Surgery</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkGL1DAUx4so7uzqB_AiuYinji9p2jQIwrqOuwMjCq7n0Cavu6mdZDZpZWY_vSkzKHjwkpDw-78XfnlZ9orCkgKt3vXLPsYlA5BLEEso5JNsQUGWeV2J4mm2AGAs5zXws-w8xh7SWYrieXZGpSwllXSRPd7eI1l1HeqR-I6s9jsMdotubAbyyTYtjhiJd-TG3t2TL761gx0P5Dr4aUc--j2h5FvwI1o3RwPGaBM8n5zxo99bl6-dmTQacqmnEclmcndk7fopHF5kz7pmiPjytF9kPz6vbq9u8s3X6_XV5SbXJRRjzniNLWitpewMlMyYNt13puQda-sWQMimhqoSUFHOC9aazpiiZDUwXXEui4vs7bHuLviHCeOotjZqHIbGoZ-iqisu6oKyKpH0SOrgYwzYqV2S0YSDoqBm46pXybiajSsQKhlPmden6lO7RfM3cVKcgDcnoIm6GbrQOG3jH45xypkQc_P3Rw6Ti18Wg4raokvqbEi_o4y3_33Gh3_SerDOpoY_8YCx91NwSbKiKjIF6vs8GvNkgIS0CFH8BnZNss4</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Hagiwara, Satoshi, M.D., Ph.D</creator><creator>Iwasaka, Hideo, M.D., Ph.D</creator><creator>Shingu, Chihiro, M.D</creator><creator>Matumoto, Shigekiyo, M.D</creator><creator>Hasegawa, Akira, M.D</creator><creator>Noguchi, Takayuki, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury</title><author>Hagiwara, Satoshi, M.D., Ph.D ; Iwasaka, Hideo, M.D., Ph.D ; Shingu, Chihiro, M.D ; Matumoto, Shigekiyo, M.D ; Hasegawa, Akira, M.D ; Noguchi, Takayuki, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-248eb0ccc99fd052ddb503fd54f2b8b0079a806670614432bdfdd352802c64493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute Lung Injury - blood</topic><topic>Acute Lung Injury - chemically induced</topic><topic>Acute Lung Injury - epidemiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Comorbidity</topic><topic>cytokine</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - epidemiology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Disease Models, Animal</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Endotoxins - adverse effects</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>General aspects</topic><topic>high mobility group box 1 (HMGB1) protein</topic><topic>HMGB1 Protein - blood</topic><topic>inflammation</topic><topic>Insulin - blood</topic><topic>Interleukin-6 - blood</topic><topic>lipopolysaccharide</topic><topic>lung injury</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptozocin - adverse effects</topic><topic>Surgery</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hagiwara, Satoshi, M.D., Ph.D</creatorcontrib><creatorcontrib>Iwasaka, Hideo, M.D., Ph.D</creatorcontrib><creatorcontrib>Shingu, Chihiro, M.D</creatorcontrib><creatorcontrib>Matumoto, Shigekiyo, M.D</creatorcontrib><creatorcontrib>Hasegawa, Akira, M.D</creatorcontrib><creatorcontrib>Noguchi, Takayuki, M.D., Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagiwara, Satoshi, M.D., Ph.D</au><au>Iwasaka, Hideo, M.D., Ph.D</au><au>Shingu, Chihiro, M.D</au><au>Matumoto, Shigekiyo, M.D</au><au>Hasegawa, Akira, M.D</au><au>Noguchi, Takayuki, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>168</volume><issue>1</issue><spage>111</spage><epage>118</epage><pages>111-118</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><coden>JSGRA2</coden><abstract>The incidence and prevalence of diabetes have recently increased. Hyperglycemia, which is commonly seen in intensive care medicine, is associated with increased morbidity and mortality. For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases. This study investigated the increase in lung damage due to diabetes and the rise in HMGB1 levels in a lipopolysaccharide (LPS)-induced systemic inflammation rat model. Diabetes was induced by streptozotocin infusion 4 wk prior to LPS administration, followed by measurements of blood glucose and serum cytokine levels. Separate cohorts were sacrificed 12h post-LPS administration and analyzed for lung damage. Diabetic animals had significantly higher blood glucose and enhanced lung damage. In addition, levels of serum HMGB1, tumor necrosis factor-α, and interleukin-6 were increased in diabetic rats. Diabetes may exacerbate systemic inflammation as evidenced by higher serum HMGB1 and cytokine levels and enhanced lung damage in the rat systemic inflammation model.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19959191</pmid><doi>10.1016/j.jss.2009.07.039</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute Lung Injury - blood Acute Lung Injury - chemically induced Acute Lung Injury - epidemiology Animals Biological and medical sciences Comorbidity cytokine diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - epidemiology Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endotoxins - adverse effects Etiopathogenesis. Screening. Investigations. Target tissue resistance General aspects high mobility group box 1 (HMGB1) protein HMGB1 Protein - blood inflammation Insulin - blood Interleukin-6 - blood lipopolysaccharide lung injury Male Medical sciences Rats Rats, Wistar Streptozocin - adverse effects Surgery Tumor Necrosis Factor-alpha - blood |
| title | The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury |
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