Activated Protein C and Normal Saline Infusion Might Prevent Deleterious Effects of Remote Acute Lung Injury Caused by Intestinal Ischemia-Reperfusion: An Experimental Study in the Rat Model

Background Intestinal ischemia-reperfusion is a common medical event associated with both clinical and experimental distant organ injury. In particular, the lung tissue appears to be susceptible to injury resulting from systemic inflammatory mediator activation. Drotrecogin α (activated) or recombin...

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Veröffentlicht in:	The Journal of surgical research 2011-06, Vol.168 (1), p.e81-e86
Hauptverfasser:	Tarhan, Omer Ridvan, M.D, Ceylan, Berit Gokce, M.D, Kapucuoglu, Nilgun, M.D, Sutcu, Recep, M.D, Kumbul, Kadir, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	activated protein C acute lung injury Acute Lung Injury - etiology Acute Lung Injury - metabolism Acute Lung Injury - prevention & control Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Dose-Response Relationship, Drug Glutathione Peroxidase - metabolism glutathione peroxidase activity Infusions, Intravenous intestinal ischemia-reperfusion Intestines - blood supply lung edema lung polymorphonuclear leukocyte sequestration Male malondialdehyde Malondialdehyde - metabolism Models, Animal myeloperoxidase activity Neutrophils - pathology normal saline Peroxidase - metabolism Protein C - administration & dosage Protein C - therapeutic use Rats Rats, Wistar Reperfusion Injury - complications Sodium Chloride - administration & dosage Sodium Chloride - therapeutic use Surgery Treatment Outcome
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