Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study
Postmortem and genetic studies have clearly demonstrated changes in GABA(B) receptors in neuropsychiatric disorders such as autism, bipolar disorder, major depression, and schizophrenia. Moreover, a number of recent studies have stressed the importance of cerebellar dysfunction in these same disorde...
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| Veröffentlicht in: | Schizophrenia research 2011-05, Vol.128 (1-3), p.37-43 |
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| container_title | Schizophrenia research |
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| creator | Fatemi, S Hossein Folsom, Timothy D Thuras, Paul D |
| description | Postmortem and genetic studies have clearly demonstrated changes in GABA(B) receptors in neuropsychiatric disorders such as autism, bipolar disorder, major depression, and schizophrenia. Moreover, a number of recent studies have stressed the importance of cerebellar dysfunction in these same disorders. In the current study, we examined protein levels of the two GABA(B) receptor subunits GABBR1 and GABBR2 in lateral cerebella from a well-characterized cohort of subjects with schizophrenia (n=15), bipolar disorder (n=14), major depression (n=13) and healthy controls (n=12). We found significant reductions in protein for both GABBR1 and GABBR2 in lateral cerebella from subjects with schizophrenia, bipolar disorder and major depression when compared with controls. These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention. |
| doi_str_mv | 10.1016/j.schres.2010.12.025 |
| format | Article |
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These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention.</description><subject>Actins - metabolism</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Brain - metabolism</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mood Disorders - metabolism</subject><subject>Mood Disorders - pathology</subject><subject>Phosphopyruvate Hydratase - metabolism</subject><subject>Postmortem Changes</subject><subject>Receptors, GABA-B - deficiency</subject><subject>Schizophrenia - metabolism</subject><subject>Schizophrenia - pathology</subject><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDFPwzAQhS0kREvhHyDkDRgSznYSt2xtgYJUiQUmhsixHeGqiYPPGcKvJxVl-qS7996dHiFXDFIGrLjfpai_gsWUw2HEU-D5CZmyXIqE57CYkHPEHQCwHOQZmXAmQEjBpuTz0dZOu4jUtXSzXC1vV3c0WG276APFAaNtDqsx3_34bjzSOkVVa2jjvaHGoQ_GBnyginYeY-PDwYGxN8MFOa3VHu3lkTPy8fz0vn5Jtm-b1_Vym3Qsg5gwXoHiutYLY9iCFZUQmalkoStlpVSy0nL8Vxcqh7qupdIjisxoC1yrLBdiRm7-crvgv3uLsWwcarvfq9b6Hst5kck5l3k2Kq-Pyr5qrCm74BoVhvK_D_ELPVZjQQ</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Fatemi, S Hossein</creator><creator>Folsom, Timothy D</creator><creator>Thuras, Paul D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201105</creationdate><title>Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study</title><author>Fatemi, S Hossein ; Folsom, Timothy D ; Thuras, Paul D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-12b0a2cfc9dd1916b334db76cbae77a7bc7213c6a50fff7ac0ff64dce02ca4533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Actins - metabolism</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Brain - metabolism</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mood Disorders - metabolism</topic><topic>Mood Disorders - pathology</topic><topic>Phosphopyruvate Hydratase - metabolism</topic><topic>Postmortem Changes</topic><topic>Receptors, GABA-B - deficiency</topic><topic>Schizophrenia - metabolism</topic><topic>Schizophrenia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fatemi, S Hossein</creatorcontrib><creatorcontrib>Folsom, Timothy D</creatorcontrib><creatorcontrib>Thuras, Paul D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fatemi, S Hossein</au><au>Folsom, Timothy D</au><au>Thuras, Paul D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2011-05</date><risdate>2011</risdate><volume>128</volume><issue>1-3</issue><spage>37</spage><epage>43</epage><pages>37-43</pages><eissn>1573-2509</eissn><abstract>Postmortem and genetic studies have clearly demonstrated changes in GABA(B) receptors in neuropsychiatric disorders such as autism, bipolar disorder, major depression, and schizophrenia. 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| fulltext | fulltext |
| identifier | EISSN: 1573-2509 |
| ispartof | Schizophrenia research, 2011-05, Vol.128 (1-3), p.37-43 |
| issn | 1573-2509 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_864782754 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Actins - metabolism Adult Analysis of Variance Brain - metabolism Chi-Square Distribution Female Humans Male Middle Aged Mood Disorders - metabolism Mood Disorders - pathology Phosphopyruvate Hydratase - metabolism Postmortem Changes Receptors, GABA-B - deficiency Schizophrenia - metabolism Schizophrenia - pathology |
| title | Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study |
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