Enhanced immune response of T-cell independent or dependent antigens in SIGN-R1 knock-out mice
Dextran was used to explore a novel method of enhancing an immune response against T-cell independent type 2 (TI-2) polysaccharide antigens, because of its suitability as a model for the immunogenecity of many TI-2 polysaccharide antigens and its high affinity to SIGN-R1. Here we showed that the pri...
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| Veröffentlicht in: | Hybridoma (2005) 2011-04, Vol.30 (2), p.109-116 |
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| container_title | Hybridoma (2005) |
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| creator | Choi, Hyeong-Jwa Choi, Woo-Sung Park, Jin-Yeon Kang, Kyeong-Hyeon Prabagar, Miglena G Shin, Chan Young Kang, Young-Sun |
| description | Dextran was used to explore a novel method of enhancing an immune response against T-cell independent type 2 (TI-2) polysaccharide antigens, because of its suitability as a model for the immunogenecity of many TI-2 polysaccharide antigens and its high affinity to SIGN-R1. Here we showed that the primary immune response of IgM, IgG3, and IgG2b was enhanced by dextran in SIGN-R1 knock-out (KO) mice, further evoking the induction of a secondary immune response to IgG2b in parallel. On the other hand, an immune response of IgG1 and IgG2b against T-cell dependent (TD) antigen was strongly enhanced by the administration of ovalbumin (OVA) in SIGN-R1 KO mice. These results indicate that SIGN-R1 is critical in the regulation of immune responses. Therefore, our study suggests that inhibition of TI-2 polysaccharide antigen uptake in SIGN-R1(+) macrophages contributes to the development of novel vaccination strategies against TI-2 polysaccharide antigens. |
| doi_str_mv | 10.1089/hyb.2010.0093 |
| format | Article |
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Here we showed that the primary immune response of IgM, IgG3, and IgG2b was enhanced by dextran in SIGN-R1 knock-out (KO) mice, further evoking the induction of a secondary immune response to IgG2b in parallel. On the other hand, an immune response of IgG1 and IgG2b against T-cell dependent (TD) antigen was strongly enhanced by the administration of ovalbumin (OVA) in SIGN-R1 KO mice. These results indicate that SIGN-R1 is critical in the regulation of immune responses. Therefore, our study suggests that inhibition of TI-2 polysaccharide antigen uptake in SIGN-R1(+) macrophages contributes to the development of novel vaccination strategies against TI-2 polysaccharide antigens.</description><identifier>ISSN: 1554-0014</identifier><identifier>EISSN: 1557-8348</identifier><identifier>DOI: 10.1089/hyb.2010.0093</identifier><identifier>PMID: 21529282</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Antigens ; Antigens, T-Independent - immunology ; Bacterial Infections - prevention & control ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - immunology ; Cell Adhesion Molecules - metabolism ; Dextran ; Dextrans - immunology ; Dextrans - pharmacology ; Female ; Fluorescein-5-isothiocyanate - analogs & derivatives ; Fluorescein-5-isothiocyanate - pharmacology ; Health aspects ; Immune response ; Immunity, Humoral - drug effects ; Immunoglobulin G ; Immunoglobulin G - analysis ; Immunoglobulin G - immunology ; Immunoglobulin M ; Immunoglobulin M - analysis ; Immunoglobulin M - immunology ; Lectins, C-Type - genetics ; Lectins, C-Type - immunology ; Lectins, C-Type - metabolism ; Liver - immunology ; Lymphocytes T ; Macrophages ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Ovalbumin ; Ovalbumin - immunology ; Ovalbumin - pharmacology ; Physiological aspects ; Polysaccharides ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - immunology ; Receptors, Cell Surface - metabolism ; Receptors, Immunologic - genetics ; Receptors, Immunologic - immunology ; Receptors, Immunologic - metabolism ; Spleen - immunology ; T cells ; T-Lymphocytes - immunology ; Vaccination ; Vaccination - methods</subject><ispartof>Hybridoma (2005), 2011-04, Vol.30 (2), p.109-116</ispartof><rights>COPYRIGHT 2011 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-3c1b8dda7d9556066389db6dbfbdc172074e52145377fa4301d49049d8dbe1643</citedby><cites>FETCH-LOGICAL-c392t-3c1b8dda7d9556066389db6dbfbdc172074e52145377fa4301d49049d8dbe1643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21529282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Hyeong-Jwa</creatorcontrib><creatorcontrib>Choi, Woo-Sung</creatorcontrib><creatorcontrib>Park, Jin-Yeon</creatorcontrib><creatorcontrib>Kang, Kyeong-Hyeon</creatorcontrib><creatorcontrib>Prabagar, Miglena G</creatorcontrib><creatorcontrib>Shin, Chan Young</creatorcontrib><creatorcontrib>Kang, Young-Sun</creatorcontrib><title>Enhanced immune response of T-cell independent or dependent antigens in SIGN-R1 knock-out mice</title><title>Hybridoma (2005)</title><addtitle>Hybridoma (Larchmt)</addtitle><description>Dextran was used to explore a novel method of enhancing an immune response against T-cell independent type 2 (TI-2) polysaccharide antigens, because of its suitability as a model for the immunogenecity of many TI-2 polysaccharide antigens and its high affinity to SIGN-R1. Here we showed that the primary immune response of IgM, IgG3, and IgG2b was enhanced by dextran in SIGN-R1 knock-out (KO) mice, further evoking the induction of a secondary immune response to IgG2b in parallel. On the other hand, an immune response of IgG1 and IgG2b against T-cell dependent (TD) antigen was strongly enhanced by the administration of ovalbumin (OVA) in SIGN-R1 KO mice. These results indicate that SIGN-R1 is critical in the regulation of immune responses. Therefore, our study suggests that inhibition of TI-2 polysaccharide antigen uptake in SIGN-R1(+) macrophages contributes to the development of novel vaccination strategies against TI-2 polysaccharide antigens.</description><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, T-Independent - immunology</subject><subject>Bacterial Infections - prevention & control</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - immunology</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Dextran</subject><subject>Dextrans - immunology</subject><subject>Dextrans - pharmacology</subject><subject>Female</subject><subject>Fluorescein-5-isothiocyanate - analogs & derivatives</subject><subject>Fluorescein-5-isothiocyanate - pharmacology</subject><subject>Health aspects</subject><subject>Immune response</subject><subject>Immunity, Humoral - drug effects</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M</subject><subject>Immunoglobulin M - analysis</subject><subject>Immunoglobulin M - immunology</subject><subject>Lectins, C-Type - genetics</subject><subject>Lectins, C-Type - immunology</subject><subject>Lectins, C-Type - metabolism</subject><subject>Liver - immunology</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Ovalbumin</subject><subject>Ovalbumin - immunology</subject><subject>Ovalbumin - pharmacology</subject><subject>Physiological aspects</subject><subject>Polysaccharides</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - immunology</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Immunologic - genetics</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Spleen - immunology</subject><subject>T cells</subject><subject>T-Lymphocytes - immunology</subject><subject>Vaccination</subject><subject>Vaccination - methods</subject><issn>1554-0014</issn><issn>1557-8348</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9LHDEUx0OpVN322KsEerCXbPN7MkdZrAqiYO21IZO80dGdZDuZOfjfm3G1IkgJJHnh8x5f8kHoK6NLRk394_ahWXJaKkpr8QHtMaUqYoQ0H5_uklDK5C7az_mOUqENrz6hXc4Ur7nhe-jPcbx10UPAXd9PEfAAeZNiBpxafE08rNe4iwE2ULY44jTg18LFsbuBmAuBf52dXJArhu9j8vckTSPuOw-f0U7r1hm-PJ8L9Pvn8fXqlJxfnpytjs6JFzUfifCsMSG4KtRKaaq1MHVodGjaJnhWcVpJUJxJJaqqdVJQFmRNZR1MaIBpKRbocDt3M6S_E-TR9l2ew7sIacrWaFkZKrkp5Pf_kkxwYRgVah76bYveuDXYLrZpHJyfcXvElRZamZJogZbvUGUFKD-QIrRdeX_TQLYNfkg5D9DazdD1bniwjNrZqS1O7ezUzk4Lf_CceGp6CP_oF4niEbLrmbI</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Choi, Hyeong-Jwa</creator><creator>Choi, Woo-Sung</creator><creator>Park, Jin-Yeon</creator><creator>Kang, Kyeong-Hyeon</creator><creator>Prabagar, Miglena G</creator><creator>Shin, Chan Young</creator><creator>Kang, Young-Sun</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Enhanced immune response of T-cell independent or dependent antigens in SIGN-R1 knock-out mice</title><author>Choi, Hyeong-Jwa ; Choi, Woo-Sung ; Park, Jin-Yeon ; Kang, Kyeong-Hyeon ; Prabagar, Miglena G ; Shin, Chan Young ; Kang, Young-Sun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-3c1b8dda7d9556066389db6dbfbdc172074e52145377fa4301d49049d8dbe1643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, T-Independent - immunology</topic><topic>Bacterial Infections - prevention & control</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - immunology</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Dextran</topic><topic>Dextrans - immunology</topic><topic>Dextrans - pharmacology</topic><topic>Female</topic><topic>Fluorescein-5-isothiocyanate - analogs & derivatives</topic><topic>Fluorescein-5-isothiocyanate - pharmacology</topic><topic>Health aspects</topic><topic>Immune response</topic><topic>Immunity, Humoral - drug effects</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M</topic><topic>Immunoglobulin M - analysis</topic><topic>Immunoglobulin M - immunology</topic><topic>Lectins, C-Type - genetics</topic><topic>Lectins, C-Type - immunology</topic><topic>Lectins, C-Type - metabolism</topic><topic>Liver - immunology</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Ovalbumin</topic><topic>Ovalbumin - immunology</topic><topic>Ovalbumin - pharmacology</topic><topic>Physiological aspects</topic><topic>Polysaccharides</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - immunology</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Immunologic - genetics</topic><topic>Receptors, Immunologic - immunology</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Spleen - immunology</topic><topic>T cells</topic><topic>T-Lymphocytes - immunology</topic><topic>Vaccination</topic><topic>Vaccination - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Hyeong-Jwa</creatorcontrib><creatorcontrib>Choi, Woo-Sung</creatorcontrib><creatorcontrib>Park, Jin-Yeon</creatorcontrib><creatorcontrib>Kang, Kyeong-Hyeon</creatorcontrib><creatorcontrib>Prabagar, Miglena G</creatorcontrib><creatorcontrib>Shin, Chan Young</creatorcontrib><creatorcontrib>Kang, Young-Sun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hybridoma (2005)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Hyeong-Jwa</au><au>Choi, Woo-Sung</au><au>Park, Jin-Yeon</au><au>Kang, Kyeong-Hyeon</au><au>Prabagar, Miglena G</au><au>Shin, Chan Young</au><au>Kang, Young-Sun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced immune response of T-cell independent or dependent antigens in SIGN-R1 knock-out mice</atitle><jtitle>Hybridoma (2005)</jtitle><addtitle>Hybridoma (Larchmt)</addtitle><date>2011-04</date><risdate>2011</risdate><volume>30</volume><issue>2</issue><spage>109</spage><epage>116</epage><pages>109-116</pages><issn>1554-0014</issn><eissn>1557-8348</eissn><abstract>Dextran was used to explore a novel method of enhancing an immune response against T-cell independent type 2 (TI-2) polysaccharide antigens, because of its suitability as a model for the immunogenecity of many TI-2 polysaccharide antigens and its high affinity to SIGN-R1. Here we showed that the primary immune response of IgM, IgG3, and IgG2b was enhanced by dextran in SIGN-R1 knock-out (KO) mice, further evoking the induction of a secondary immune response to IgG2b in parallel. On the other hand, an immune response of IgG1 and IgG2b against T-cell dependent (TD) antigen was strongly enhanced by the administration of ovalbumin (OVA) in SIGN-R1 KO mice. These results indicate that SIGN-R1 is critical in the regulation of immune responses. Therefore, our study suggests that inhibition of TI-2 polysaccharide antigen uptake in SIGN-R1(+) macrophages contributes to the development of novel vaccination strategies against TI-2 polysaccharide antigens.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>21529282</pmid><doi>10.1089/hyb.2010.0093</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Antigens Antigens, T-Independent - immunology Bacterial Infections - prevention & control Cell Adhesion Molecules - genetics Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Dextran Dextrans - immunology Dextrans - pharmacology Female Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - pharmacology Health aspects Immune response Immunity, Humoral - drug effects Immunoglobulin G Immunoglobulin G - analysis Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - analysis Immunoglobulin M - immunology Lectins, C-Type - genetics Lectins, C-Type - immunology Lectins, C-Type - metabolism Liver - immunology Lymphocytes T Macrophages Mice Mice, Inbred C57BL Mice, Knockout Ovalbumin Ovalbumin - immunology Ovalbumin - pharmacology Physiological aspects Polysaccharides Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Spleen - immunology T cells T-Lymphocytes - immunology Vaccination Vaccination - methods |
| title | Enhanced immune response of T-cell independent or dependent antigens in SIGN-R1 knock-out mice |
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