Asymmetric Arginine Dimethylation Determines Life Span in C. elegans by Regulating Forkhead Transcription Factor DAF-16

Arginine methylation is a widespread posttranslational modification of proteins catalyzed by a family of protein arginine methyltransferases (PRMTs). It is well established that PRMTs are implicated in various cellular processes, but their physiological roles remain unclear. Using nematodes with a l...

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Veröffentlicht in:	Cell metabolism 2011-05, Vol.13 (5), p.505-516
Hauptverfasser:	Takahashi, Yuta, Daitoku, Hiroaki, Hirota, Keiko, Tamiya, Hiroko, Yokoyama, Atsuko, Kako, Koichiro, Nagashima, Yusuke, Nakamura, Ayumi, Shimada, Takashi, Watanabe, Satoshi, Yamagata, Kazuyuki, Yasuda, Kayo, Ishii, Naoaki, Fukamizu, Akiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Amino Acid Sequence Animals Arginine - genetics Arginine - metabolism Blotting, Western Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation Immunoprecipitation Insulin - genetics Insulin - metabolism Longevity - genetics Methylation Molecular Sequence Data Mutation - genetics Phosphorylation Polymerase Chain Reaction Protein-Arginine N-Methyltransferases - genetics Protein-Arginine N-Methyltransferases - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptor, Insulin - genetics Receptor, Insulin - metabolism Sequence Homology, Amino Acid Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism
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