Simultaneous determination of rosuvastatin and atorvastatin in human serum using RP-HPLC/UV detection: Method development, validation and optimization of various experimental parameters

A novel, precise, accurate and rapid isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method was developed, optimized and validated for simultaneous determination of rosuvastatin and atorvastatin in human serum using naproxen sodium as an internal standard. E...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2011-03, Vol.879 (9), p.557-563
Hauptverfasser:	Shah, Yasar, Iqbal, Zafar, Ahmad, Lateef, Khan, Abad, Khan, Muhammad Imran, Nazir, Shabnam, Nasir, Fazli
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry anticholesteremic agents Atorvastatin Atorvastatin Calcium Biological and medical sciences blood serum Chromatography Chromatography, High Pressure Liquid - methods Chromatography, Reverse-Phase - methods detection limit Drug Stability Flow rate Fluorobenzenes - blood Fundamental and applied biological sciences. Psychology General pharmacology Heptanoic Acids - blood Human Humans Hydrogen-Ion Concentration Linear Models Liquids Medical sciences Methanol Naproxen Optimization pharmacokinetics Pharmacology. Drug treatments Pyrimidines - blood Pyrroles - blood Reproducibility of Results reversed-phase high performance liquid chromatography Rosuvastatin Rosuvastatin Calcium RP-HPLC/UV Sensitivity and Specificity Separation Serums Sodium Sulfonamides - blood Ultraviolet ultraviolet radiation Validation Water
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