Synthesis of biodegradable multiblock copolymers by click coupling of RAFT-generated heterotelechelic polyHPMA conjugates

A new strategy for the synthesis of biodegradable high molecular weight N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymeric carriers has been designed. An enzyme-sensitive, alkyne-functionalized, chain transfer agent (CTA-GFLG-alkyne; N α -(4-pentynoyl)- N δ -(4-cyano-4-(phenylcarbonothioylthio...

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Veröffentlicht in:	Reactive & functional polymers 2011-03, Vol.71 (3), p.294-302
Hauptverfasser:	Yang, Jiyuan, Luo, Kui, Pan, Huaizhong, Kopečková, Pavla, Kopeček, Jindřich
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biodegradable multiblock copolymer Biological and medical sciences Click reaction Drug carrier Exact sciences and technology General pharmacology Medical sciences N-(2-hydroxypropyl)methacrylamide (HPMA) Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts RAFT polymerization Telechelic
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