Synthetic cationic amphiphilic α -helical peptides as antimicrobial agents

Abstract Antimicrobial peptides (AMPs) secreted by the innate immune system are prevalent as the effective first-line of defense to overcome recurring microbial invasions. They have been widely accepted as the blueprints for the development of new antimicrobial agents for the treatment of drug resis...

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Veröffentlicht in:	Biomaterials 2011-03, Vol.32 (8), p.2204-2212
Hauptverfasser:	Wiradharma, Nikken, Khoe, Ulung, Hauser, Charlotte A.E, Seow, See Voon, Zhang, Shuguang, Yang, Yi-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Amino Acid Sequence Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides (AMP) Bacillus subtilis - drug effects Candida albicans - drug effects Cations - chemistry Cations - pharmacology Circular Dichroism Dentistry Hemolysis Hemolysis - drug effects Humans Membrane lysis Microbial Sensitivity Tests Minimum inhibitory concentration (MIC) Molecular Sequence Data Peptides - chemistry Peptides - genetics Peptides - pharmacology Protein Structure, Secondary Rats Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization α-Helix
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