Application of a validated stability-indicating chromatographic method to evaluate the reproducibility between batches of small peptides in solution

A stability-indicating reversed-phase high-performance liquid chromatographic method was developed and validated as per the International Conference on Harmonization (ICH) guidelines to evaluate the reproducibility of batches of synthetic peptides included in a stability program, in particular chole...

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Veröffentlicht in:	Analytica chimica acta 2010-08, Vol.675 (1), p.83-90
Hauptverfasser:	Oliva, Alexis, Llabrés, Matías, Fariña, José B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical chemistry Batch Chemistry Cholecystokinin - chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, High Pressure Liquid - methods Chromatography, Reverse-Phase - methods Degradation Exact sciences and technology Guidelines High-performance liquid chromatographic Liquids Mass Spectrometry Mathematical analysis Other chromatographic methods Peptides Protein Stability Quality control Reproducibility Reproducibility of Results Spectrometric and optical methods Stability Synthetic peptides
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