Electrochemical real-time detection of l-histidine via self-cleavage of DNAzymes

Herein, a rapid electrochemical biosensor for l-histidine based on highly specific, l-histidine-dependent DNAzymes is described. DNA with a single, sessile ribo-adenine, self-cleaves in the presence of l-histidine, allowing a ferrocene tag to transfer electrons to the electrode. The double-stranded...

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