Understanding the laminated layer of larval Echinococcus I: structure
Echinococcus larvae are protected by a massive carbohydrate-rich acellular structure, called the laminated layer. In spite of being widely considered the crucial element of these host–parasite interfaces, the laminated layer has been historically poorly understood. In fact, it is still often called...
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| Veröffentlicht in: | Trends in parasitology 2011-05, Vol.27 (5), p.204-213 |
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| creator | Díaz, Alvaro Casaravilla, Cecilia Irigoín, Florencia Lin, Gerardo Previato, José O Ferreira, Fernando |
| description | Echinococcus larvae are protected by a massive carbohydrate-rich acellular structure, called the laminated layer. In spite of being widely considered the crucial element of these host–parasite interfaces, the laminated layer has been historically poorly understood. In fact, it is still often called ‘chitinous’, ‘hyaline’ or ‘cuticular’ layer, or said to be composed of polysaccharides. However, over the past few years the laminated layer was found to be comprised of mucins bearing defined galactose-rich carbohydrates, and accompanied, in the case of Echinococcus granulosus, by calcium inositol hexakisphosphate deposits. In this review, the architecture and biosynthesis of this unusual structure is discussed at depth in terms of what is known and what needs to be discovered. |
| doi_str_mv | 10.1016/j.pt.2010.12.012 |
| format | Article |
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In this review, the architecture and biosynthesis of this unusual structure is discussed at depth in terms of what is known and what needs to be discovered.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>biosynthesis</subject><subject>Echinococcus - anatomy & histology</subject><subject>Echinococcus - chemistry</subject><subject>Echinococcus - ultrastructure</subject><subject>Echinococcus granulosus</subject><subject>Gastroenterology and Hepatology</subject><subject>General aspects</subject><subject>Host-Parasite Interactions</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Larva</subject><subject>larvae</subject><subject>Medical sciences</subject><subject>mucins</subject><subject>Mucins - chemistry</subject><subject>myo-inositol</subject><subject>Parasitic diseases</subject><subject>parasitology</subject><subject>polysaccharides</subject><subject>Polysaccharides - chemistry</subject><issn>1471-4922</issn><issn>1471-5007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1vEzEQhi0EoqVw5wR7QfSS4LHX-9FDJVSFUqkSh5Kz5Z0dtw4bb7C9lfLv8SoBJA4VvnhGft6Zkd9h7C3wJXCoPm2Wu7QUfE7FkoN4xk6hrGGhOK-fH-OyFeKEvYpxwzmoum5fshMBQtWybE7Zau17CjEZ3zt_X6QHKgazdd4k6nO0p1CMNgfh0QzFCh-cH3FEnGJxc1HEFCZMU6DX7IU1Q6Q3x_uMrb-svl99Xdx-u765-ny7QNXytBCIHSjqBXaqtS2JpuorqKCE2hprla1bKUoplbVC5Tdh0XSiqxQgNFahPGMfD3V3Yfw5UUx66yLSMBhP4xR1U5XQqlKITJ4_SUKtZFnJpuH_i9bQZpQfUAxjjIGs3gW3NWGvgevZEb3Ru6RnRzQInR3JknfH6lO3pf6P4LcFGfhwBExEM9hgPLr4lytBtJLPvd8fOGtGbe5DZtZ3uVP2On9g7p2JiwNB2YJHR0FHdOSRehcIk-5H99Scl_-IcXDe5Yl-0J7iZpyCz9Zq0DEL9N28W_NqAfB8JMhf-OvEMw</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Díaz, Alvaro</creator><creator>Casaravilla, Cecilia</creator><creator>Irigoín, Florencia</creator><creator>Lin, Gerardo</creator><creator>Previato, José O</creator><creator>Ferreira, Fernando</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Understanding the laminated layer of larval Echinococcus I: structure</title><author>Díaz, Alvaro ; 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences biosynthesis Echinococcus - anatomy & histology Echinococcus - chemistry Echinococcus - ultrastructure Echinococcus granulosus Gastroenterology and Hepatology General aspects Host-Parasite Interactions Infectious Disease Infectious diseases Larva larvae Medical sciences mucins Mucins - chemistry myo-inositol Parasitic diseases parasitology polysaccharides Polysaccharides - chemistry |
| title | Understanding the laminated layer of larval Echinococcus I: structure |
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