Hexabromocyclododecane Enantiomers: Microsomal Degradation and Patterns of Hydroxylated Metabolites

The degradation of the enantiomers of α-, β-, and γ-hexabromocyclododecane (HBCD) by phase I metabolism was investigated using induced rat liver microsomes. HBCD isomers were quantified using HPLC-MS/MS (ESI−) after separation on a combination of a reversed phase and a chiral analytical column. The...

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Veröffentlicht in:	Environmental science & technology 2011-05, Vol.45 (9), p.3938-3944
Hauptverfasser:	Esslinger, Susanne, Becker, Roland, Maul, Ronald, Nehls, Irene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Chemical compounds Chromatography, High Pressure Liquid Ecotoxicology, biological effects of pollution Environmental Pollutants - metabolism Environmental Processes Flame Retardants - metabolism Fundamental and applied biological sciences. Psychology General aspects Hydrocarbons, Brominated - metabolism Hydroxylation Liver Male Mass spectrometry Metabolism Microsomes, Liver - metabolism Rats Rats, Sprague-Dawley Stereoisomerism Tandem Mass Spectrometry
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