Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates
A 4-component antibody-phthalocyanine-polyethylene glycol-gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc-phthalocyanine derivative (photosensitiser) and a h...
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| Veröffentlicht in: | Photochemical & photobiological sciences 2011-05, Vol.10 (5), p.822-831 |
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| container_title | Photochemical & photobiological sciences |
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| creator | Stuchinskaya, Tanya Moreno, Miguel Cook, Michael J. Edwards, Dylan R. Russell, David A. |
| description | A 4-component antibody-phthalocyanine-polyethylene glycol-gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc-phthalocyanine derivative (photosensitiser) and a heterobifunctional polyethylene glycol. Anti-HER2 monoclonal antibodies were covalently bound to the nanoparticles
via
a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents. |
| doi_str_mv | 10.1039/c1pp05014a |
| format | Article |
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via
a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents.</description><identifier>ISSN: 1474-905X</identifier><identifier>EISSN: 1474-9092</identifier><identifier>DOI: 10.1039/c1pp05014a</identifier><identifier>PMID: 21455532</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antibodies, Monoclonal - chemistry ; Antibodies, Monoclonal - immunology ; Biochemistry ; Biomaterials ; Breast Neoplasms - drug therapy ; Cell Line, Tumor ; Chemistry ; Female ; Gold - chemistry ; Humans ; Indoles - chemistry ; Metal Nanoparticles - chemistry ; Photochemotherapy ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - therapeutic use ; Photosensitizing Agents - toxicity ; Physical Chemistry ; Plant Sciences ; Polyethylene Glycols - chemistry ; Receptor, ErbB-2 - immunology ; Singlet Oxygen - metabolism</subject><ispartof>Photochemical & photobiological sciences, 2011-05, Vol.10 (5), p.822-831</ispartof><rights>The Royal Society of Chemistry and Owner Societies 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-ab2e11e988deae7af7ec689b3cfc84dcd464116183f20ce7f178fa6fd6b83e8e3</citedby><cites>FETCH-LOGICAL-c465t-ab2e11e988deae7af7ec689b3cfc84dcd464116183f20ce7f178fa6fd6b83e8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1039/c1pp05014a$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1039/c1pp05014a$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21455532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stuchinskaya, Tanya</creatorcontrib><creatorcontrib>Moreno, Miguel</creatorcontrib><creatorcontrib>Cook, Michael J.</creatorcontrib><creatorcontrib>Edwards, Dylan R.</creatorcontrib><creatorcontrib>Russell, David A.</creatorcontrib><title>Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates</title><title>Photochemical & photobiological sciences</title><addtitle>Photochem Photobiol Sci</addtitle><addtitle>Photochem Photobiol Sci</addtitle><description>A 4-component antibody-phthalocyanine-polyethylene glycol-gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc-phthalocyanine derivative (photosensitiser) and a heterobifunctional polyethylene glycol. Anti-HER2 monoclonal antibodies were covalently bound to the nanoparticles
via
a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents.</description><subject>Antibodies, Monoclonal - chemistry</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biochemistry</subject><subject>Biomaterials</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Cell Line, Tumor</subject><subject>Chemistry</subject><subject>Female</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Indoles - chemistry</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Photochemotherapy</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Photosensitizing Agents - toxicity</subject><subject>Physical Chemistry</subject><subject>Plant Sciences</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Receptor, ErbB-2 - immunology</subject><subject>Singlet Oxygen - metabolism</subject><issn>1474-905X</issn><issn>1474-9092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1OwzAQhC0EoqVw4QGQb0iggJ04iXNEFX9SJS5F4hZtnHWaKrWD7Rz69qRqKRdOu9J-M9oZQq45e-AsKR4V73uWMi7ghEy5yEVUsCI-Pe7p14RceL9mjKciy8_JJOYiTdMknhK7BNdgwJr2KxtsvTWwaRUNK3TQb6nVtHIIPlAFRqGjCrvO08G3pqFgQluNkqhfhRV0Vm3BtAajxnY1NWBsDy60qkOqrFkPDQT0l-RMQ-fx6jBn5PPleTl_ixYfr-_zp0WkRJaGCKoYOcdCyhoBc9A5qkwWVaK0kqJWtcgE5xmXiY6ZwlzzXGrIdJ1VMkGJyYzc7n17Z78H9KHctH73PBi0gy_lqC9EKouRvNuTylnvHeqyd-0G3LbkrNz1W_71O8I3B9uh2mB9RH8LHYH7PeDHk2nQlWs7ODNG_c_uB5WXiJU</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Stuchinskaya, Tanya</creator><creator>Moreno, Miguel</creator><creator>Cook, Michael J.</creator><creator>Edwards, Dylan R.</creator><creator>Russell, David A.</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201105</creationdate><title>Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates</title><author>Stuchinskaya, Tanya ; 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via
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| ispartof | Photochemical & photobiological sciences, 2011-05, Vol.10 (5), p.822-831 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Springer Nature - Complete Springer Journals |
| subjects | Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Biochemistry Biomaterials Breast Neoplasms - drug therapy Cell Line, Tumor Chemistry Female Gold - chemistry Humans Indoles - chemistry Metal Nanoparticles - chemistry Photochemotherapy Photosensitizing Agents - chemistry Photosensitizing Agents - therapeutic use Photosensitizing Agents - toxicity Physical Chemistry Plant Sciences Polyethylene Glycols - chemistry Receptor, ErbB-2 - immunology Singlet Oxygen - metabolism |
| title | Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates |
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