Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing
In this study, carbon fiber electrodes were incorporated within a hollow microneedle array, which was fabricated using a digital micromirror device-based stereolithography instrument. Cell proliferation on the acrylate-based polymer used in microneedle fabrication was examined with human dermal fibr...
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| Veröffentlicht in: | Biomicrofluidics 2011-03, Vol.5 (1), p.013415-013415-14 |
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| creator | Miller, Philip R. Gittard, Shaun D. Edwards, Thayne L. Lopez, DeAnna M. Xiao, Xiaoyin Wheeler, David R. Monteiro-Riviere, Nancy A. Brozik, Susan M. Polsky, Ronen Narayan, Roger J. |
| description | In this study, carbon fiber electrodes were incorporated within a hollow microneedle array, which was fabricated using a digital micromirror device-based stereolithography instrument. Cell proliferation on the acrylate-based polymer used in microneedle fabrication was examined with human dermal fibroblasts and neonatal human epidermal keratinocytes. Studies involving full-thickness cadaveric porcine skin and trypan blue dye demonstrated that the hollow microneedles remained intact after puncturing the outermost layer of cadaveric porcine skin. The carbon fibers underwent chemical modification in order to enable detection of hydrogen peroxide and ascorbic acid; electrochemical measurements were demonstrated using integrated electrode-hollow microneedle devices. |
| doi_str_mv | 10.1063/1.3569945 |
| format | Article |
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| source | AIP Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Special Topic: Biological Microfluidics in Tissue Engineering and Regenerative Medicine (Guest Editor: Suwan Jayasinghe) |
| title | Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing |
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