ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment

OBJECTIVEATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood–brain barrier. Intestinal ABCB1 actively transports drugs from the cell membrane and prevents them from ente...

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Veröffentlicht in:	Pharmacogenetics and genomics 2011-04, Vol.21 (4), p.163-170
Hauptverfasser:	Lin, Keh-Ming, Chiu, Yen-Feng, Tsai, I-Ju, Chen, Chia-Hui, Shen, Winston W, Liu, Shu Chih, Lu, Shao-Chun, Liu, Chia-Yih, Hsiao, Mei-Chun, Tang, Hwa-Sheng, Liu, Shen-Ing, Chang, Liang-Huey, Wu, Chi-Shin, Tsou, Hsiao-Hui, Tsai, Ming-Hsien, Chen, Chun-Yu, Wang, Su-Mei, Kuo, Hsiang-Wei, Hsu, Ya-Ting, Liu, Yu-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Antidepressive Agents, Second-Generation - blood Antidepressive Agents, Second-Generation - pharmacology Antidepressive Agents, Second-Generation - therapeutic use ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biological and medical sciences Citalopram - blood Citalopram - pharmacology Citalopram - therapeutic use Depression Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics General pharmacology Genotype Haplotypes Humans Medical sciences Mood disorders Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry
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