Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage
Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage. Intracerebral hemorrhage was induced by stereotactic injection of collagenase Type VII...
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| Veröffentlicht in: | Stroke (1970) 2011-05, Vol.42 (5), p.1469-1472 |
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| container_title | Stroke (1970) |
| container_volume | 42 |
| creator | FUJIWARA, Norio MANDEVILLE, Emiri T XIAOKUN GENG YUMIN LUO ARAI, Ken XIAOYING WANG XUNMING JI SINGHAL, Aneesh B LO, Eng H |
| description | Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage.
Intracerebral hemorrhage was induced by stereotactic injection of collagenase Type VII (0.5 U) into the right striatum of male Sprague-Dawley rats. One hour later, rats were randomized into controls (n=13) versus NBO treatment (n=13). NBO was applied for 2 hours. Hemorrhagic blood volume, brain water content, and neurological outcomes (forelimb placement test, forelimb asymmetry, neuroscore) were quantified at 72 hours. Experiments were repeated in a second independent laboratory to assess reproducibility in neurological outcomes (n=10 per group).
NBO did not worsen hemorrhage severity or brain edema. There were no significant differences in hemorrhagic blood volumes (control, 6.4±0.9 μL versus NBO, 7.0±2.1 μL; P=0.18) or brain water content (control, 81.9%±1.1% versus NBO, 81.6%±0.5%; P=0.58). NBO did not affect any of the neurological outcome tests in the primary or secondary studies.
NBO therapy may not worsen outcomes in intracerebral hemorrhage. |
| doi_str_mv | 10.1161/STROKEAHA.110.593350 |
| format | Article |
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Intracerebral hemorrhage was induced by stereotactic injection of collagenase Type VII (0.5 U) into the right striatum of male Sprague-Dawley rats. One hour later, rats were randomized into controls (n=13) versus NBO treatment (n=13). NBO was applied for 2 hours. Hemorrhagic blood volume, brain water content, and neurological outcomes (forelimb placement test, forelimb asymmetry, neuroscore) were quantified at 72 hours. Experiments were repeated in a second independent laboratory to assess reproducibility in neurological outcomes (n=10 per group).
NBO did not worsen hemorrhage severity or brain edema. There were no significant differences in hemorrhagic blood volumes (control, 6.4±0.9 μL versus NBO, 7.0±2.1 μL; P=0.18) or brain water content (control, 81.9%±1.1% versus NBO, 81.6%±0.5%; P=0.58). NBO did not affect any of the neurological outcome tests in the primary or secondary studies.
NBO therapy may not worsen outcomes in intracerebral hemorrhage.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.110.593350</identifier><identifier>PMID: 21415401</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Blood Volume - drug effects ; Brain - drug effects ; Brain - metabolism ; Cerebral Hemorrhage - metabolism ; Cerebral Hemorrhage - therapy ; Male ; Medical sciences ; Models, Animal ; Neurology ; Neuropharmacology ; Neuroprotective agent ; Oxygen - pharmacology ; Oxygen Inhalation Therapy - methods ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system ; Water - metabolism</subject><ispartof>Stroke (1970), 2011-05, Vol.42 (5), p.1469-1472</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-56fdde9705a0b4dcb848941a12164df528db292928524f2bcc9e96347af22c1b3</citedby><cites>FETCH-LOGICAL-c382t-56fdde9705a0b4dcb848941a12164df528db292928524f2bcc9e96347af22c1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24133886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21415401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FUJIWARA, Norio</creatorcontrib><creatorcontrib>MANDEVILLE, Emiri T</creatorcontrib><creatorcontrib>XIAOKUN GENG</creatorcontrib><creatorcontrib>YUMIN LUO</creatorcontrib><creatorcontrib>ARAI, Ken</creatorcontrib><creatorcontrib>XIAOYING WANG</creatorcontrib><creatorcontrib>XUNMING JI</creatorcontrib><creatorcontrib>SINGHAL, Aneesh B</creatorcontrib><creatorcontrib>LO, Eng H</creatorcontrib><title>Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage.
Intracerebral hemorrhage was induced by stereotactic injection of collagenase Type VII (0.5 U) into the right striatum of male Sprague-Dawley rats. One hour later, rats were randomized into controls (n=13) versus NBO treatment (n=13). NBO was applied for 2 hours. Hemorrhagic blood volume, brain water content, and neurological outcomes (forelimb placement test, forelimb asymmetry, neuroscore) were quantified at 72 hours. Experiments were repeated in a second independent laboratory to assess reproducibility in neurological outcomes (n=10 per group).
NBO did not worsen hemorrhage severity or brain edema. There were no significant differences in hemorrhagic blood volumes (control, 6.4±0.9 μL versus NBO, 7.0±2.1 μL; P=0.18) or brain water content (control, 81.9%±1.1% versus NBO, 81.6%±0.5%; P=0.58). NBO did not affect any of the neurological outcome tests in the primary or secondary studies.
NBO therapy may not worsen outcomes in intracerebral hemorrhage.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Volume - drug effects</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cerebral Hemorrhage - metabolism</subject><subject>Cerebral Hemorrhage - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Oxygen - pharmacology</subject><subject>Oxygen Inhalation Therapy - methods</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Water - metabolism</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1PwjAUhhujEUT_gTG9MV4N-7m1l4SgGBESxOul61qY2VZsRyL_3hoQcy5O3uR5z8cLwC1GQ4xT_Pi-Wi5eJ6PpKEo05JJSjs5AH3PCEpYScQ76CFGZECZlD1yF8IkQIlTwS9AjmGHOEO6D-cRaozvoLJw737hC-UrDxfd-bVq42hivtntYtVDBpergmytN_cu-tJ1X2nhTeFXDqWmc9xu1Ntfgwqo6mJtjH4CPp8lqPE1mi-eX8WiWaCpIl_DUlqWRGeIKFazUhWBCMqwwwSkrLSeiLIiMJeI3lhRaSyNTyjJlCdG4oAPwcJi79e5rZ0KXN1XQpq5Va9wu5CKlWSpplkWSHUjtXQje2Hzrq0b5fY5R_htkfgoySpQfgoy2u-OCXdGY8mT6Sy4C90dABa1q61Wrq_DPMUypiGf8AAEzewo</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>FUJIWARA, Norio</creator><creator>MANDEVILLE, Emiri T</creator><creator>XIAOKUN GENG</creator><creator>YUMIN LUO</creator><creator>ARAI, Ken</creator><creator>XIAOYING WANG</creator><creator>XUNMING JI</creator><creator>SINGHAL, Aneesh B</creator><creator>LO, Eng H</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage</title><author>FUJIWARA, Norio ; MANDEVILLE, Emiri T ; XIAOKUN GENG ; YUMIN LUO ; ARAI, Ken ; XIAOYING WANG ; XUNMING JI ; SINGHAL, Aneesh B ; LO, Eng H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-56fdde9705a0b4dcb848941a12164df528db292928524f2bcc9e96347af22c1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Volume - drug effects</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cerebral Hemorrhage - metabolism</topic><topic>Cerebral Hemorrhage - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Oxygen - pharmacology</topic><topic>Oxygen Inhalation Therapy - methods</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Water - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUJIWARA, Norio</creatorcontrib><creatorcontrib>MANDEVILLE, Emiri T</creatorcontrib><creatorcontrib>XIAOKUN GENG</creatorcontrib><creatorcontrib>YUMIN LUO</creatorcontrib><creatorcontrib>ARAI, Ken</creatorcontrib><creatorcontrib>XIAOYING WANG</creatorcontrib><creatorcontrib>XUNMING JI</creatorcontrib><creatorcontrib>SINGHAL, Aneesh B</creatorcontrib><creatorcontrib>LO, Eng H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUJIWARA, Norio</au><au>MANDEVILLE, Emiri T</au><au>XIAOKUN GENG</au><au>YUMIN LUO</au><au>ARAI, Ken</au><au>XIAOYING WANG</au><au>XUNMING JI</au><au>SINGHAL, Aneesh B</au><au>LO, Eng H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>42</volume><issue>5</issue><spage>1469</spage><epage>1472</epage><pages>1469-1472</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage.
Intracerebral hemorrhage was induced by stereotactic injection of collagenase Type VII (0.5 U) into the right striatum of male Sprague-Dawley rats. One hour later, rats were randomized into controls (n=13) versus NBO treatment (n=13). NBO was applied for 2 hours. Hemorrhagic blood volume, brain water content, and neurological outcomes (forelimb placement test, forelimb asymmetry, neuroscore) were quantified at 72 hours. Experiments were repeated in a second independent laboratory to assess reproducibility in neurological outcomes (n=10 per group).
NBO did not worsen hemorrhage severity or brain edema. There were no significant differences in hemorrhagic blood volumes (control, 6.4±0.9 μL versus NBO, 7.0±2.1 μL; P=0.18) or brain water content (control, 81.9%±1.1% versus NBO, 81.6%±0.5%; P=0.58). NBO did not affect any of the neurological outcome tests in the primary or secondary studies.
NBO therapy may not worsen outcomes in intracerebral hemorrhage.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21415401</pmid><doi>10.1161/STROKEAHA.110.593350</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Blood Volume - drug effects Brain - drug effects Brain - metabolism Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - therapy Male Medical sciences Models, Animal Neurology Neuropharmacology Neuroprotective agent Oxygen - pharmacology Oxygen Inhalation Therapy - methods Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Treatment Outcome Vascular diseases and vascular malformations of the nervous system Water - metabolism |
| title | Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage |
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