Primary cutaneous lymphoma: two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre
Summary Background Epidemiological data on primary cutaneous lymphomas (PCLs) are rare and have not previously been investigated in Switzerland. Objective To analyse variations in demographics, the pattern of subtypes and staging during the two 10‐year intervals, 1990–1999 and 2000–2009. Methods ...
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| Veröffentlicht in: | British journal of dermatology (1951) 2011-05, Vol.164 (5), p.1071-1077 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 164 |
| creator | Jenni, D. Karpova, M.B. Seifert, B. Golling, Ph Cozzio, A. Kempf, W. French, L.E. Dummer, R. |
| description | Summary
Background Epidemiological data on primary cutaneous lymphomas (PCLs) are rare and have not previously been investigated in Switzerland.
Objective To analyse variations in demographics, the pattern of subtypes and staging during the two 10‐year intervals, 1990–1999 and 2000–2009.
Methods This was a descriptive study of 263 patients with PCL based on a retrospective review and reassessment according to the World Health Organization/European Organization for Research and Treatment of Cancer classification.
Results Change was observed in the pattern of cutaneous T‐cell lymphoma subtypes: the frequency of Sézary syndrome decreased from 17% to 7% and the frequency of CD30+ lymphoproliferative disorders increased from 7% to 18% (overall P = 0·04). Staging of PCL showed a higher number of cases of early‐stage mycosis fungoides (P = 0·01). In relation to the international data, the Zürich group had a higher number of patients with Sézary syndrome (11% vs. 3%) and marginal cell lymphoma (14% vs. 5–7%). In addition, comparison of the survival data showed prolonged median overall survival of Zürich patients with Sézary syndrome in the second 10‐year interval (6·5 vs. 2–4 years).
Conclusion The increasing frequency of marginal cell lymphoma and CD30+ lymphoproliferative disorders might depend on an increased awareness of these diseases in the medical community, driven by progress in the classification and staging of these disease entities. |
| doi_str_mv | 10.1111/j.1365-2133.2010.10143.x |
| format | Article |
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Background Epidemiological data on primary cutaneous lymphomas (PCLs) are rare and have not previously been investigated in Switzerland.
Objective To analyse variations in demographics, the pattern of subtypes and staging during the two 10‐year intervals, 1990–1999 and 2000–2009.
Methods This was a descriptive study of 263 patients with PCL based on a retrospective review and reassessment according to the World Health Organization/European Organization for Research and Treatment of Cancer classification.
Results Change was observed in the pattern of cutaneous T‐cell lymphoma subtypes: the frequency of Sézary syndrome decreased from 17% to 7% and the frequency of CD30+ lymphoproliferative disorders increased from 7% to 18% (overall P = 0·04). Staging of PCL showed a higher number of cases of early‐stage mycosis fungoides (P = 0·01). In relation to the international data, the Zürich group had a higher number of patients with Sézary syndrome (11% vs. 3%) and marginal cell lymphoma (14% vs. 5–7%). In addition, comparison of the survival data showed prolonged median overall survival of Zürich patients with Sézary syndrome in the second 10‐year interval (6·5 vs. 2–4 years).
Conclusion The increasing frequency of marginal cell lymphoma and CD30+ lymphoproliferative disorders might depend on an increased awareness of these diseases in the medical community, driven by progress in the classification and staging of these disease entities.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2010.10143.x</identifier><identifier>PMID: 21083546</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Dermatology ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma - classification ; Lymphoma - epidemiology ; Lymphoma - pathology ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Skin Neoplasms - classification ; Skin Neoplasms - epidemiology ; Skin Neoplasms - pathology ; Survival Analysis ; Switzerland - epidemiology ; Young Adult</subject><ispartof>British journal of dermatology (1951), 2011-05, Vol.164 (5), p.1071-1077</ispartof><rights>2011 The Authors. BJD © 2011 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. BJD © 2011 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-a98b641c5c7054aa7b8f1e1d7cf45154c00b0f4c0293d3dce6366b7e280c328e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2010.10143.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2010.10143.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24186052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21083546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jenni, D.</creatorcontrib><creatorcontrib>Karpova, M.B.</creatorcontrib><creatorcontrib>Seifert, B.</creatorcontrib><creatorcontrib>Golling, Ph</creatorcontrib><creatorcontrib>Cozzio, A.</creatorcontrib><creatorcontrib>Kempf, W.</creatorcontrib><creatorcontrib>French, L.E.</creatorcontrib><creatorcontrib>Dummer, R.</creatorcontrib><title>Primary cutaneous lymphoma: two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Epidemiological data on primary cutaneous lymphomas (PCLs) are rare and have not previously been investigated in Switzerland.
Objective To analyse variations in demographics, the pattern of subtypes and staging during the two 10‐year intervals, 1990–1999 and 2000–2009.
Methods This was a descriptive study of 263 patients with PCL based on a retrospective review and reassessment according to the World Health Organization/European Organization for Research and Treatment of Cancer classification.
Results Change was observed in the pattern of cutaneous T‐cell lymphoma subtypes: the frequency of Sézary syndrome decreased from 17% to 7% and the frequency of CD30+ lymphoproliferative disorders increased from 7% to 18% (overall P = 0·04). Staging of PCL showed a higher number of cases of early‐stage mycosis fungoides (P = 0·01). In relation to the international data, the Zürich group had a higher number of patients with Sézary syndrome (11% vs. 3%) and marginal cell lymphoma (14% vs. 5–7%). In addition, comparison of the survival data showed prolonged median overall survival of Zürich patients with Sézary syndrome in the second 10‐year interval (6·5 vs. 2–4 years).
Conclusion The increasing frequency of marginal cell lymphoma and CD30+ lymphoproliferative disorders might depend on an increased awareness of these diseases in the medical community, driven by progress in the classification and staging of these disease entities.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dermatology</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma - classification</subject><subject>Lymphoma - epidemiology</subject><subject>Lymphoma - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms - classification</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - pathology</subject><subject>Survival Analysis</subject><subject>Switzerland - epidemiology</subject><subject>Young Adult</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EokvhLyBfEKdsx5nE8XJAolvYllaA-BBHy3Emwku-sBPt7r9v0ixbX8b2PHqkmZcxLmApxnOxXQqUaRQLxGUM0y-IBJf7J2xxajxlCwDIIlhJPGMvQtgCCIQUnrOzWIDCNJEL1n_zrjb-wO3Qm4baIfDqUHd_2tq84_2ujQqypiBu27oz3oW24a7hhndtN1Smd-O7LXkskVsTKPDSt_XY_rFzIfCefO8muaeSvDcVt9T0nl6yZ6WpAr061nP269PHn-vr6O7r5mb94S6yqBRGZqVymQib2gzSxJgsV6UgUWS2TFKRJhYgh3Is8QoLLCxJlDLPKFZgMVaE5-zt7O18-2-g0OvaBUtVNU-qlcRMqkzEI_n6SA55TYXu5q3o_4sagTdHwARrqtKbxrrwyCVCSUgn0fuZ27mKDqe-AD0Fp7d6ykdP-egpOP0QnN7ry89XD9dREM0CF3ranwTG_9UywyzVv79sdILJ1Xpz-13HeA83d5qg</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Jenni, D.</creator><creator>Karpova, M.B.</creator><creator>Seifert, B.</creator><creator>Golling, Ph</creator><creator>Cozzio, A.</creator><creator>Kempf, W.</creator><creator>French, L.E.</creator><creator>Dummer, R.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201105</creationdate><title>Primary cutaneous lymphoma: two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre</title><author>Jenni, D. ; Karpova, M.B. ; Seifert, B. ; Golling, Ph ; Cozzio, A. ; Kempf, W. ; French, L.E. ; Dummer, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-a98b641c5c7054aa7b8f1e1d7cf45154c00b0f4c0293d3dce6366b7e280c328e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dermatology</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma - classification</topic><topic>Lymphoma - epidemiology</topic><topic>Lymphoma - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms - classification</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - pathology</topic><topic>Survival Analysis</topic><topic>Switzerland - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jenni, D.</creatorcontrib><creatorcontrib>Karpova, M.B.</creatorcontrib><creatorcontrib>Seifert, B.</creatorcontrib><creatorcontrib>Golling, Ph</creatorcontrib><creatorcontrib>Cozzio, A.</creatorcontrib><creatorcontrib>Kempf, W.</creatorcontrib><creatorcontrib>French, L.E.</creatorcontrib><creatorcontrib>Dummer, R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jenni, D.</au><au>Karpova, M.B.</au><au>Seifert, B.</au><au>Golling, Ph</au><au>Cozzio, A.</au><au>Kempf, W.</au><au>French, L.E.</au><au>Dummer, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary cutaneous lymphoma: two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2011-05</date><risdate>2011</risdate><volume>164</volume><issue>5</issue><spage>1071</spage><epage>1077</epage><pages>1071-1077</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Epidemiological data on primary cutaneous lymphomas (PCLs) are rare and have not previously been investigated in Switzerland.
Objective To analyse variations in demographics, the pattern of subtypes and staging during the two 10‐year intervals, 1990–1999 and 2000–2009.
Methods This was a descriptive study of 263 patients with PCL based on a retrospective review and reassessment according to the World Health Organization/European Organization for Research and Treatment of Cancer classification.
Results Change was observed in the pattern of cutaneous T‐cell lymphoma subtypes: the frequency of Sézary syndrome decreased from 17% to 7% and the frequency of CD30+ lymphoproliferative disorders increased from 7% to 18% (overall P = 0·04). Staging of PCL showed a higher number of cases of early‐stage mycosis fungoides (P = 0·01). In relation to the international data, the Zürich group had a higher number of patients with Sézary syndrome (11% vs. 3%) and marginal cell lymphoma (14% vs. 5–7%). In addition, comparison of the survival data showed prolonged median overall survival of Zürich patients with Sézary syndrome in the second 10‐year interval (6·5 vs. 2–4 years).
Conclusion The increasing frequency of marginal cell lymphoma and CD30+ lymphoproliferative disorders might depend on an increased awareness of these diseases in the medical community, driven by progress in the classification and staging of these disease entities.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21083546</pmid><doi>10.1111/j.1365-2133.2010.10143.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2011-05, Vol.164 (5), p.1071-1077 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Dermatology Female Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma - classification Lymphoma - epidemiology Lymphoma - pathology Male Medical sciences Middle Aged Neoplasm Staging Retrospective Studies Skin Neoplasms - classification Skin Neoplasms - epidemiology Skin Neoplasms - pathology Survival Analysis Switzerland - epidemiology Young Adult |
| title | Primary cutaneous lymphoma: two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre |
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