The Intracellular Distal Tail of the Na+/H+ Exchanger NHE1 Is Intrinsically Disordered: Implications for NHE1 Trafficking

Intrinsic disorder is important for protein regulation, yet its role in regulation of ion transport proteins is essentially uninvestigated. The ubiquitous plasma membrane carrier protein Na+/H+ Exchanger isoform 1 (NHE1) plays pivotal roles in cellular pH and volume homeostasis, and its dysfunction...

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Veröffentlicht in:	Biochemistry (Easton) 2011-05, Vol.50 (17), p.3469-3480
Hauptverfasser:	Nørholm, Ann-Beth, Hendus-Altenburger, Ruth, Bjerre, Gabriel, Kjaergaard, Magnus, Pedersen, Stine F, Kragelund, Birthe B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Cation Transport Proteins - chemistry Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell Line Cell Membrane - metabolism Computational Biology Conserved Sequence Fish Proteins - chemistry Flounder Glycosylation Humans Molecular Sequence Data Mutation Nuclear Magnetic Resonance, Biomolecular Protein Structure, Secondary Protein Transport Scattering, Small Angle Sequence Alignment Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers - chemistry Sodium-Hydrogen Exchangers - genetics Sodium-Hydrogen Exchangers - metabolism Species Specificity X-Ray Diffraction
Online-Zugang:	Volltext
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