Depression comorbidity in spinocerebellar ataxia
This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient...
Gespeichert in:
Veröffentlicht in: | Movement disorders 2011-04, Vol.26 (5), p.870-876 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 876 |
---|---|
container_issue | 5 |
container_start_page | 870 |
container_title | Movement disorders |
container_volume | 26 |
creator | Schmitz-Hübsch, Tanja Coudert, Mathieu Tezenas du Montcel, Sophie Giunti, Paola Labrum, Robyn Dürr, Alexandra Ribai, Pascale Charles, Perrine Linnemann, Christoph Schöls, Ludger Rakowicz, Maryla Rola, Rafal Zdzienicka, Elszbieta Fancellu, Roberto Mariotti, Caterina Baliko, Lazlo Melegh, Bela Filla, Alessandro Salvatore, Elena van de Warrenburg, Bart P.C. Szymanski, Sandra Infante, Jon Timmann, Dagmar Boesch, Sylvia Depondt, Chantal Kang, Jun-Suk Schulz, Jörg B. Klopstock, Thomas Lossnitzer, Nicole Löwe, Bernd Frick, Caroline Rottländer, Daniela Schlaepfer, Thomas E. Klockgether, Thomas |
description | This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society |
doi_str_mv | 10.1002/mds.23698 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_863768068</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>863768068</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4638-249ebb17adfbef6071c71e20af96dd48322268540075e9418418f3e215c9d5ac3</originalsourceid><addsrcrecordid>eNp1kMtKw0AUQAdRbK0u_AHJTlyknUfmkaW0WoWqCxWXw2RyA6N51JkU2783NW13woW7OfdwOQhdEjwmGNNJlYcxZSJVR2hIOCOxolweoyFWiseMKD5AZyF8YkwIJ-IUDShJmEyVGiI8g6WHEFxTR7apGp-53LWbyNVRWLq6seAhg7I0PjKtWTtzjk4KUwa42O0Rer-_e5s-xIuX-eP0dhHbRDAV0ySFLCPS5EUGhcCSWEmAYlOkIs8TxSilQvEEY8khTYjqpmBACbdpzo1lI3Tde5e--V5BaHXlgt1-UkOzCloJJoXCQnXkTU9a34TgodBL7yrjN5pgve2juz76r0_HXu2sq6yC_EDug3TApAd-XAmb_036afa6V8b9hQstrA8Xxn9pIZnk-uN5rqkgkgkqdcJ-AWu7fMw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>863768068</pqid></control><display><type>article</type><title>Depression comorbidity in spinocerebellar ataxia</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Schmitz-Hübsch, Tanja ; Coudert, Mathieu ; Tezenas du Montcel, Sophie ; Giunti, Paola ; Labrum, Robyn ; Dürr, Alexandra ; Ribai, Pascale ; Charles, Perrine ; Linnemann, Christoph ; Schöls, Ludger ; Rakowicz, Maryla ; Rola, Rafal ; Zdzienicka, Elszbieta ; Fancellu, Roberto ; Mariotti, Caterina ; Baliko, Lazlo ; Melegh, Bela ; Filla, Alessandro ; Salvatore, Elena ; van de Warrenburg, Bart P.C. ; Szymanski, Sandra ; Infante, Jon ; Timmann, Dagmar ; Boesch, Sylvia ; Depondt, Chantal ; Kang, Jun-Suk ; Schulz, Jörg B. ; Klopstock, Thomas ; Lossnitzer, Nicole ; Löwe, Bernd ; Frick, Caroline ; Rottländer, Daniela ; Schlaepfer, Thomas E. ; Klockgether, Thomas</creator><creatorcontrib>Schmitz-Hübsch, Tanja ; Coudert, Mathieu ; Tezenas du Montcel, Sophie ; Giunti, Paola ; Labrum, Robyn ; Dürr, Alexandra ; Ribai, Pascale ; Charles, Perrine ; Linnemann, Christoph ; Schöls, Ludger ; Rakowicz, Maryla ; Rola, Rafal ; Zdzienicka, Elszbieta ; Fancellu, Roberto ; Mariotti, Caterina ; Baliko, Lazlo ; Melegh, Bela ; Filla, Alessandro ; Salvatore, Elena ; van de Warrenburg, Bart P.C. ; Szymanski, Sandra ; Infante, Jon ; Timmann, Dagmar ; Boesch, Sylvia ; Depondt, Chantal ; Kang, Jun-Suk ; Schulz, Jörg B. ; Klopstock, Thomas ; Lossnitzer, Nicole ; Löwe, Bernd ; Frick, Caroline ; Rottländer, Daniela ; Schlaepfer, Thomas E. ; Klockgether, Thomas</creatorcontrib><description>This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.23698</identifier><identifier>PMID: 21437988</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Antidepressive Agents - therapeutic use ; cerebellum ; Comorbidity ; depression ; Depression - drug therapy ; Depression - epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; prevalence studies ; spinocerebellar ataxia ; Spinocerebellar Ataxias - epidemiology ; Spinocerebellar Ataxias - genetics</subject><ispartof>Movement disorders, 2011-04, Vol.26 (5), p.870-876</ispartof><rights>Copyright © 2011 Movement Disorder Society</rights><rights>Copyright © 2011 Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4638-249ebb17adfbef6071c71e20af96dd48322268540075e9418418f3e215c9d5ac3</citedby><cites>FETCH-LOGICAL-c4638-249ebb17adfbef6071c71e20af96dd48322268540075e9418418f3e215c9d5ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.23698$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.23698$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21437988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmitz-Hübsch, Tanja</creatorcontrib><creatorcontrib>Coudert, Mathieu</creatorcontrib><creatorcontrib>Tezenas du Montcel, Sophie</creatorcontrib><creatorcontrib>Giunti, Paola</creatorcontrib><creatorcontrib>Labrum, Robyn</creatorcontrib><creatorcontrib>Dürr, Alexandra</creatorcontrib><creatorcontrib>Ribai, Pascale</creatorcontrib><creatorcontrib>Charles, Perrine</creatorcontrib><creatorcontrib>Linnemann, Christoph</creatorcontrib><creatorcontrib>Schöls, Ludger</creatorcontrib><creatorcontrib>Rakowicz, Maryla</creatorcontrib><creatorcontrib>Rola, Rafal</creatorcontrib><creatorcontrib>Zdzienicka, Elszbieta</creatorcontrib><creatorcontrib>Fancellu, Roberto</creatorcontrib><creatorcontrib>Mariotti, Caterina</creatorcontrib><creatorcontrib>Baliko, Lazlo</creatorcontrib><creatorcontrib>Melegh, Bela</creatorcontrib><creatorcontrib>Filla, Alessandro</creatorcontrib><creatorcontrib>Salvatore, Elena</creatorcontrib><creatorcontrib>van de Warrenburg, Bart P.C.</creatorcontrib><creatorcontrib>Szymanski, Sandra</creatorcontrib><creatorcontrib>Infante, Jon</creatorcontrib><creatorcontrib>Timmann, Dagmar</creatorcontrib><creatorcontrib>Boesch, Sylvia</creatorcontrib><creatorcontrib>Depondt, Chantal</creatorcontrib><creatorcontrib>Kang, Jun-Suk</creatorcontrib><creatorcontrib>Schulz, Jörg B.</creatorcontrib><creatorcontrib>Klopstock, Thomas</creatorcontrib><creatorcontrib>Lossnitzer, Nicole</creatorcontrib><creatorcontrib>Löwe, Bernd</creatorcontrib><creatorcontrib>Frick, Caroline</creatorcontrib><creatorcontrib>Rottländer, Daniela</creatorcontrib><creatorcontrib>Schlaepfer, Thomas E.</creatorcontrib><creatorcontrib>Klockgether, Thomas</creatorcontrib><title>Depression comorbidity in spinocerebellar ataxia</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</description><subject>Aged</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>cerebellum</subject><subject>Comorbidity</subject><subject>depression</subject><subject>Depression - drug therapy</subject><subject>Depression - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>prevalence studies</subject><subject>spinocerebellar ataxia</subject><subject>Spinocerebellar Ataxias - epidemiology</subject><subject>Spinocerebellar Ataxias - genetics</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKw0AUQAdRbK0u_AHJTlyknUfmkaW0WoWqCxWXw2RyA6N51JkU2783NW13woW7OfdwOQhdEjwmGNNJlYcxZSJVR2hIOCOxolweoyFWiseMKD5AZyF8YkwIJ-IUDShJmEyVGiI8g6WHEFxTR7apGp-53LWbyNVRWLq6seAhg7I0PjKtWTtzjk4KUwa42O0Rer-_e5s-xIuX-eP0dhHbRDAV0ySFLCPS5EUGhcCSWEmAYlOkIs8TxSilQvEEY8khTYjqpmBACbdpzo1lI3Tde5e--V5BaHXlgt1-UkOzCloJJoXCQnXkTU9a34TgodBL7yrjN5pgve2juz76r0_HXu2sq6yC_EDug3TApAd-XAmb_036afa6V8b9hQstrA8Xxn9pIZnk-uN5rqkgkgkqdcJ-AWu7fMw</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Schmitz-Hübsch, Tanja</creator><creator>Coudert, Mathieu</creator><creator>Tezenas du Montcel, Sophie</creator><creator>Giunti, Paola</creator><creator>Labrum, Robyn</creator><creator>Dürr, Alexandra</creator><creator>Ribai, Pascale</creator><creator>Charles, Perrine</creator><creator>Linnemann, Christoph</creator><creator>Schöls, Ludger</creator><creator>Rakowicz, Maryla</creator><creator>Rola, Rafal</creator><creator>Zdzienicka, Elszbieta</creator><creator>Fancellu, Roberto</creator><creator>Mariotti, Caterina</creator><creator>Baliko, Lazlo</creator><creator>Melegh, Bela</creator><creator>Filla, Alessandro</creator><creator>Salvatore, Elena</creator><creator>van de Warrenburg, Bart P.C.</creator><creator>Szymanski, Sandra</creator><creator>Infante, Jon</creator><creator>Timmann, Dagmar</creator><creator>Boesch, Sylvia</creator><creator>Depondt, Chantal</creator><creator>Kang, Jun-Suk</creator><creator>Schulz, Jörg B.</creator><creator>Klopstock, Thomas</creator><creator>Lossnitzer, Nicole</creator><creator>Löwe, Bernd</creator><creator>Frick, Caroline</creator><creator>Rottländer, Daniela</creator><creator>Schlaepfer, Thomas E.</creator><creator>Klockgether, Thomas</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Depression comorbidity in spinocerebellar ataxia</title><author>Schmitz-Hübsch, Tanja ; Coudert, Mathieu ; Tezenas du Montcel, Sophie ; Giunti, Paola ; Labrum, Robyn ; Dürr, Alexandra ; Ribai, Pascale ; Charles, Perrine ; Linnemann, Christoph ; Schöls, Ludger ; Rakowicz, Maryla ; Rola, Rafal ; Zdzienicka, Elszbieta ; Fancellu, Roberto ; Mariotti, Caterina ; Baliko, Lazlo ; Melegh, Bela ; Filla, Alessandro ; Salvatore, Elena ; van de Warrenburg, Bart P.C. ; Szymanski, Sandra ; Infante, Jon ; Timmann, Dagmar ; Boesch, Sylvia ; Depondt, Chantal ; Kang, Jun-Suk ; Schulz, Jörg B. ; Klopstock, Thomas ; Lossnitzer, Nicole ; Löwe, Bernd ; Frick, Caroline ; Rottländer, Daniela ; Schlaepfer, Thomas E. ; Klockgether, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4638-249ebb17adfbef6071c71e20af96dd48322268540075e9418418f3e215c9d5ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>cerebellum</topic><topic>Comorbidity</topic><topic>depression</topic><topic>Depression - drug therapy</topic><topic>Depression - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>prevalence studies</topic><topic>spinocerebellar ataxia</topic><topic>Spinocerebellar Ataxias - epidemiology</topic><topic>Spinocerebellar Ataxias - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmitz-Hübsch, Tanja</creatorcontrib><creatorcontrib>Coudert, Mathieu</creatorcontrib><creatorcontrib>Tezenas du Montcel, Sophie</creatorcontrib><creatorcontrib>Giunti, Paola</creatorcontrib><creatorcontrib>Labrum, Robyn</creatorcontrib><creatorcontrib>Dürr, Alexandra</creatorcontrib><creatorcontrib>Ribai, Pascale</creatorcontrib><creatorcontrib>Charles, Perrine</creatorcontrib><creatorcontrib>Linnemann, Christoph</creatorcontrib><creatorcontrib>Schöls, Ludger</creatorcontrib><creatorcontrib>Rakowicz, Maryla</creatorcontrib><creatorcontrib>Rola, Rafal</creatorcontrib><creatorcontrib>Zdzienicka, Elszbieta</creatorcontrib><creatorcontrib>Fancellu, Roberto</creatorcontrib><creatorcontrib>Mariotti, Caterina</creatorcontrib><creatorcontrib>Baliko, Lazlo</creatorcontrib><creatorcontrib>Melegh, Bela</creatorcontrib><creatorcontrib>Filla, Alessandro</creatorcontrib><creatorcontrib>Salvatore, Elena</creatorcontrib><creatorcontrib>van de Warrenburg, Bart P.C.</creatorcontrib><creatorcontrib>Szymanski, Sandra</creatorcontrib><creatorcontrib>Infante, Jon</creatorcontrib><creatorcontrib>Timmann, Dagmar</creatorcontrib><creatorcontrib>Boesch, Sylvia</creatorcontrib><creatorcontrib>Depondt, Chantal</creatorcontrib><creatorcontrib>Kang, Jun-Suk</creatorcontrib><creatorcontrib>Schulz, Jörg B.</creatorcontrib><creatorcontrib>Klopstock, Thomas</creatorcontrib><creatorcontrib>Lossnitzer, Nicole</creatorcontrib><creatorcontrib>Löwe, Bernd</creatorcontrib><creatorcontrib>Frick, Caroline</creatorcontrib><creatorcontrib>Rottländer, Daniela</creatorcontrib><creatorcontrib>Schlaepfer, Thomas E.</creatorcontrib><creatorcontrib>Klockgether, Thomas</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmitz-Hübsch, Tanja</au><au>Coudert, Mathieu</au><au>Tezenas du Montcel, Sophie</au><au>Giunti, Paola</au><au>Labrum, Robyn</au><au>Dürr, Alexandra</au><au>Ribai, Pascale</au><au>Charles, Perrine</au><au>Linnemann, Christoph</au><au>Schöls, Ludger</au><au>Rakowicz, Maryla</au><au>Rola, Rafal</au><au>Zdzienicka, Elszbieta</au><au>Fancellu, Roberto</au><au>Mariotti, Caterina</au><au>Baliko, Lazlo</au><au>Melegh, Bela</au><au>Filla, Alessandro</au><au>Salvatore, Elena</au><au>van de Warrenburg, Bart P.C.</au><au>Szymanski, Sandra</au><au>Infante, Jon</au><au>Timmann, Dagmar</au><au>Boesch, Sylvia</au><au>Depondt, Chantal</au><au>Kang, Jun-Suk</au><au>Schulz, Jörg B.</au><au>Klopstock, Thomas</au><au>Lossnitzer, Nicole</au><au>Löwe, Bernd</au><au>Frick, Caroline</au><au>Rottländer, Daniela</au><au>Schlaepfer, Thomas E.</au><au>Klockgether, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression comorbidity in spinocerebellar ataxia</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. Disord</addtitle><date>2011-04</date><risdate>2011</risdate><volume>26</volume><issue>5</issue><spage>870</spage><epage>876</epage><pages>870-876</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>This is a description of the prevalence and profile of depressive symptoms in dominant spinocerebellar ataxia (SCA). Depressive symptoms were assessed in a convenience sample of 526 genetically confirmed and clinically affected patients (117 SCA1, 163 SCA2, 139 SCA3, and 107 SCA6) using the Patient Health Questionnaire (PHQ). In addition, depressive status according to the examiner and the use of antidepressants was recorded. Depression self‐assessment was compared with an interview‐based psychiatric assessment in a subset of 26 patients. Depression prevalence estimates were 17.1% according to the PHQ algorithm and 15.4% when assessed clinically. The sensitivity of clinical impression compared with PHQ classification was low (0.35), whereas diagnostic accuracy of PHQ compared with psychiatric interview in the subset was high. Antidepressants were used by 17.7% of patients and in >10% of patients without current clinically relevant depressive symptoms. Depression profile in SCA did not differ from a sample of patients with major depressive disorder except for the movement‐related item. Neither depression prevalence nor use of antidepressants differed between genetic subtypes, with only sleep disturbance more common in SCA3. In a multivariate analysis, ataxia severity and female sex independently predicted depressive status in SCA. The PHQ algorithmic classification is appropriate for use in SCA but should stimulate further psychiatric evaluation if depression is indicated. Despite a higher risk for depression with more severe disease, the relation of depressive symptoms to SCA neurodegeneration remains to be shown. © 2011 Movement Disorder Society</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21437988</pmid><doi>10.1002/mds.23698</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0885-3185 |
ispartof | Movement disorders, 2011-04, Vol.26 (5), p.870-876 |
issn | 0885-3185 1531-8257 |
language | eng |
recordid | cdi_proquest_miscellaneous_863768068 |
source | MEDLINE; Access via Wiley Online Library |
subjects | Aged Antidepressive Agents - therapeutic use cerebellum Comorbidity depression Depression - drug therapy Depression - epidemiology Female Humans Male Middle Aged Prevalence prevalence studies spinocerebellar ataxia Spinocerebellar Ataxias - epidemiology Spinocerebellar Ataxias - genetics |
title | Depression comorbidity in spinocerebellar ataxia |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T02%3A42%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Depression%20comorbidity%20in%20spinocerebellar%20ataxia&rft.jtitle=Movement%20disorders&rft.au=Schmitz-H%C3%BCbsch,%20Tanja&rft.date=2011-04&rft.volume=26&rft.issue=5&rft.spage=870&rft.epage=876&rft.pages=870-876&rft.issn=0885-3185&rft.eissn=1531-8257&rft_id=info:doi/10.1002/mds.23698&rft_dat=%3Cproquest_cross%3E863768068%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=863768068&rft_id=info:pmid/21437988&rfr_iscdi=true |