Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children
ABSTRACT There is no existing data on UL97 mutation in human cytomegalovirus (HCMV) isolates obtained from individuals who have never been exposed to ganciclovir (GCV). UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known...
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| Veröffentlicht in: | Microbiology and immunology 2011-05, Vol.55 (5), p.328-330 |
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| container_title | Microbiology and immunology |
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| creator | Tanaka, Kaori Hori, Tsukasa Yoto, Yuko Hatakeyama, Naoki Yamamoto, Masaki Suzuki, Nobuhiro Tsutsumi, Hiroyuki |
| description | ABSTRACT
There is no existing data on UL97 mutation in human cytomegalovirus (HCMV) isolates obtained from individuals who have never been exposed to ganciclovir (GCV). UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605 (D to E) was frequently identified (56/61: 91.8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries. |
| doi_str_mv | 10.1111/j.1348-0421.2011.00327.x |
| format | Article |
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There is no existing data on UL97 mutation in human cytomegalovirus (HCMV) isolates obtained from individuals who have never been exposed to ganciclovir (GCV). UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605 (D to E) was frequently identified (56/61: 91.8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/j.1348-0421.2011.00327.x</identifier><identifier>PMID: 21362026</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Antiviral Agents - therapeutic use ; Asian Continental Ancestry Group - genetics ; Child ; Codon ; cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus Infections - epidemiology ; Cytomegalovirus Infections - virology ; Drug Resistance, Viral ; ganciclovir ; Ganciclovir - therapeutic use ; Humans ; Immunocompetence ; Infant ; Molecular Epidemiology ; Mutation ; Phosphotransferases (Alcohol Group Acceptor) - genetics ; Polymorphism, Genetic ; UL97 polymorphism</subject><ispartof>Microbiology and immunology, 2011-05, Vol.55 (5), p.328-330</ispartof><rights>2011 The Societies and Blackwell Publishing Asia Pty Ltd</rights><rights>2011 The Societies and Blackwell Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4727-388f5b54591e4fd7212ab7f44bdfab31719b4320753ca78421740c7cd6ddafe33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1348-0421.2011.00327.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1348-0421.2011.00327.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21362026$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Kaori</creatorcontrib><creatorcontrib>Hori, Tsukasa</creatorcontrib><creatorcontrib>Yoto, Yuko</creatorcontrib><creatorcontrib>Hatakeyama, Naoki</creatorcontrib><creatorcontrib>Yamamoto, Masaki</creatorcontrib><creatorcontrib>Suzuki, Nobuhiro</creatorcontrib><creatorcontrib>Tsutsumi, Hiroyuki</creatorcontrib><title>Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
There is no existing data on UL97 mutation in human cytomegalovirus (HCMV) isolates obtained from individuals who have never been exposed to ganciclovir (GCV). UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605 (D to E) was frequently identified (56/61: 91.8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries.</description><subject>Antiviral Agents - therapeutic use</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Child</subject><subject>Codon</subject><subject>cytomegalovirus</subject><subject>Cytomegalovirus - genetics</subject><subject>Cytomegalovirus Infections - epidemiology</subject><subject>Cytomegalovirus Infections - virology</subject><subject>Drug Resistance, Viral</subject><subject>ganciclovir</subject><subject>Ganciclovir - therapeutic use</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>Infant</subject><subject>Molecular Epidemiology</subject><subject>Mutation</subject><subject>Phosphotransferases (Alcohol Group Acceptor) - genetics</subject><subject>Polymorphism, Genetic</subject><subject>UL97 polymorphism</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UctOwzAQtBAIyuMXkG-cEvyMU4kLglIeBS4gjpbjOMQldkKcQPv3JBS6l11pZla7MwBAjGI81PkyxpSlEWIExwRhHCNEiYhXO2CyBXbBBNGURzxB6AAchrBEiAiSsn1wQDBNCCLJBHS3vVMe6nVXO_OuqvrLtn2Ar4upgNcJ4jPY1NXa1W1T2uBgqQJUsLTvJWxa86Uq47WB1kPrXO9rXbvGdMZ38F41ypswYoXy3aDyOdSlrfLW-GOwV6gqmJO_fgReb2YvV7fR4nl-d3W5iDQTREQ0TQueccan2LAiFwQTlYmCsSwvVEaxwNOMUYIEp1qJdPhZMKSFzpM8V4Wh9AicbfY2bf3Zm9BJZ4M2VTWcVvdBpgkVieB8OjBP_5h95kwum9Y61a7lv1ED4WJD-LaVWW9xjOQYiFzK0Xc5-i7HQORvIHIlH-8eh2GQRxu5DZ1ZbeWq_ZCJoILLt6e5fJvzJ_ww55LTHycUjaQ</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Tanaka, Kaori</creator><creator>Hori, Tsukasa</creator><creator>Yoto, Yuko</creator><creator>Hatakeyama, Naoki</creator><creator>Yamamoto, Masaki</creator><creator>Suzuki, Nobuhiro</creator><creator>Tsutsumi, Hiroyuki</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201105</creationdate><title>Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children</title><author>Tanaka, Kaori ; Hori, Tsukasa ; Yoto, Yuko ; Hatakeyama, Naoki ; Yamamoto, Masaki ; Suzuki, Nobuhiro ; Tsutsumi, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4727-388f5b54591e4fd7212ab7f44bdfab31719b4320753ca78421740c7cd6ddafe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antiviral Agents - therapeutic use</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Child</topic><topic>Codon</topic><topic>cytomegalovirus</topic><topic>Cytomegalovirus - genetics</topic><topic>Cytomegalovirus Infections - epidemiology</topic><topic>Cytomegalovirus Infections - virology</topic><topic>Drug Resistance, Viral</topic><topic>ganciclovir</topic><topic>Ganciclovir - therapeutic use</topic><topic>Humans</topic><topic>Immunocompetence</topic><topic>Infant</topic><topic>Molecular Epidemiology</topic><topic>Mutation</topic><topic>Phosphotransferases (Alcohol Group Acceptor) - genetics</topic><topic>Polymorphism, Genetic</topic><topic>UL97 polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Kaori</creatorcontrib><creatorcontrib>Hori, Tsukasa</creatorcontrib><creatorcontrib>Yoto, Yuko</creatorcontrib><creatorcontrib>Hatakeyama, Naoki</creatorcontrib><creatorcontrib>Yamamoto, Masaki</creatorcontrib><creatorcontrib>Suzuki, Nobuhiro</creatorcontrib><creatorcontrib>Tsutsumi, Hiroyuki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Kaori</au><au>Hori, Tsukasa</au><au>Yoto, Yuko</au><au>Hatakeyama, Naoki</au><au>Yamamoto, Masaki</au><au>Suzuki, Nobuhiro</au><au>Tsutsumi, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2011-05</date><risdate>2011</risdate><volume>55</volume><issue>5</issue><spage>328</spage><epage>330</epage><pages>328-330</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>ABSTRACT
There is no existing data on UL97 mutation in human cytomegalovirus (HCMV) isolates obtained from individuals who have never been exposed to ganciclovir (GCV). UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605 (D to E) was frequently identified (56/61: 91.8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>21362026</pmid><doi>10.1111/j.1348-0421.2011.00327.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Microbiology and immunology, 2011-05, Vol.55 (5), p.328-330 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; Freely Accessible Japanese Titles; Alma/SFX Local Collection |
| subjects | Antiviral Agents - therapeutic use Asian Continental Ancestry Group - genetics Child Codon cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - virology Drug Resistance, Viral ganciclovir Ganciclovir - therapeutic use Humans Immunocompetence Infant Molecular Epidemiology Mutation Phosphotransferases (Alcohol Group Acceptor) - genetics Polymorphism, Genetic UL97 polymorphism |
| title | Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children |
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