Impact of intratumoral thymidylate synthase expression on prognosis after surgical resection for ampullary carcinoma
Background and Objectives This study evaluated possible prognostic value of expression level of intratumoral thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in patients with resected ampullary carcinoma. Methods Immunohistochemical stain...
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| Veröffentlicht in: | Journal of surgical oncology 2011-06, Vol.103 (7), p.663-668 |
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| container_title | Journal of surgical oncology |
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| creator | Kato, Yasushi Murakami, Yoshiaki Uemura, Kenichiro Sudo, Takeshi Hashimoto, Yasushi Hiyama, Eiso Sueda, Taijiro |
| description | Background and Objectives
This study evaluated possible prognostic value of expression level of intratumoral thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in patients with resected ampullary carcinoma.
Methods
Immunohistochemical staining evaluated intratumoral TS, DPD, and OPRT expression in 52 surgical specimens of patients with ampullary carcinoma. Relationships between clinicopathological factors including intratumoral TS, DPD, or OPRT expressions and survival was evaluated by univariate and multivariate analysis.
Results
High intratumoral DPD, OPRT, and TS expressions were found in 19 (37%), 30 (58%), and 23 (44%) of cases, respectively. Patients with high TS expression had more advanced‐stage disease than those with low TS expression. Univariate analysis revealed that gender, perineural invasion, lymph node status, UICC pT factor, UICC stage, OPRT expression, and TS expression correlated significantly (P |
| doi_str_mv | 10.1002/jso.21879 |
| format | Article |
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This study evaluated possible prognostic value of expression level of intratumoral thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in patients with resected ampullary carcinoma.
Methods
Immunohistochemical staining evaluated intratumoral TS, DPD, and OPRT expression in 52 surgical specimens of patients with ampullary carcinoma. Relationships between clinicopathological factors including intratumoral TS, DPD, or OPRT expressions and survival was evaluated by univariate and multivariate analysis.
Results
High intratumoral DPD, OPRT, and TS expressions were found in 19 (37%), 30 (58%), and 23 (44%) of cases, respectively. Patients with high TS expression had more advanced‐stage disease than those with low TS expression. Univariate analysis revealed that gender, perineural invasion, lymph node status, UICC pT factor, UICC stage, OPRT expression, and TS expression correlated significantly (P < 0.05) with disease‐specific survival. Only perineural invasion (P = 0.043) and TS expression (P = 0.019) were independent prognostic factors of disease‐specific survival by multivariate survival analysis. Five‐year disease‐specific survival rates of patients with high and low intratumoral TS expression were 47% and 91%, respectively.
Conclusions
Intratumoral TS expression level may be a potent predictor of prognosis after surgical resection for ampullary carcinoma. J. Surg. Oncol. 2011;103:663–668. © 2011 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.21879</identifier><identifier>PMID: 21360535</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Ampulla of Vater - metabolism ; Ampulla of Vater - pathology ; Ampulla of Vater - surgery ; ampullary carcinoma ; Carcinoma - metabolism ; Carcinoma - mortality ; Carcinoma - surgery ; Common Bile Duct Neoplasms - metabolism ; Common Bile Duct Neoplasms - mortality ; Common Bile Duct Neoplasms - surgery ; dihydropyrimidine dehydrogenase ; Dihydrouracil Dehydrogenase (NADP) - metabolism ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; orotate phosphoribosyltransferase ; Orotate Phosphoribosyltransferase - metabolism ; Prognosis ; prognostic factor ; Survival Rate ; thymidylate synthase ; Thymidylate Synthase - metabolism</subject><ispartof>Journal of surgical oncology, 2011-06, Vol.103 (7), p.663-668</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4289-9bf64d5f318f341eb44329f87c64f1d1315c154abd50d54c2bea9c722662fd323</citedby><cites>FETCH-LOGICAL-c4289-9bf64d5f318f341eb44329f87c64f1d1315c154abd50d54c2bea9c722662fd323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.21879$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.21879$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21360535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kato, Yasushi</creatorcontrib><creatorcontrib>Murakami, Yoshiaki</creatorcontrib><creatorcontrib>Uemura, Kenichiro</creatorcontrib><creatorcontrib>Sudo, Takeshi</creatorcontrib><creatorcontrib>Hashimoto, Yasushi</creatorcontrib><creatorcontrib>Hiyama, Eiso</creatorcontrib><creatorcontrib>Sueda, Taijiro</creatorcontrib><title>Impact of intratumoral thymidylate synthase expression on prognosis after surgical resection for ampullary carcinoma</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives
This study evaluated possible prognostic value of expression level of intratumoral thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in patients with resected ampullary carcinoma.
Methods
Immunohistochemical staining evaluated intratumoral TS, DPD, and OPRT expression in 52 surgical specimens of patients with ampullary carcinoma. Relationships between clinicopathological factors including intratumoral TS, DPD, or OPRT expressions and survival was evaluated by univariate and multivariate analysis.
Results
High intratumoral DPD, OPRT, and TS expressions were found in 19 (37%), 30 (58%), and 23 (44%) of cases, respectively. Patients with high TS expression had more advanced‐stage disease than those with low TS expression. Univariate analysis revealed that gender, perineural invasion, lymph node status, UICC pT factor, UICC stage, OPRT expression, and TS expression correlated significantly (P < 0.05) with disease‐specific survival. Only perineural invasion (P = 0.043) and TS expression (P = 0.019) were independent prognostic factors of disease‐specific survival by multivariate survival analysis. Five‐year disease‐specific survival rates of patients with high and low intratumoral TS expression were 47% and 91%, respectively.
Conclusions
Intratumoral TS expression level may be a potent predictor of prognosis after surgical resection for ampullary carcinoma. J. Surg. Oncol. 2011;103:663–668. © 2011 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ampulla of Vater - metabolism</subject><subject>Ampulla of Vater - pathology</subject><subject>Ampulla of Vater - surgery</subject><subject>ampullary carcinoma</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - surgery</subject><subject>Common Bile Duct Neoplasms - metabolism</subject><subject>Common Bile Duct Neoplasms - mortality</subject><subject>Common Bile Duct Neoplasms - surgery</subject><subject>dihydropyrimidine dehydrogenase</subject><subject>Dihydrouracil Dehydrogenase (NADP) - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>orotate phosphoribosyltransferase</subject><subject>Orotate Phosphoribosyltransferase - metabolism</subject><subject>Prognosis</subject><subject>prognostic factor</subject><subject>Survival Rate</subject><subject>thymidylate synthase</subject><subject>Thymidylate Synthase - metabolism</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PFTEYhRujkSu68A-Y7oyLgX53ulQiiCGwQIJx03Q6LRRnpkPbicy_t9cL7EyavIs-5-TkAeA9RgcYIXJ4l-MBwa1UL8AGIyUahVT7EmzqH2mYVGgPvMn5DiGklGCvwR7BVCBO-QaU03E2tsDoYZhKMmUZYzIDLLfrGPp1MMXBvE7l1mQH3cOcXM4hTrC-OcWbKeaQofHFJZiXdBNszVbG2bKlfEzQjPMyDCat0JpkwxRH8xa88mbI7t3j3QdXx19_HH1rzi5OTo8-nzWWkVY1qvOC9dxT3HrKsOsYo0T5VlrBPO4xxdxizkzXc9RzZknnjLKSECGI7ymh--DjrrdOvV9cLnoM2bq6ZnJxyboVVApJ1Jb8tCNtijkn5_WcwlhHa4z01rGujvU_x5X98Ni6dKPrn8knqRU43AF_wuDW_zfp75cXT5XNLhFycQ_PCZN-ayGp5Pr6_ERz-Ysd_6RYf6F_AeWlmAI</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Kato, Yasushi</creator><creator>Murakami, Yoshiaki</creator><creator>Uemura, Kenichiro</creator><creator>Sudo, Takeshi</creator><creator>Hashimoto, Yasushi</creator><creator>Hiyama, Eiso</creator><creator>Sueda, Taijiro</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>Impact of intratumoral thymidylate synthase expression on prognosis after surgical resection for ampullary carcinoma</title><author>Kato, Yasushi ; Murakami, Yoshiaki ; Uemura, Kenichiro ; Sudo, Takeshi ; Hashimoto, Yasushi ; Hiyama, Eiso ; Sueda, Taijiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4289-9bf64d5f318f341eb44329f87c64f1d1315c154abd50d54c2bea9c722662fd323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ampulla of Vater - metabolism</topic><topic>Ampulla of Vater - pathology</topic><topic>Ampulla of Vater - surgery</topic><topic>ampullary carcinoma</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - surgery</topic><topic>Common Bile Duct Neoplasms - metabolism</topic><topic>Common Bile Duct Neoplasms - mortality</topic><topic>Common Bile Duct Neoplasms - surgery</topic><topic>dihydropyrimidine dehydrogenase</topic><topic>Dihydrouracil Dehydrogenase (NADP) - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>orotate phosphoribosyltransferase</topic><topic>Orotate Phosphoribosyltransferase - metabolism</topic><topic>Prognosis</topic><topic>prognostic factor</topic><topic>Survival Rate</topic><topic>thymidylate synthase</topic><topic>Thymidylate Synthase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kato, Yasushi</creatorcontrib><creatorcontrib>Murakami, Yoshiaki</creatorcontrib><creatorcontrib>Uemura, Kenichiro</creatorcontrib><creatorcontrib>Sudo, Takeshi</creatorcontrib><creatorcontrib>Hashimoto, Yasushi</creatorcontrib><creatorcontrib>Hiyama, Eiso</creatorcontrib><creatorcontrib>Sueda, Taijiro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kato, Yasushi</au><au>Murakami, Yoshiaki</au><au>Uemura, Kenichiro</au><au>Sudo, Takeshi</au><au>Hashimoto, Yasushi</au><au>Hiyama, Eiso</au><au>Sueda, Taijiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of intratumoral thymidylate synthase expression on prognosis after surgical resection for ampullary carcinoma</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>103</volume><issue>7</issue><spage>663</spage><epage>668</epage><pages>663-668</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
This study evaluated possible prognostic value of expression level of intratumoral thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in patients with resected ampullary carcinoma.
Methods
Immunohistochemical staining evaluated intratumoral TS, DPD, and OPRT expression in 52 surgical specimens of patients with ampullary carcinoma. Relationships between clinicopathological factors including intratumoral TS, DPD, or OPRT expressions and survival was evaluated by univariate and multivariate analysis.
Results
High intratumoral DPD, OPRT, and TS expressions were found in 19 (37%), 30 (58%), and 23 (44%) of cases, respectively. Patients with high TS expression had more advanced‐stage disease than those with low TS expression. Univariate analysis revealed that gender, perineural invasion, lymph node status, UICC pT factor, UICC stage, OPRT expression, and TS expression correlated significantly (P < 0.05) with disease‐specific survival. Only perineural invasion (P = 0.043) and TS expression (P = 0.019) were independent prognostic factors of disease‐specific survival by multivariate survival analysis. Five‐year disease‐specific survival rates of patients with high and low intratumoral TS expression were 47% and 91%, respectively.
Conclusions
Intratumoral TS expression level may be a potent predictor of prognosis after surgical resection for ampullary carcinoma. J. Surg. Oncol. 2011;103:663–668. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21360535</pmid><doi>10.1002/jso.21879</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Ampulla of Vater - metabolism Ampulla of Vater - pathology Ampulla of Vater - surgery ampullary carcinoma Carcinoma - metabolism Carcinoma - mortality Carcinoma - surgery Common Bile Duct Neoplasms - metabolism Common Bile Duct Neoplasms - mortality Common Bile Duct Neoplasms - surgery dihydropyrimidine dehydrogenase Dihydrouracil Dehydrogenase (NADP) - metabolism Female Humans Male Middle Aged Multivariate Analysis Neoplasm Invasiveness orotate phosphoribosyltransferase Orotate Phosphoribosyltransferase - metabolism Prognosis prognostic factor Survival Rate thymidylate synthase Thymidylate Synthase - metabolism |
| title | Impact of intratumoral thymidylate synthase expression on prognosis after surgical resection for ampullary carcinoma |
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