Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music
Music is listened in all cultures. We hypothesize that willingness to produce and perceive sound and music is social communication that needs musical aptitude. Here, listening to music was surveyed using a web-based questionnaire and musical aptitude using the auditory structuring ability test (Karm...
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| Veröffentlicht in: | Journal of human genetics 2011-04, Vol.56 (4), p.324-329 |
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| creator | Ukkola-Vuoti, Liisa Oikkonen, Jaana Onkamo, Päivi Karma, Kai Raijas, Pirre Järvelä, Irma |
| description | Music is listened in all cultures. We hypothesize that willingness to produce and perceive sound and music is social communication that needs musical aptitude. Here, listening to music was surveyed using a web-based questionnaire and musical aptitude using the auditory structuring ability test (Karma Music test) and Carl Seashores tests for pitch and for time. Three highly polymorphic microsatellite markers (RS3, RS1 and AVR) of the arginine vasopressin receptor 1A (
AVPR1A
) gene, previously associated with social communication and attachment, were genotyped and analyzed in 31 Finnish families (
n
=437 members) using family-based association analysis. A positive association between the
AVPR1A
haplotype (RS1 and AVR) and active current listening to music (permuted
P
=0.0019) was observed. Other
AVPR1A
haplotype (RS3 and AVR) showed association with lifelong active listening to music (permuted
P
=0.0022). In addition to
AVPR1A
, two polymorphisms (5-HTTLPR and variable number of tandem repeat) of human serotonin transporter gene (
SLC6A4
), a candidate gene for many neuropsychiatric disorders and previously associated with emotional processing, were analyzed. No association between listening to music and the polymorphisms of
SLC6A4
were detected. The results suggest that willingness to listen to music is related to neurobiological pathways affecting social affiliation and communication. |
| doi_str_mv | 10.1038/jhg.2011.13 |
| format | Article |
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AVPR1A
) gene, previously associated with social communication and attachment, were genotyped and analyzed in 31 Finnish families (
n
=437 members) using family-based association analysis. A positive association between the
AVPR1A
haplotype (RS1 and AVR) and active current listening to music (permuted
P
=0.0019) was observed. Other
AVPR1A
haplotype (RS3 and AVR) showed association with lifelong active listening to music (permuted
P
=0.0022). In addition to
AVPR1A
, two polymorphisms (5-HTTLPR and variable number of tandem repeat) of human serotonin transporter gene (
SLC6A4
), a candidate gene for many neuropsychiatric disorders and previously associated with emotional processing, were analyzed. No association between listening to music and the polymorphisms of
SLC6A4
were detected. The results suggest that willingness to listen to music is related to neurobiological pathways affecting social affiliation and communication.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1038/jhg.2011.13</identifier><identifier>PMID: 21307861</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/728 ; 706/648/126/506 ; Ability tests ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aptitude - physiology ; Argipressin ; Argipressin receptors ; Association analysis ; Attention ; Biomedical and Life Sciences ; Biomedicine ; Child ; Communication ; Female ; Finland ; Frequency ; Gene Expression ; Gene Function ; Gene Therapy ; Genetic markers ; Genotype ; Haplotypes ; Haplotypes - genetics ; Human Genetics ; Humans ; Internet ; Listening ; Male ; Mental disorders ; Microsatellite Repeats - genetics ; Microsatellites ; Middle Aged ; Molecular Medicine ; Music ; original-article ; Pedigree ; Receptors, Vasopressin - genetics ; Serotonin ; Serotonin Plasma Membrane Transport Proteins - genetics ; Serotonin transporter ; Social Behavior ; Social interactions ; Surveys and Questionnaires ; Vasopressin</subject><ispartof>Journal of human genetics, 2011-04, Vol.56 (4), p.324-329</ispartof><rights>The Japan Society of Human Genetics 2011</rights><rights>The Japan Society of Human Genetics 2011.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-c22ba2f159af90e08464d2a72a69d71862b4b6de506722fff18ff1d4236339fe3</citedby><cites>FETCH-LOGICAL-c447t-c22ba2f159af90e08464d2a72a69d71862b4b6de506722fff18ff1d4236339fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhg.2011.13$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhg.2011.13$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21307861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ukkola-Vuoti, Liisa</creatorcontrib><creatorcontrib>Oikkonen, Jaana</creatorcontrib><creatorcontrib>Onkamo, Päivi</creatorcontrib><creatorcontrib>Karma, Kai</creatorcontrib><creatorcontrib>Raijas, Pirre</creatorcontrib><creatorcontrib>Järvelä, Irma</creatorcontrib><title>Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>Music is listened in all cultures. We hypothesize that willingness to produce and perceive sound and music is social communication that needs musical aptitude. Here, listening to music was surveyed using a web-based questionnaire and musical aptitude using the auditory structuring ability test (Karma Music test) and Carl Seashores tests for pitch and for time. Three highly polymorphic microsatellite markers (RS3, RS1 and AVR) of the arginine vasopressin receptor 1A (
AVPR1A
) gene, previously associated with social communication and attachment, were genotyped and analyzed in 31 Finnish families (
n
=437 members) using family-based association analysis. A positive association between the
AVPR1A
haplotype (RS1 and AVR) and active current listening to music (permuted
P
=0.0019) was observed. Other
AVPR1A
haplotype (RS3 and AVR) showed association with lifelong active listening to music (permuted
P
=0.0022). In addition to
AVPR1A
, two polymorphisms (5-HTTLPR and variable number of tandem repeat) of human serotonin transporter gene (
SLC6A4
), a candidate gene for many neuropsychiatric disorders and previously associated with emotional processing, were analyzed. No association between listening to music and the polymorphisms of
SLC6A4
were detected. The results suggest that willingness to listen to music is related to neurobiological pathways affecting social affiliation and communication.</description><subject>631/208/728</subject><subject>706/648/126/506</subject><subject>Ability tests</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aptitude - physiology</subject><subject>Argipressin</subject><subject>Argipressin receptors</subject><subject>Association analysis</subject><subject>Attention</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Child</subject><subject>Communication</subject><subject>Female</subject><subject>Finland</subject><subject>Frequency</subject><subject>Gene Expression</subject><subject>Gene Function</subject><subject>Gene Therapy</subject><subject>Genetic markers</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internet</subject><subject>Listening</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Microsatellite Repeats - genetics</subject><subject>Microsatellites</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Music</subject><subject>original-article</subject><subject>Pedigree</subject><subject>Receptors, Vasopressin - genetics</subject><subject>Serotonin</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Serotonin transporter</subject><subject>Social Behavior</subject><subject>Social interactions</subject><subject>Surveys and Questionnaires</subject><subject>Vasopressin</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kd9rFDEQx0Ox2Hr1yXcJ-GBF90wm2eze41L8UShYpJW-hdzu5C7H3mZNskr_--a82oIUH4YZmM98h5kvIa84m3Mm6o-b9WoOjPM5FwfkmEtRFiDg5tmfWhYlV_yIvIhxwxgTUMFzcgRcsKpW_JjoJkbfOpOcH6i3NK2RmrBygxuQ_jLRjwFjdAMN2OKYfKC8oafNj8vvvHlH12bsfbodMdLfLq1p72LCPLqiydPtFF17Qg6t6SO-vM8zcv3509XZ1-Li25fzs-aiaKWsUtECLA1YXi6MXTBktVSyA1OBUYuu4rWCpVyqDkumKgBrLa9zdBKEEmJhUczI273uGPzPCWPSWxdb7HszoJ-irpWo8mh-2Iyc_pfcPY0JpqDO6Jt_0I2fwpDv0CABGJQV7ATf76k2-BgDWj0GtzXhVnOmdw7p7JDeOaS5yPTre81pucXugf1rSQY-7IGYW8MKw-PSp_TuAKyDmL8</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Ukkola-Vuoti, Liisa</creator><creator>Oikkonen, Jaana</creator><creator>Onkamo, Päivi</creator><creator>Karma, Kai</creator><creator>Raijas, Pirre</creator><creator>Järvelä, Irma</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110401</creationdate><title>Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music</title><author>Ukkola-Vuoti, Liisa ; Oikkonen, Jaana ; Onkamo, Päivi ; Karma, Kai ; Raijas, Pirre ; Järvelä, Irma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-c22ba2f159af90e08464d2a72a69d71862b4b6de506722fff18ff1d4236339fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/728</topic><topic>706/648/126/506</topic><topic>Ability tests</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aptitude - physiology</topic><topic>Argipressin</topic><topic>Argipressin receptors</topic><topic>Association analysis</topic><topic>Attention</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Child</topic><topic>Communication</topic><topic>Female</topic><topic>Finland</topic><topic>Frequency</topic><topic>Gene Expression</topic><topic>Gene Function</topic><topic>Gene Therapy</topic><topic>Genetic markers</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Haplotypes - genetics</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internet</topic><topic>Listening</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Microsatellite Repeats - genetics</topic><topic>Microsatellites</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Music</topic><topic>original-article</topic><topic>Pedigree</topic><topic>Receptors, Vasopressin - genetics</topic><topic>Serotonin</topic><topic>Serotonin Plasma Membrane Transport Proteins - 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Academic</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ukkola-Vuoti, Liisa</au><au>Oikkonen, Jaana</au><au>Onkamo, Päivi</au><au>Karma, Kai</au><au>Raijas, Pirre</au><au>Järvelä, Irma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music</atitle><jtitle>Journal of human genetics</jtitle><stitle>J Hum Genet</stitle><addtitle>J Hum Genet</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>56</volume><issue>4</issue><spage>324</spage><epage>329</epage><pages>324-329</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Music is listened in all cultures. We hypothesize that willingness to produce and perceive sound and music is social communication that needs musical aptitude. Here, listening to music was surveyed using a web-based questionnaire and musical aptitude using the auditory structuring ability test (Karma Music test) and Carl Seashores tests for pitch and for time. Three highly polymorphic microsatellite markers (RS3, RS1 and AVR) of the arginine vasopressin receptor 1A (
AVPR1A
) gene, previously associated with social communication and attachment, were genotyped and analyzed in 31 Finnish families (
n
=437 members) using family-based association analysis. A positive association between the
AVPR1A
haplotype (RS1 and AVR) and active current listening to music (permuted
P
=0.0019) was observed. Other
AVPR1A
haplotype (RS3 and AVR) showed association with lifelong active listening to music (permuted
P
=0.0022). In addition to
AVPR1A
, two polymorphisms (5-HTTLPR and variable number of tandem repeat) of human serotonin transporter gene (
SLC6A4
), a candidate gene for many neuropsychiatric disorders and previously associated with emotional processing, were analyzed. No association between listening to music and the polymorphisms of
SLC6A4
were detected. The results suggest that willingness to listen to music is related to neurobiological pathways affecting social affiliation and communication.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21307861</pmid><doi>10.1038/jhg.2011.13</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 631/208/728 706/648/126/506 Ability tests Adolescent Adult Aged Aged, 80 and over Aptitude - physiology Argipressin Argipressin receptors Association analysis Attention Biomedical and Life Sciences Biomedicine Child Communication Female Finland Frequency Gene Expression Gene Function Gene Therapy Genetic markers Genotype Haplotypes Haplotypes - genetics Human Genetics Humans Internet Listening Male Mental disorders Microsatellite Repeats - genetics Microsatellites Middle Aged Molecular Medicine Music original-article Pedigree Receptors, Vasopressin - genetics Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Serotonin transporter Social Behavior Social interactions Surveys and Questionnaires Vasopressin |
| title | Association of the arginine vasopressin receptor 1A (AVPR1A) haplotypes with listening to music |
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