Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue
The aim of this study was to analyze the immunohistochemical expression of galectins-1, -3, -4, and -7 in 65 cases of squamous cell carcinoma of the tongue and to correlate this expression with clinical (disease outcome, metastasis, and clinical stage) and morphological parameters (histological grad...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2011-04, Vol.207 (4), p.236-240 |
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| creator | Alves, Pollianna M. Godoy, Gustavo P. Gomes, Daliana Q. Medeiros, Ana Miryam C. de Souza, Lélia B. da Silveira, Ericka J.D. Vasconcelos, Marcelo G. Queiroz, Lélia M.G. |
| description | The aim of this study was to analyze the immunohistochemical expression of galectins-1, -3, -4, and -7 in 65 cases of squamous cell carcinoma of the tongue and to correlate this expression with clinical (disease outcome, metastasis, and clinical stage) and morphological parameters (histological grade of malignancy). Clinical data were obtained from the patient records. The histological grading system of malignancy proposed by Bryne (1998)
[9] was used for the analysis of morphological parameters. The results were analyzed statistically by
χ
2 test (
p
<
0.05). Galectin-1 expression was observed in 87.7% of cases and was significantly correlated with metastasis (
p
=
0.033) and clinical stage (
p
=
0.016). Immunoexpression of galectin-3 was observed in 87.7% of cases and was correlated with the presence of metastasis (
p
=
0.033) and histological grade of malignancy (
p
=
0.031). Galectin-4 showed no significant correlation with any of the parameters studied. Expression of galectin-7 was observed in 73.8% of cases and was significantly correlated with the histological grade of malignancy (
p
=
0.005). In conclusion, the intense immunoexpression of galectins-1, -3, and -7 suggests the participation of these proteins in oral carcinogenesis and their use as markers of biological behavior and tumor progression in squamous cell carcinoma of the tongue. |
| doi_str_mv | 10.1016/j.prp.2011.02.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_863433501</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0344033811000306</els_id><sourcerecordid>863433501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-69d287874a8b2ba5a0f63e174cfcbdb0ab60838f2ea0be02bfcd3d9d6c463c8a3</originalsourceid><addsrcrecordid>eNp9kEFr3DAQhUVJ6W7S_oBcgm651M7I0spaeipLmxQCPTQ9C1kabbWsZUeyA_33kdkkxxwGwei9x5uPkEsGNQMmbw71mMa6AcZqaGoA8YGsmWSqAsnZGVkDF6ICztWKnOd8AIAWBPtEVg3j21aAWhP_J-xj8MGaaJEOnu7NEe0UYq7YV1rxMoKa6GjV0hDp9A_pmIZ9wpzDEBdDfpxNP8yZWjweqTXJhjj0Zvla1NMQ9zN-Jh-9OWb88vJekL8_fzzs7qr737e_dt_vKyuYmiq5dY1qVSuM6prObAx4yZG1wnrbuQ5MJ0Fx5Rs00CE0nbeOu62TVkhuleEX5PqUW0o-zpgn3Ye8FDMRS0etJBecb4AVJTspbRpyTuj1mEJv0n_NQC909aFsRr3Q1dDoQrd4rl7S565H9-Z4xVkE304CLDc-BUw624CFrAupUNVuCO_EPwPy-Inl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>863433501</pqid></control><display><type>article</type><title>Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Alves, Pollianna M. ; Godoy, Gustavo P. ; Gomes, Daliana Q. ; Medeiros, Ana Miryam C. ; de Souza, Lélia B. ; da Silveira, Ericka J.D. ; Vasconcelos, Marcelo G. ; Queiroz, Lélia M.G.</creator><creatorcontrib>Alves, Pollianna M. ; Godoy, Gustavo P. ; Gomes, Daliana Q. ; Medeiros, Ana Miryam C. ; de Souza, Lélia B. ; da Silveira, Ericka J.D. ; Vasconcelos, Marcelo G. ; Queiroz, Lélia M.G.</creatorcontrib><description>The aim of this study was to analyze the immunohistochemical expression of galectins-1, -3, -4, and -7 in 65 cases of squamous cell carcinoma of the tongue and to correlate this expression with clinical (disease outcome, metastasis, and clinical stage) and morphological parameters (histological grade of malignancy). Clinical data were obtained from the patient records. The histological grading system of malignancy proposed by Bryne (1998)
[9] was used for the analysis of morphological parameters. The results were analyzed statistically by
χ
2 test (
p
<
0.05). Galectin-1 expression was observed in 87.7% of cases and was significantly correlated with metastasis (
p
=
0.033) and clinical stage (
p
=
0.016). Immunoexpression of galectin-3 was observed in 87.7% of cases and was correlated with the presence of metastasis (
p
=
0.033) and histological grade of malignancy (
p
=
0.031). Galectin-4 showed no significant correlation with any of the parameters studied. Expression of galectin-7 was observed in 73.8% of cases and was significantly correlated with the histological grade of malignancy (
p
=
0.005). In conclusion, the intense immunoexpression of galectins-1, -3, and -7 suggests the participation of these proteins in oral carcinogenesis and their use as markers of biological behavior and tumor progression in squamous cell carcinoma of the tongue.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2011.02.004</identifier><identifier>PMID: 21397408</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Antibodies, Monoclonal ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secondary ; Female ; Galectin 1 - metabolism ; Galectin 3 - metabolism ; Galectin 4 - metabolism ; Galectins ; Galectins - metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Staging - methods ; Oral carcinogenesis ; Prognosis ; Squamous cell carcinoma of the tongue ; Tongue - metabolism ; Tongue - pathology ; Tongue Neoplasms - metabolism ; Tongue Neoplasms - pathology</subject><ispartof>Pathology, research and practice, 2011-04, Vol.207 (4), p.236-240</ispartof><rights>2011 Elsevier GmbH</rights><rights>Copyright © 2011 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-69d287874a8b2ba5a0f63e174cfcbdb0ab60838f2ea0be02bfcd3d9d6c463c8a3</citedby><cites>FETCH-LOGICAL-c418t-69d287874a8b2ba5a0f63e174cfcbdb0ab60838f2ea0be02bfcd3d9d6c463c8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prp.2011.02.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21397408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alves, Pollianna M.</creatorcontrib><creatorcontrib>Godoy, Gustavo P.</creatorcontrib><creatorcontrib>Gomes, Daliana Q.</creatorcontrib><creatorcontrib>Medeiros, Ana Miryam C.</creatorcontrib><creatorcontrib>de Souza, Lélia B.</creatorcontrib><creatorcontrib>da Silveira, Ericka J.D.</creatorcontrib><creatorcontrib>Vasconcelos, Marcelo G.</creatorcontrib><creatorcontrib>Queiroz, Lélia M.G.</creatorcontrib><title>Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>The aim of this study was to analyze the immunohistochemical expression of galectins-1, -3, -4, and -7 in 65 cases of squamous cell carcinoma of the tongue and to correlate this expression with clinical (disease outcome, metastasis, and clinical stage) and morphological parameters (histological grade of malignancy). Clinical data were obtained from the patient records. The histological grading system of malignancy proposed by Bryne (1998)
[9] was used for the analysis of morphological parameters. The results were analyzed statistically by
χ
2 test (
p
<
0.05). Galectin-1 expression was observed in 87.7% of cases and was significantly correlated with metastasis (
p
=
0.033) and clinical stage (
p
=
0.016). Immunoexpression of galectin-3 was observed in 87.7% of cases and was correlated with the presence of metastasis (
p
=
0.033) and histological grade of malignancy (
p
=
0.031). Galectin-4 showed no significant correlation with any of the parameters studied. Expression of galectin-7 was observed in 73.8% of cases and was significantly correlated with the histological grade of malignancy (
p
=
0.005). In conclusion, the intense immunoexpression of galectins-1, -3, and -7 suggests the participation of these proteins in oral carcinogenesis and their use as markers of biological behavior and tumor progression in squamous cell carcinoma of the tongue.</description><subject>Antibodies, Monoclonal</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Female</subject><subject>Galectin 1 - metabolism</subject><subject>Galectin 3 - metabolism</subject><subject>Galectin 4 - metabolism</subject><subject>Galectins</subject><subject>Galectins - metabolism</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging - methods</subject><subject>Oral carcinogenesis</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma of the tongue</subject><subject>Tongue - metabolism</subject><subject>Tongue - pathology</subject><subject>Tongue Neoplasms - metabolism</subject><subject>Tongue Neoplasms - pathology</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFr3DAQhUVJ6W7S_oBcgm651M7I0spaeipLmxQCPTQ9C1kabbWsZUeyA_33kdkkxxwGwei9x5uPkEsGNQMmbw71mMa6AcZqaGoA8YGsmWSqAsnZGVkDF6ICztWKnOd8AIAWBPtEVg3j21aAWhP_J-xj8MGaaJEOnu7NEe0UYq7YV1rxMoKa6GjV0hDp9A_pmIZ9wpzDEBdDfpxNP8yZWjweqTXJhjj0Zvla1NMQ9zN-Jh-9OWb88vJekL8_fzzs7qr737e_dt_vKyuYmiq5dY1qVSuM6prObAx4yZG1wnrbuQ5MJ0Fx5Rs00CE0nbeOu62TVkhuleEX5PqUW0o-zpgn3Ye8FDMRS0etJBecb4AVJTspbRpyTuj1mEJv0n_NQC909aFsRr3Q1dDoQrd4rl7S565H9-Z4xVkE304CLDc-BUw624CFrAupUNVuCO_EPwPy-Inl</recordid><startdate>20110415</startdate><enddate>20110415</enddate><creator>Alves, Pollianna M.</creator><creator>Godoy, Gustavo P.</creator><creator>Gomes, Daliana Q.</creator><creator>Medeiros, Ana Miryam C.</creator><creator>de Souza, Lélia B.</creator><creator>da Silveira, Ericka J.D.</creator><creator>Vasconcelos, Marcelo G.</creator><creator>Queiroz, Lélia M.G.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110415</creationdate><title>Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue</title><author>Alves, Pollianna M. ; Godoy, Gustavo P. ; Gomes, Daliana Q. ; Medeiros, Ana Miryam C. ; de Souza, Lélia B. ; da Silveira, Ericka J.D. ; Vasconcelos, Marcelo G. ; Queiroz, Lélia M.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-69d287874a8b2ba5a0f63e174cfcbdb0ab60838f2ea0be02bfcd3d9d6c463c8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antibodies, Monoclonal</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Female</topic><topic>Galectin 1 - metabolism</topic><topic>Galectin 3 - metabolism</topic><topic>Galectin 4 - metabolism</topic><topic>Galectins</topic><topic>Galectins - metabolism</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging - methods</topic><topic>Oral carcinogenesis</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma of the tongue</topic><topic>Tongue - metabolism</topic><topic>Tongue - pathology</topic><topic>Tongue Neoplasms - metabolism</topic><topic>Tongue Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alves, Pollianna M.</creatorcontrib><creatorcontrib>Godoy, Gustavo P.</creatorcontrib><creatorcontrib>Gomes, Daliana Q.</creatorcontrib><creatorcontrib>Medeiros, Ana Miryam C.</creatorcontrib><creatorcontrib>de Souza, Lélia B.</creatorcontrib><creatorcontrib>da Silveira, Ericka J.D.</creatorcontrib><creatorcontrib>Vasconcelos, Marcelo G.</creatorcontrib><creatorcontrib>Queiroz, Lélia M.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alves, Pollianna M.</au><au>Godoy, Gustavo P.</au><au>Gomes, Daliana Q.</au><au>Medeiros, Ana Miryam C.</au><au>de Souza, Lélia B.</au><au>da Silveira, Ericka J.D.</au><au>Vasconcelos, Marcelo G.</au><au>Queiroz, Lélia M.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2011-04-15</date><risdate>2011</risdate><volume>207</volume><issue>4</issue><spage>236</spage><epage>240</epage><pages>236-240</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>The aim of this study was to analyze the immunohistochemical expression of galectins-1, -3, -4, and -7 in 65 cases of squamous cell carcinoma of the tongue and to correlate this expression with clinical (disease outcome, metastasis, and clinical stage) and morphological parameters (histological grade of malignancy). Clinical data were obtained from the patient records. The histological grading system of malignancy proposed by Bryne (1998)
[9] was used for the analysis of morphological parameters. The results were analyzed statistically by
χ
2 test (
p
<
0.05). Galectin-1 expression was observed in 87.7% of cases and was significantly correlated with metastasis (
p
=
0.033) and clinical stage (
p
=
0.016). Immunoexpression of galectin-3 was observed in 87.7% of cases and was correlated with the presence of metastasis (
p
=
0.033) and histological grade of malignancy (
p
=
0.031). Galectin-4 showed no significant correlation with any of the parameters studied. Expression of galectin-7 was observed in 73.8% of cases and was significantly correlated with the histological grade of malignancy (
p
=
0.005). In conclusion, the intense immunoexpression of galectins-1, -3, and -7 suggests the participation of these proteins in oral carcinogenesis and their use as markers of biological behavior and tumor progression in squamous cell carcinoma of the tongue.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>21397408</pmid><doi>10.1016/j.prp.2011.02.004</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-0338 |
| ispartof | Pathology, research and practice, 2011-04, Vol.207 (4), p.236-240 |
| issn | 0344-0338 1618-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_863433501 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antibodies, Monoclonal Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secondary Female Galectin 1 - metabolism Galectin 3 - metabolism Galectin 4 - metabolism Galectins Galectins - metabolism Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Male Middle Aged Neoplasm Staging - methods Oral carcinogenesis Prognosis Squamous cell carcinoma of the tongue Tongue - metabolism Tongue - pathology Tongue Neoplasms - metabolism Tongue Neoplasms - pathology |
| title | Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue |
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