Cyclin-dependent kinase 5 phosphorylates mammalian HMGB1 protein only if acetylated

High mobility group box 1 (HMGB1) protein is the most abundant chromatin-associated non-histone protein expressed in all nucleated eukaryotic cells. We examined the phosphorylation of mammalian HMGB1 by testing the ability of the cyclin-dependent kinase 5 (Cdk5) to use as substrates native protein,...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2011-05, Vol.149 (5), p.563-568
Hauptverfasser:	Ugrinova, Iva, Pashev, Iliya G, Pasheva, Evdokia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cyclin-Dependent Kinase 5 - chemistry Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism DNA - chemistry DNA - metabolism HMGB1 Protein - chemistry HMGB1 Protein - genetics HMGB1 Protein - metabolism Nucleic Acid Conformation Phosphorylation Protein Conformation Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism
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